Limits...
Introduction to paraoxonases.

Aviram M - J Lipids (2012)

View Article: PubMed Central - PubMed

Affiliation: The Lipid Research Laboratory, Rambam Medical Center, Bat-Galim, 31096 Haifa, Israel.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

PONs play a clear protective role against cardiovascular diseases... Major cardioprotective PON characteristics include, beside their potent antioxidant properties, the following: for PON 1, favorable effects on macrophage cholesterol metabolism, for PON 2, attenuation of macrophage triglyceride accumulation, and for PON 3, improvement in bile acids metabolism... Human serum HDL-associated paraoxonase (PON1) is an esterase that possesses cardiovascular protective properties which result in the following antiatherogenic functions: (1) attenuated oxidative stress in serum, in lipoproteins, in macrophages, and in atherosclerotic lesions; (2) decreased oxidized LDL uptake by macrophages; (3) inhibited macrophage cholesterol biosynthesis rate; (4) stimulated HDL-mediated cholesterol efflux from macrophages... Major PON1 inactivators (and reversal of their action) include (1) oxidative stress (and reversal effect by antioxidants such as the pomegranate polyphenolic tannin punicalagin); (2) high cholesterol (and reversal effect by statins); (3) high triglycerides (and reversal effect by fibrates); (4) high glucose (and reversal effect by insulin)... Macrophage PON2 regulation (as related to atherogenesis) differs from that of serum PON 1 in the following characteristics: (1) stimulation (not inhibition as shown for PON1) by oxidative stress and also by anti oxidants (like PON1); (2) stimulation by high glucose (PON1 is inhibited) and also by insulin (like PON1); (3) stimulation by urokinase plasminogen activator (uPA); (4) stimulation by high triglycerides (PON1 is inhibited); (5) stimulation by arachidonic acid and also by its product prostaglandin E2 (like PON1); (6) inhibition by high cholesterol and reversal effect by statins (like PON1)... Reduction in specific oxidized lipids in the blood, in arterial lipoproteins (LDL, HDL), and in macrophages, by overexpressing humoral PON1 (and also cellular PON2), could thus be important target for the attenuation of atherosclerosis development... Michael Aviram

No MeSH data available.


© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3379150&req=5

Mentions: Figure 1 summarizes our current view on the antiatherosclerotic properties of circulatory HDL-bound PON1 and those of cellular PON2. Reduction in specific oxidized lipids in the blood, in arterial lipoproteins (LDL, HDL), and in macrophages, by overexpressing humoral PON1 (and also cellular PON2), could thus be important target for the attenuation of atherosclerosis development.


Introduction to paraoxonases.

Aviram M - J Lipids (2012)

© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3379150&req=5

Mentions: Figure 1 summarizes our current view on the antiatherosclerotic properties of circulatory HDL-bound PON1 and those of cellular PON2. Reduction in specific oxidized lipids in the blood, in arterial lipoproteins (LDL, HDL), and in macrophages, by overexpressing humoral PON1 (and also cellular PON2), could thus be important target for the attenuation of atherosclerosis development.

View Article: PubMed Central - PubMed

Affiliation: The Lipid Research Laboratory, Rambam Medical Center, Bat-Galim, 31096 Haifa, Israel.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

PONs play a clear protective role against cardiovascular diseases... Major cardioprotective PON characteristics include, beside their potent antioxidant properties, the following: for PON 1, favorable effects on macrophage cholesterol metabolism, for PON 2, attenuation of macrophage triglyceride accumulation, and for PON 3, improvement in bile acids metabolism... Human serum HDL-associated paraoxonase (PON1) is an esterase that possesses cardiovascular protective properties which result in the following antiatherogenic functions: (1) attenuated oxidative stress in serum, in lipoproteins, in macrophages, and in atherosclerotic lesions; (2) decreased oxidized LDL uptake by macrophages; (3) inhibited macrophage cholesterol biosynthesis rate; (4) stimulated HDL-mediated cholesterol efflux from macrophages... Major PON1 inactivators (and reversal of their action) include (1) oxidative stress (and reversal effect by antioxidants such as the pomegranate polyphenolic tannin punicalagin); (2) high cholesterol (and reversal effect by statins); (3) high triglycerides (and reversal effect by fibrates); (4) high glucose (and reversal effect by insulin)... Macrophage PON2 regulation (as related to atherogenesis) differs from that of serum PON 1 in the following characteristics: (1) stimulation (not inhibition as shown for PON1) by oxidative stress and also by anti oxidants (like PON1); (2) stimulation by high glucose (PON1 is inhibited) and also by insulin (like PON1); (3) stimulation by urokinase plasminogen activator (uPA); (4) stimulation by high triglycerides (PON1 is inhibited); (5) stimulation by arachidonic acid and also by its product prostaglandin E2 (like PON1); (6) inhibition by high cholesterol and reversal effect by statins (like PON1)... Reduction in specific oxidized lipids in the blood, in arterial lipoproteins (LDL, HDL), and in macrophages, by overexpressing humoral PON1 (and also cellular PON2), could thus be important target for the attenuation of atherosclerosis development... Michael Aviram

No MeSH data available.