β band stability over time correlates with Parkinsonian rigidity and bradykinesia.
Bottom Line: The CV of activity in the high beta frequency band was found to be correlated with clinical state off levodopa (rho=-0.59, p<0.001) and this was shown to be complementary, rather than redundant, to spectral amplitude in a multiple regression analysis, selective for rigidity-bradykinesia and highly focal.Similarly, a strong correlation was found between change in clinical scores and change in high beta CV following levodopa (rho=-0.66, p=0.004).Our results indicate that temporal stability in the beta band is correlated with rigidity-bradykinesia.
Affiliation: Department of Clinical Neurology, Oxford University, 6th Floor, West wing, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK. firstname.lastname@example.orgShow MeSH
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Mentions: Despite the above, we found a significant negative correlation between the levodopa-induced change in mean beta 2 CV and the change in contralateral rigidity–bradykinesia scores (rho = − 0.66, p = 0.004; Fig. 4). Greater increases in CV upon treatment were associated with greater improvements in rigidity–bradykinesia upon treatment. This was again found to be symptom selective as there was no relationship between beta 2 CV and contralateral tremor hemibody scores (rho = 0.14, p = 0.6). There was also no significant association between change in beta 1 CV and change in clinical state. Note too that the change in CV cannot alone account for improvement in clinical state with medication, as a minority of patients showed modest improvement despite drops in CV after treatment. On two sides, each from different patients, the drop in CV after treatment related to the complete suppression of the beta 2 peak that was formerly present in the off medication state.
Affiliation: Department of Clinical Neurology, Oxford University, 6th Floor, West wing, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK. email@example.com