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Atypical symptoms in patients with gastroesophageal reflux disease.

Yi CH, Liu TT, Chen CL - J Neurogastroenterol Motil (2012)

Bottom Line: In all subjects, heartburn was associated with dysphagia (r = 0.16, P = 0.01), dyspepsia (r = 0.22, P = 0.008) and hiccup (r = 0.19, P = 0.003), whereas acid regurgitation was associated with dyspepsia (r = 0.21, P = 0.014), belching (r = 0.15, P = 0.018) and hiccup (r = 0.19, P = 0.002).Atypical symptoms did not correlate with the presence of histological esophagitis.The existence of atypical symptoms appears to be associated with the presence of typical reflux symptoms irrespective of endoscopic and histological reflux esophagitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.

ABSTRACT

Background/aims: Atypical symptoms are common in gastroesophageal reflux disease (GERD). Patients with non-erosive reflux disease (NERD) and erosive reflux disease (ERD) exhibit different clinical characteristics and responses to acid suppression treatment. We aimed to compare atypical characteristics in patients with NERD and ERD. We also investigated the presence of histological esophagitis in patients with NERD and ERD.

Methods: Eligible patients completed a questionnaire regarding reflux symptoms and concomitant atypical symptoms. Endoscopic biopsies with histological examination were performed.

Results: Of the 210 patients with GERD, 90 patients with ERD and 120 patients with NERD were studied. ERD patients were characterized by higher prevalence of hiatal hernia (P = 0.001) and smoking (P = 0.047). The prevalence of GERD was greater in the age group between 41 and 60 years regardless of endoscopic finding. There was no difference in the prevalence of atypical symptoms or histological esophagitis between NERD and ERD. In all subjects, heartburn was associated with dysphagia (r = 0.16, P = 0.01), dyspepsia (r = 0.22, P = 0.008) and hiccup (r = 0.19, P = 0.003), whereas acid regurgitation was associated with dyspepsia (r = 0.21, P = 0.014), belching (r = 0.15, P = 0.018) and hiccup (r = 0.19, P = 0.002).

Conclusions: Atypical symptoms did not correlate with the presence of histological esophagitis. Atypical symptoms were equally prevalent in patients with NERD and ERD. The existence of atypical symptoms appears to be associated with the presence of typical reflux symptoms irrespective of endoscopic and histological reflux esophagitis.

No MeSH data available.


Related in: MedlinePlus

Histological esophagitis in proximal and distal esophagus. Histological esophagitis occurred similarly between patients with erosive reflux disease and non-erosive reflux disease for proximal or distal esophagus. NERD, non-erosive reflux disease; ERD, erosive reflux disease.
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Figure 3: Histological esophagitis in proximal and distal esophagus. Histological esophagitis occurred similarly between patients with erosive reflux disease and non-erosive reflux disease for proximal or distal esophagus. NERD, non-erosive reflux disease; ERD, erosive reflux disease.

Mentions: Histological esophagitis in the proximal esophagus was detected in 45.9% of patients, whereas 51.9% of patients had histological esophagitis in distal esophagus. No significant difference was observed in the presence of histological esophagitis between patients with ERD and NERD for either proximal or distal esophagus (Fig. 3). In addition, the presence of histological esophagitis did not correlate with any of atypical symptoms.


Atypical symptoms in patients with gastroesophageal reflux disease.

Yi CH, Liu TT, Chen CL - J Neurogastroenterol Motil (2012)

Histological esophagitis in proximal and distal esophagus. Histological esophagitis occurred similarly between patients with erosive reflux disease and non-erosive reflux disease for proximal or distal esophagus. NERD, non-erosive reflux disease; ERD, erosive reflux disease.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3400815&req=5

Figure 3: Histological esophagitis in proximal and distal esophagus. Histological esophagitis occurred similarly between patients with erosive reflux disease and non-erosive reflux disease for proximal or distal esophagus. NERD, non-erosive reflux disease; ERD, erosive reflux disease.
Mentions: Histological esophagitis in the proximal esophagus was detected in 45.9% of patients, whereas 51.9% of patients had histological esophagitis in distal esophagus. No significant difference was observed in the presence of histological esophagitis between patients with ERD and NERD for either proximal or distal esophagus (Fig. 3). In addition, the presence of histological esophagitis did not correlate with any of atypical symptoms.

Bottom Line: In all subjects, heartburn was associated with dysphagia (r = 0.16, P = 0.01), dyspepsia (r = 0.22, P = 0.008) and hiccup (r = 0.19, P = 0.003), whereas acid regurgitation was associated with dyspepsia (r = 0.21, P = 0.014), belching (r = 0.15, P = 0.018) and hiccup (r = 0.19, P = 0.002).Atypical symptoms did not correlate with the presence of histological esophagitis.The existence of atypical symptoms appears to be associated with the presence of typical reflux symptoms irrespective of endoscopic and histological reflux esophagitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.

ABSTRACT

Background/aims: Atypical symptoms are common in gastroesophageal reflux disease (GERD). Patients with non-erosive reflux disease (NERD) and erosive reflux disease (ERD) exhibit different clinical characteristics and responses to acid suppression treatment. We aimed to compare atypical characteristics in patients with NERD and ERD. We also investigated the presence of histological esophagitis in patients with NERD and ERD.

Methods: Eligible patients completed a questionnaire regarding reflux symptoms and concomitant atypical symptoms. Endoscopic biopsies with histological examination were performed.

Results: Of the 210 patients with GERD, 90 patients with ERD and 120 patients with NERD were studied. ERD patients were characterized by higher prevalence of hiatal hernia (P = 0.001) and smoking (P = 0.047). The prevalence of GERD was greater in the age group between 41 and 60 years regardless of endoscopic finding. There was no difference in the prevalence of atypical symptoms or histological esophagitis between NERD and ERD. In all subjects, heartburn was associated with dysphagia (r = 0.16, P = 0.01), dyspepsia (r = 0.22, P = 0.008) and hiccup (r = 0.19, P = 0.003), whereas acid regurgitation was associated with dyspepsia (r = 0.21, P = 0.014), belching (r = 0.15, P = 0.018) and hiccup (r = 0.19, P = 0.002).

Conclusions: Atypical symptoms did not correlate with the presence of histological esophagitis. Atypical symptoms were equally prevalent in patients with NERD and ERD. The existence of atypical symptoms appears to be associated with the presence of typical reflux symptoms irrespective of endoscopic and histological reflux esophagitis.

No MeSH data available.


Related in: MedlinePlus