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Effect of hydroxyapatite on the physicochemical characteristics of a gentamicin-loaded monoolein gel intended to treat chronic osteomyelitis.

Semdé R, Gondi RF, Sombié BC, Yaméogo BG, Ouédraogo M - J Adv Pharm Technol Res (2012)

Bottom Line: Many works have demonstrated the real potential of gentamicin-monoolein-water formulations as bioresorbable and sustained-release implants for the local treatment of the chronic osteomyelitis.The rheological, thermal (differential scanning calorimetric and thermogravimetric diffraction analysis), X-ray diffraction, and dissolution studies have showed that the presence of hydroxyapatite does not dramatically disturb the cubic liquid crystalline structure of the monoolein-water gel and their ability to progressively release the antibiotic.Implant 20% that was capable to release gentamicin sulfate over a period of four weeks without marked burst effect could be used as a more suitable biodegradable delivery system for the local management of chronic osteomyelitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Pharmaceutical Sciences, UFR/SDSS, University of Ouagadougou, 03 BP 7021 Ouagadougou 03, Burkina Faso, West Africa.

ABSTRACT
Many works have demonstrated the real potential of gentamicin-monoolein-water formulations as bioresorbable and sustained-release implants for the local treatment of the chronic osteomyelitis. In order to improve the efficacy of this type of implant, the incorporation of hydroxyapatite, a well-known osteointegrator material, is thought to be an interesting approach. Five formulations incorporating 0, 2.5, 5, 10, and 20% of hydroxyapatite were examined with regard to their physicochemical and in vitro drug release characteristics. The rheological, thermal (differential scanning calorimetric and thermogravimetric diffraction analysis), X-ray diffraction, and dissolution studies have showed that the presence of hydroxyapatite does not dramatically disturb the cubic liquid crystalline structure of the monoolein-water gel and their ability to progressively release the antibiotic. Implant 20% that was capable to release gentamicin sulfate over a period of four weeks without marked burst effect could be used as a more suitable biodegradable delivery system for the local management of chronic osteomyelitis.

No MeSH data available.


Related in: MedlinePlus

X-ray diffraction spectra of implants 0%, 2.5%, 5%, 10%, and 20%, from the bottom to the top of the graph
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Figure 3: X-ray diffraction spectra of implants 0%, 2.5%, 5%, 10%, and 20%, from the bottom to the top of the graph

Mentions: The XRD patterns of all the implants [Figure 3] display two peaks in the range from 2 to 20°, as shown with implants without hydroxyapatite by Ouédraogo et al.[2] Therefore, the presence of hydroxyapatite does not destroy the liquid crystal structure of the monoolein implants. However, other peaks of which the intensities increased with the hydroxyapatite content in the implant appeared in the range from 25 to 50°.


Effect of hydroxyapatite on the physicochemical characteristics of a gentamicin-loaded monoolein gel intended to treat chronic osteomyelitis.

Semdé R, Gondi RF, Sombié BC, Yaméogo BG, Ouédraogo M - J Adv Pharm Technol Res (2012)

X-ray diffraction spectra of implants 0%, 2.5%, 5%, 10%, and 20%, from the bottom to the top of the graph
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3401670&req=5

Figure 3: X-ray diffraction spectra of implants 0%, 2.5%, 5%, 10%, and 20%, from the bottom to the top of the graph
Mentions: The XRD patterns of all the implants [Figure 3] display two peaks in the range from 2 to 20°, as shown with implants without hydroxyapatite by Ouédraogo et al.[2] Therefore, the presence of hydroxyapatite does not destroy the liquid crystal structure of the monoolein implants. However, other peaks of which the intensities increased with the hydroxyapatite content in the implant appeared in the range from 25 to 50°.

Bottom Line: Many works have demonstrated the real potential of gentamicin-monoolein-water formulations as bioresorbable and sustained-release implants for the local treatment of the chronic osteomyelitis.The rheological, thermal (differential scanning calorimetric and thermogravimetric diffraction analysis), X-ray diffraction, and dissolution studies have showed that the presence of hydroxyapatite does not dramatically disturb the cubic liquid crystalline structure of the monoolein-water gel and their ability to progressively release the antibiotic.Implant 20% that was capable to release gentamicin sulfate over a period of four weeks without marked burst effect could be used as a more suitable biodegradable delivery system for the local management of chronic osteomyelitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Pharmaceutical Sciences, UFR/SDSS, University of Ouagadougou, 03 BP 7021 Ouagadougou 03, Burkina Faso, West Africa.

ABSTRACT
Many works have demonstrated the real potential of gentamicin-monoolein-water formulations as bioresorbable and sustained-release implants for the local treatment of the chronic osteomyelitis. In order to improve the efficacy of this type of implant, the incorporation of hydroxyapatite, a well-known osteointegrator material, is thought to be an interesting approach. Five formulations incorporating 0, 2.5, 5, 10, and 20% of hydroxyapatite were examined with regard to their physicochemical and in vitro drug release characteristics. The rheological, thermal (differential scanning calorimetric and thermogravimetric diffraction analysis), X-ray diffraction, and dissolution studies have showed that the presence of hydroxyapatite does not dramatically disturb the cubic liquid crystalline structure of the monoolein-water gel and their ability to progressively release the antibiotic. Implant 20% that was capable to release gentamicin sulfate over a period of four weeks without marked burst effect could be used as a more suitable biodegradable delivery system for the local management of chronic osteomyelitis.

No MeSH data available.


Related in: MedlinePlus