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CCL3L1 copy number and susceptibility to malaria.

Carpenter D, Färnert A, Rooth I, Armour JA, Shaw MA - Infect. Genet. Evol. (2012)

Bottom Line: Copy number of CCL3L1 was measured using the paralogue ratio test (PRT) and the dataset exhibited copy numbers ranging between 1 and 10 copies per diploid genome (pdg).Furthermore, we were able to identify copy number haplotypes in some families, using microsatellites within the copy variable region, for transmission disequilibrium testing.We identified a high level of copy number haplotype diversity and find some evidence for an association of low CCL3L1 copy number with protection from anaemia.

View Article: PubMed Central - PubMed

Affiliation: Centre for Genetics and Genomics, School of Biology, University of Nottingham, Nottingham NG7 2UH, UK. danielle.carpenter@nottingham.ac.uk

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Distribution of the haemoglobin data before and after correction for age, sex and parasite load. The residuals generated from the correction were normally distributed and therefore no further transformation was made prior to genetic analysis.
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f0015: Distribution of the haemoglobin data before and after correction for age, sex and parasite load. The residuals generated from the correction were normally distributed and therefore no further transformation was made prior to genetic analysis.

Mentions: The population surveys contain information on haemoglobin concentration (g/l) for years 1994 to 1999. The majority of the 1289 individuals recorded in the population surveys do not have data from all years, but individuals have an average of 1.75 entries (range 1–4). To generate a single quantitative trait from the longitudinal haemoglobin data the mean haemoglobin was calculated per sample. Age and sex correction was carried out annually using a general linear model with age, age2 and sex as covariates. A small proportion (1%) of these individuals also presented with clinical episodes at the time of survey, when cross referenced with the clinical episode records for March to May, and for these samples only the peak parasite load (parasite/μl) was also included as a covariate in the general linear model to take into account the effect of parasite load on haemoglobin values. The residuals were recorded for each year (1994–1999) and the arithmetic mean was subsequently calculated to give a single quantitative value for haemoglobin level (see Fig. 3) (Carpenter, 2003).


CCL3L1 copy number and susceptibility to malaria.

Carpenter D, Färnert A, Rooth I, Armour JA, Shaw MA - Infect. Genet. Evol. (2012)

Distribution of the haemoglobin data before and after correction for age, sex and parasite load. The residuals generated from the correction were normally distributed and therefore no further transformation was made prior to genetic analysis.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3401375&req=5

f0015: Distribution of the haemoglobin data before and after correction for age, sex and parasite load. The residuals generated from the correction were normally distributed and therefore no further transformation was made prior to genetic analysis.
Mentions: The population surveys contain information on haemoglobin concentration (g/l) for years 1994 to 1999. The majority of the 1289 individuals recorded in the population surveys do not have data from all years, but individuals have an average of 1.75 entries (range 1–4). To generate a single quantitative trait from the longitudinal haemoglobin data the mean haemoglobin was calculated per sample. Age and sex correction was carried out annually using a general linear model with age, age2 and sex as covariates. A small proportion (1%) of these individuals also presented with clinical episodes at the time of survey, when cross referenced with the clinical episode records for March to May, and for these samples only the peak parasite load (parasite/μl) was also included as a covariate in the general linear model to take into account the effect of parasite load on haemoglobin values. The residuals were recorded for each year (1994–1999) and the arithmetic mean was subsequently calculated to give a single quantitative value for haemoglobin level (see Fig. 3) (Carpenter, 2003).

Bottom Line: Copy number of CCL3L1 was measured using the paralogue ratio test (PRT) and the dataset exhibited copy numbers ranging between 1 and 10 copies per diploid genome (pdg).Furthermore, we were able to identify copy number haplotypes in some families, using microsatellites within the copy variable region, for transmission disequilibrium testing.We identified a high level of copy number haplotype diversity and find some evidence for an association of low CCL3L1 copy number with protection from anaemia.

View Article: PubMed Central - PubMed

Affiliation: Centre for Genetics and Genomics, School of Biology, University of Nottingham, Nottingham NG7 2UH, UK. danielle.carpenter@nottingham.ac.uk

Show MeSH
Related in: MedlinePlus