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Drug delivery systems: Advanced technologies potentially applicable in personalized treatments.

Coelho JF, Ferreira PC, Alves P, Cordeiro R, Fonseca AC, Góis JR, Gil MH - EPMA J (2010)

Bottom Line: Advanced drug delivery systems (DDS) present indubitable benefits for drug administration.The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers.In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, University of Coimbra, 3030-290 Coimbra, Portugal.

ABSTRACT
Advanced drug delivery systems (DDS) present indubitable benefits for drug administration. Over the past three decades, new approaches have been suggested for the development of novel carriers for drug delivery. In this review, we describe general concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes). This review is composed of two parts. The first part provides an overview on currently available drug delivery technologies including a brief history on the development of these systems and some of the research strategies applied. The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers. Their synthesis using controlled-living radical polymerization strategy is described. In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

No MeSH data available.


Related in: MedlinePlus

Schematic representation of the interaction of chitosan with sodium tripolyphospate giving micro/nanoparticles
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Fig12: Schematic representation of the interaction of chitosan with sodium tripolyphospate giving micro/nanoparticles

Mentions: Chitosan micro/nanoparticles are a widely used drug delivery devices. Chitosan particles based on ionotropic gelation method (Fig. 12) between sodium tripolyphospate and chitosan were tested as drug carriers for proteins, using bovine serum albumin (BSA) as model compound [49, 50]. The same kind of particles was also investigated as drug carriers for ophthalmologic applications and the obtained results showed that the chitosan nanoparticles are well tolerated by the ocular surface tissues [51, 52]. This method of preparation is very attractive, since it does not require severe reaction conditions, thus maintaining the integrity of the drug [49].Fig. 12


Drug delivery systems: Advanced technologies potentially applicable in personalized treatments.

Coelho JF, Ferreira PC, Alves P, Cordeiro R, Fonseca AC, Góis JR, Gil MH - EPMA J (2010)

Schematic representation of the interaction of chitosan with sodium tripolyphospate giving micro/nanoparticles
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3405312&req=5

Fig12: Schematic representation of the interaction of chitosan with sodium tripolyphospate giving micro/nanoparticles
Mentions: Chitosan micro/nanoparticles are a widely used drug delivery devices. Chitosan particles based on ionotropic gelation method (Fig. 12) between sodium tripolyphospate and chitosan were tested as drug carriers for proteins, using bovine serum albumin (BSA) as model compound [49, 50]. The same kind of particles was also investigated as drug carriers for ophthalmologic applications and the obtained results showed that the chitosan nanoparticles are well tolerated by the ocular surface tissues [51, 52]. This method of preparation is very attractive, since it does not require severe reaction conditions, thus maintaining the integrity of the drug [49].Fig. 12

Bottom Line: Advanced drug delivery systems (DDS) present indubitable benefits for drug administration.The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers.In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical Engineering, University of Coimbra, 3030-290 Coimbra, Portugal.

ABSTRACT
Advanced drug delivery systems (DDS) present indubitable benefits for drug administration. Over the past three decades, new approaches have been suggested for the development of novel carriers for drug delivery. In this review, we describe general concepts and emerging research in this field based on multidisciplinary approaches aimed at creating personalized treatment for a broad range of highly prevalent diseases (e.g., cancer and diabetes). This review is composed of two parts. The first part provides an overview on currently available drug delivery technologies including a brief history on the development of these systems and some of the research strategies applied. The second part provides information about the most advanced drug delivery devices using stimuli-responsive polymers. Their synthesis using controlled-living radical polymerization strategy is described. In a near future it is predictable the appearance of new effective tailor-made DDS, resulting from knowledge of different interdisciplinary sciences, in a perspective of creating personalized medical solutions.

No MeSH data available.


Related in: MedlinePlus