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On the discovery, biological effects, and use of Cisplatin and metallocenes in anticancer chemotherapy.

Gómez-Ruiz S, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN - Bioinorg Chem Appl (2012)

Bottom Line: Molecular mechanisms of cisplatin interaction with DNA, DNA repair mechanisms, and cellular proteins are discussed.Molecular background of the sensitivity and resistance to cisplatin, as well as its influence on the efficacy of the antitumor immune response was evaluated.Furthermore, herein are summarized some metallocenes (titanocene, vanadocene, molybdocene, ferrocene, and zirconocene) with high antitumor activity.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Química Inorgánica y Analítica, E.S.C.E.T., Universidad Rey Juan Carlos, 28933 Móstoles, Spain.

ABSTRACT
The purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a brief outlook on the metallocene compounds as antitumor drugs as well as the future tendencies for the use of the latter in anticancer chemotherapy. Molecular mechanisms of cisplatin interaction with DNA, DNA repair mechanisms, and cellular proteins are discussed. Molecular background of the sensitivity and resistance to cisplatin, as well as its influence on the efficacy of the antitumor immune response was evaluated. Furthermore, herein are summarized some metallocenes (titanocene, vanadocene, molybdocene, ferrocene, and zirconocene) with high antitumor activity.

No MeSH data available.


Related in: MedlinePlus

Titanocene derivatives used in preclinical and clinical trials: (a) titanocene dichloride; (b) titanocene-Y; (c) alkenyl-substituted titanocene derivative; (d) titanocenyl complex; (e) titanocene derivative with alkylammonium substituents; (f) steroid-functionalized titanocene derivative.
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Related In: Results  -  Collection


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fig5: Titanocene derivatives used in preclinical and clinical trials: (a) titanocene dichloride; (b) titanocene-Y; (c) alkenyl-substituted titanocene derivative; (d) titanocenyl complex; (e) titanocene derivative with alkylammonium substituents; (f) steroid-functionalized titanocene derivative.

Mentions: Titanocene derivatives are together with ferrocene complexes the most studied metallocenes in the fight against cancer. The pioneering work of Köpf and Köpf-Maier in the early 1980's showed the antiproliferative properties of titanocene dichloride, [TiCp2Cl2] (Cp = η5-C5H5, Figure 5(a)). This compound was studied in phase I clinical trials in 1993 [75–77] using water soluble formulations developed by Medac GmbH (Germany) [78].


On the discovery, biological effects, and use of Cisplatin and metallocenes in anticancer chemotherapy.

Gómez-Ruiz S, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN - Bioinorg Chem Appl (2012)

Titanocene derivatives used in preclinical and clinical trials: (a) titanocene dichloride; (b) titanocene-Y; (c) alkenyl-substituted titanocene derivative; (d) titanocenyl complex; (e) titanocene derivative with alkylammonium substituents; (f) steroid-functionalized titanocene derivative.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3401524&req=5

fig5: Titanocene derivatives used in preclinical and clinical trials: (a) titanocene dichloride; (b) titanocene-Y; (c) alkenyl-substituted titanocene derivative; (d) titanocenyl complex; (e) titanocene derivative with alkylammonium substituents; (f) steroid-functionalized titanocene derivative.
Mentions: Titanocene derivatives are together with ferrocene complexes the most studied metallocenes in the fight against cancer. The pioneering work of Köpf and Köpf-Maier in the early 1980's showed the antiproliferative properties of titanocene dichloride, [TiCp2Cl2] (Cp = η5-C5H5, Figure 5(a)). This compound was studied in phase I clinical trials in 1993 [75–77] using water soluble formulations developed by Medac GmbH (Germany) [78].

Bottom Line: Molecular mechanisms of cisplatin interaction with DNA, DNA repair mechanisms, and cellular proteins are discussed.Molecular background of the sensitivity and resistance to cisplatin, as well as its influence on the efficacy of the antitumor immune response was evaluated.Furthermore, herein are summarized some metallocenes (titanocene, vanadocene, molybdocene, ferrocene, and zirconocene) with high antitumor activity.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Química Inorgánica y Analítica, E.S.C.E.T., Universidad Rey Juan Carlos, 28933 Móstoles, Spain.

ABSTRACT
The purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a brief outlook on the metallocene compounds as antitumor drugs as well as the future tendencies for the use of the latter in anticancer chemotherapy. Molecular mechanisms of cisplatin interaction with DNA, DNA repair mechanisms, and cellular proteins are discussed. Molecular background of the sensitivity and resistance to cisplatin, as well as its influence on the efficacy of the antitumor immune response was evaluated. Furthermore, herein are summarized some metallocenes (titanocene, vanadocene, molybdocene, ferrocene, and zirconocene) with high antitumor activity.

No MeSH data available.


Related in: MedlinePlus