Limits...
Drug delivery systems: Advanced technologies potentially applicable in personalized treatments.

Coelho JF, Ferreira PC, Alves P, Cordeiro R, Fonseca AC, Góis JR, Gil MH - EPMA J (2010)

Bottom Line: Advanced drug delivery systems (DDS) present indubitable benefits for drug administration.The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers.In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, University of Coimbra, 3030-290 Coimbra, Portugal.

ABSTRACT
Advanced drug delivery systems (DDS) present indubitable benefits for drug administration. Over the past three decades, new approaches have been suggested for the development of novel carriers for drug delivery. In this review, we describe general concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes). This review is composed of two parts. The first part provides an overview on currently available drug delivery technologies including a brief history on the development of these systems and some of the research strategies applied. The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers. Their synthesis using controlled-living radical polymerization strategy is described. In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

No MeSH data available.


Related in: MedlinePlus

Structure of poly(ε-caprolactone)
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3405312&req=5

Fig18: Structure of poly(ε-caprolactone)

Mentions: PCL (Fig. 18) is a semicrystalline polymer with low melting point (Tm = 55–60°C) and glass transition temperature (Tg = −60°C). It possesses a low degradation rate, reason why it has been mainly used for preparation of long-term drug delivery devices [25]. PCL is highly permeable to small drug molecules. Another important feature is related to the non-generation of acidic by-products when it is degraded (contrarily to what happens with PLA and PLGA). Additionally, PCL offers the possibility of being easily blended with other polymers [81].Fig. 18


Drug delivery systems: Advanced technologies potentially applicable in personalized treatments.

Coelho JF, Ferreira PC, Alves P, Cordeiro R, Fonseca AC, Góis JR, Gil MH - EPMA J (2010)

Structure of poly(ε-caprolactone)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3405312&req=5

Fig18: Structure of poly(ε-caprolactone)
Mentions: PCL (Fig. 18) is a semicrystalline polymer with low melting point (Tm = 55–60°C) and glass transition temperature (Tg = −60°C). It possesses a low degradation rate, reason why it has been mainly used for preparation of long-term drug delivery devices [25]. PCL is highly permeable to small drug molecules. Another important feature is related to the non-generation of acidic by-products when it is degraded (contrarily to what happens with PLA and PLGA). Additionally, PCL offers the possibility of being easily blended with other polymers [81].Fig. 18

Bottom Line: Advanced drug delivery systems (DDS) present indubitable benefits for drug administration.The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers.In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, University of Coimbra, 3030-290 Coimbra, Portugal.

ABSTRACT
Advanced drug delivery systems (DDS) present indubitable benefits for drug administration. Over the past three decades, new approaches have been suggested for the development of novel carriers for drug delivery. In this review, we describe general concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes). This review is composed of two parts. The first part provides an overview on currently available drug delivery technologies including a brief history on the development of these systems and some of the research strategies applied. The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers. Their synthesis using controlled-living radical polymerization strategy is described. In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

No MeSH data available.


Related in: MedlinePlus