Tumor cell and carcinoma-associated fibroblast interaction regulates matrix metalloproteinases and their inhibitors in oral squamous cell carcinoma.
Bottom Line: In addition, these cells also cooperated in activation of MMP pro-enzymes.It is particularly interesting that the fibroblast-produced inactive MMP-2 has been activated by the tumor-cell-produced membrane-type 1 matrix metalloproteinase (MT1-MMP).The crosstalk between cancer- and the surrounding fibroblast stromal-cells is essential for the fine tuning of cancer cells invasivity.
Affiliation: 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, 1085 Budapest, Hungary. firstname.lastname@example.orgShow MeSH
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Mentions: A continuous interaction between tumor cells and fibroblasts was hypothesized in the regulation of MMP and TIMP expression and activity. The expression of MMPs and TIMPs was expected in the PDL fibroblasts, whose regulation was hypothesized to occur via inflammatory cytokines, including IL1-β , produced by SCC-25 cells. In the regulation of MMP-9 gene expression the fibronectin–integrin αvβ6 (ITGA5B6) pathway was hypothesized. Another possible pathway, especially in regulation of TIMP expression, is the TGF-β1-pathway [31,32]; the expression of TGF-β1 was expected in the fibroblasts and in the tumor cells (Fig. 1).
Affiliation: 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, 1085 Budapest, Hungary. email@example.com