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Etiopathogenetic mechanisms of pulmonary hypertension in sleep-related breathing disorders.

Adegunsoye A, Ramachandran S - Pulm Med (2012)

Bottom Line: Obstructive sleep apnea syndrome is a common disorder with significant health consequences and is on the rise in consonance with the obesity pandemic.In view of the association between sleep-disordered breathing and pulmonary hypertension as depicted by multiple studies, current clinical practice guidelines categorize obstructive sleep apnea as a risk factor for pulmonary hypertension and recommend an assessment for sleep disordered breathing in evaluating patients with pulmonary hypertension.The dysregulatory mechanisms associated with hypoxemic episodes observed in sleep related breathing disorders contribute to the onset of pulmonary hypertension and identification of these potentially treatable factors might help in the reduction of overall cardiovascular mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Mercy Fitzgerald Hospital, Darby, PA 19018, USA.

ABSTRACT
Obstructive sleep apnea syndrome is a common disorder with significant health consequences and is on the rise in consonance with the obesity pandemic. In view of the association between sleep-disordered breathing and pulmonary hypertension as depicted by multiple studies, current clinical practice guidelines categorize obstructive sleep apnea as a risk factor for pulmonary hypertension and recommend an assessment for sleep disordered breathing in evaluating patients with pulmonary hypertension. The dysregulatory mechanisms associated with hypoxemic episodes observed in sleep related breathing disorders contribute to the onset of pulmonary hypertension and identification of these potentially treatable factors might help in the reduction of overall cardiovascular mortality.

No MeSH data available.


Related in: MedlinePlus

Pathogenesis of pulmonary hypertension [19, 21–23].
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Pathogenesis of pulmonary hypertension [19, 21–23].

Mentions: The pathological changes observed in PH due to hypoxia and SRBD include medial hypertrophy and obstructive proliferation of the tunica intima within the distal pulmonary arteries. The severity of intimal and medial thickening is highly variable and results in near total occlusion of these vessels. This results in major increments in the pulmonary vascular resistance and considerably impedes blood flow through the lungs. Regions of the lungs with significant emphysematous changes or fibrosis may exhibit substantial destruction of the pulmonary vascular bed. The disordered mechanisms resulting in the observed pathophysiological manifestations are multifactorial (Figure 1). Crucial factors which play a pivotal role in these processes include hypoxic vasoconstriction, mechanical changes resulting from hyper-inflated lungs, capillary loss, and inflammation. New evidence also points to the importance of an imbalance between endothelium-derived factors responsible for vasoconstriction and vasodilation [20].


Etiopathogenetic mechanisms of pulmonary hypertension in sleep-related breathing disorders.

Adegunsoye A, Ramachandran S - Pulm Med (2012)

Pathogenesis of pulmonary hypertension [19, 21–23].
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3401569&req=5

fig1: Pathogenesis of pulmonary hypertension [19, 21–23].
Mentions: The pathological changes observed in PH due to hypoxia and SRBD include medial hypertrophy and obstructive proliferation of the tunica intima within the distal pulmonary arteries. The severity of intimal and medial thickening is highly variable and results in near total occlusion of these vessels. This results in major increments in the pulmonary vascular resistance and considerably impedes blood flow through the lungs. Regions of the lungs with significant emphysematous changes or fibrosis may exhibit substantial destruction of the pulmonary vascular bed. The disordered mechanisms resulting in the observed pathophysiological manifestations are multifactorial (Figure 1). Crucial factors which play a pivotal role in these processes include hypoxic vasoconstriction, mechanical changes resulting from hyper-inflated lungs, capillary loss, and inflammation. New evidence also points to the importance of an imbalance between endothelium-derived factors responsible for vasoconstriction and vasodilation [20].

Bottom Line: Obstructive sleep apnea syndrome is a common disorder with significant health consequences and is on the rise in consonance with the obesity pandemic.In view of the association between sleep-disordered breathing and pulmonary hypertension as depicted by multiple studies, current clinical practice guidelines categorize obstructive sleep apnea as a risk factor for pulmonary hypertension and recommend an assessment for sleep disordered breathing in evaluating patients with pulmonary hypertension.The dysregulatory mechanisms associated with hypoxemic episodes observed in sleep related breathing disorders contribute to the onset of pulmonary hypertension and identification of these potentially treatable factors might help in the reduction of overall cardiovascular mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Mercy Fitzgerald Hospital, Darby, PA 19018, USA.

ABSTRACT
Obstructive sleep apnea syndrome is a common disorder with significant health consequences and is on the rise in consonance with the obesity pandemic. In view of the association between sleep-disordered breathing and pulmonary hypertension as depicted by multiple studies, current clinical practice guidelines categorize obstructive sleep apnea as a risk factor for pulmonary hypertension and recommend an assessment for sleep disordered breathing in evaluating patients with pulmonary hypertension. The dysregulatory mechanisms associated with hypoxemic episodes observed in sleep related breathing disorders contribute to the onset of pulmonary hypertension and identification of these potentially treatable factors might help in the reduction of overall cardiovascular mortality.

No MeSH data available.


Related in: MedlinePlus