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Complex organochlorine pesticide mixtures as determinant factor for breast cancer risk: a population-based case-control study in the Canary Islands (Spain).

Boada LD, Zumbado M, Henríquez-Hernández LA, Almeida-González M, Alvarez-León EE, Serra-Majem L, Luzardo OP - Environ Health (2012)

Bottom Line: Exposure to organochlorine pesticides has been linked to an increased incidence of the disease, although not all data have been consistent.Most published studies evaluated the exposure to organochlorines individually, ignoring the potential effects exerted by the mixtures of chemicals.The most prevalent mixture of organochlorines among healthy women was the combination of lindane and endrin, and this mixture was not detected in any affected women.

View Article: PubMed Central - HTML - PubMed

Affiliation: Dpt of Clinical Sciences, Universidad de Las Palmas de Gran Canaria and Instituto Canario de Investigación del Cáncer-ICIC, P.O. Box 550, Las Palmas de Gran Canaria 35080, Spain. ldominguez@dcc.ulpgc.es

ABSTRACT

Background: All the relevant risk factors contributing to breast cancer etiology are not fully known. Exposure to organochlorine pesticides has been linked to an increased incidence of the disease, although not all data have been consistent. Most published studies evaluated the exposure to organochlorines individually, ignoring the potential effects exerted by the mixtures of chemicals.

Methods: This population-based study was designed to evaluate the profile of mixtures of organochlorines detected in 103 healthy women and 121 women diagnosed with breast cancer from Gran Canaria Island, and the relation between the exposure to these compounds and breast cancer risk.

Results: The most prevalent mixture of organochlorines among healthy women was the combination of lindane and endrin, and this mixture was not detected in any affected women. Breast cancer patients presented more frequently a combination of aldrin, dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD), and this mixture was not found in any healthy woman. After adjusting for covariables, the risk of breast cancer was moderately associated with DDD (OR = 1.008, confidence interval 95% 1.001-1.015, p = 0.024).

Conclusions: This study indicates that healthy women show a very different profile of organochlorine pesticide mixtures than breast cancer patients, suggesting that organochlorine pesticide mixtures could play a relevant role in breast cancer risk.

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Frequency of detection of organochlorine pesticides among breast cancer patients and healthy women.
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Figure 2: Frequency of detection of organochlorine pesticides among breast cancer patients and healthy women.

Mentions: As shown in Table 2, DDE (the main DDT-metabolite) was detected in most samples from healthy women and BC patients (89 and 97%, respectively). The other DDT-metabolite, DDD, was also found in a high number of serum samples (72%) from women suffering BC, but it was detected in a small number of healthy subjects (6%) (p < 0.001). Interestingly, the main component of technical DDT (p,p´-DDT), used in commercial formulations of DDT and banned in Spain in last 1970’s, was present in more than 70% of the samples from both groups of women. With respect to non-DDT-derivatives, we observed discrepant results. Thus, despite the fact that the presence of residues of lindane and dieldrin was similar in both groups of women (more than 20% in both cases), the percentage of samples showing detectable levels of aldrin was clearly higher in BC patients than in healthy women (74 vs. 38%; p < 0.001). On the contrary, samples from healthy women showed a high presence of residues of endrin compared with samples from affected women (58 vs. 0%, respectively) (Table 2). Interestingly, these differences were observed also in the subgroup of subjects older than 45 years old (Table 3). The relative prevalence of OCPs in both groups of women is summarized in Figure 2.


Complex organochlorine pesticide mixtures as determinant factor for breast cancer risk: a population-based case-control study in the Canary Islands (Spain).

Boada LD, Zumbado M, Henríquez-Hernández LA, Almeida-González M, Alvarez-León EE, Serra-Majem L, Luzardo OP - Environ Health (2012)

Frequency of detection of organochlorine pesticides among breast cancer patients and healthy women.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3403884&req=5

Figure 2: Frequency of detection of organochlorine pesticides among breast cancer patients and healthy women.
Mentions: As shown in Table 2, DDE (the main DDT-metabolite) was detected in most samples from healthy women and BC patients (89 and 97%, respectively). The other DDT-metabolite, DDD, was also found in a high number of serum samples (72%) from women suffering BC, but it was detected in a small number of healthy subjects (6%) (p < 0.001). Interestingly, the main component of technical DDT (p,p´-DDT), used in commercial formulations of DDT and banned in Spain in last 1970’s, was present in more than 70% of the samples from both groups of women. With respect to non-DDT-derivatives, we observed discrepant results. Thus, despite the fact that the presence of residues of lindane and dieldrin was similar in both groups of women (more than 20% in both cases), the percentage of samples showing detectable levels of aldrin was clearly higher in BC patients than in healthy women (74 vs. 38%; p < 0.001). On the contrary, samples from healthy women showed a high presence of residues of endrin compared with samples from affected women (58 vs. 0%, respectively) (Table 2). Interestingly, these differences were observed also in the subgroup of subjects older than 45 years old (Table 3). The relative prevalence of OCPs in both groups of women is summarized in Figure 2.

Bottom Line: Exposure to organochlorine pesticides has been linked to an increased incidence of the disease, although not all data have been consistent.Most published studies evaluated the exposure to organochlorines individually, ignoring the potential effects exerted by the mixtures of chemicals.The most prevalent mixture of organochlorines among healthy women was the combination of lindane and endrin, and this mixture was not detected in any affected women.

View Article: PubMed Central - HTML - PubMed

Affiliation: Dpt of Clinical Sciences, Universidad de Las Palmas de Gran Canaria and Instituto Canario de Investigación del Cáncer-ICIC, P.O. Box 550, Las Palmas de Gran Canaria 35080, Spain. ldominguez@dcc.ulpgc.es

ABSTRACT

Background: All the relevant risk factors contributing to breast cancer etiology are not fully known. Exposure to organochlorine pesticides has been linked to an increased incidence of the disease, although not all data have been consistent. Most published studies evaluated the exposure to organochlorines individually, ignoring the potential effects exerted by the mixtures of chemicals.

Methods: This population-based study was designed to evaluate the profile of mixtures of organochlorines detected in 103 healthy women and 121 women diagnosed with breast cancer from Gran Canaria Island, and the relation between the exposure to these compounds and breast cancer risk.

Results: The most prevalent mixture of organochlorines among healthy women was the combination of lindane and endrin, and this mixture was not detected in any affected women. Breast cancer patients presented more frequently a combination of aldrin, dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD), and this mixture was not found in any healthy woman. After adjusting for covariables, the risk of breast cancer was moderately associated with DDD (OR = 1.008, confidence interval 95% 1.001-1.015, p = 0.024).

Conclusions: This study indicates that healthy women show a very different profile of organochlorine pesticide mixtures than breast cancer patients, suggesting that organochlorine pesticide mixtures could play a relevant role in breast cancer risk.

Show MeSH
Related in: MedlinePlus