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Behavioral and electrophysiological effects of transcranial direct current stimulation of the parietal cortex in a visuo-spatial working memory task.

Heimrath K, Sandmann P, Becke A, Müller NG, Zaehle T - Front Psychiatry (2012)

Bottom Line: The results showed that tDCS modulated WM performance and its underlying electrophysiological brain activity in a polarity-specific way.This result can be considered an important step toward a better understanding of the mechanisms involved in tDCS-induced modulations of cognitive processing.This is of particular importance for the application of electrical brain stimulation as a therapeutic treatment of neuropsychiatric deficits in clinical populations.

View Article: PubMed Central - PubMed

Affiliation: Section of Neuropsychology, Department of Neurology, Otto-von-Guericke University Magdeburg Magdeburg, Germany.

ABSTRACT
Impairments of working memory (WM) performance are frequent concomitant symptoms in several psychiatric and neurologic diseases. Despite the great advance in treating the reduced WM abilities in patients suffering from, e.g., Parkinson's and Alzheimer's disease by means of transcranial direct current stimulation (tDCS), the exact neurophysiological underpinning subserving these therapeutic tDCS-effects are still unknown. In the present study we investigated the impact of tDCS on performance in a visuo-spatial WM task and its underlying neural activity. In three experimental sessions, participants performed a delayed matching-to-sample WM task after sham, anodal, and cathodal tDCS over the right parietal cortex. The results showed that tDCS modulated WM performance and its underlying electrophysiological brain activity in a polarity-specific way. Parietal tDCS altered event-related potentials and oscillatory power in the alpha band at posterior electrode sites. The present study demonstrates that posterior tDCS can alter visuo-spatial WM performance by modulating the underlying neural activity. This result can be considered an important step toward a better understanding of the mechanisms involved in tDCS-induced modulations of cognitive processing. This is of particular importance for the application of electrical brain stimulation as a therapeutic treatment of neuropsychiatric deficits in clinical populations.

No MeSH data available.


Related in: MedlinePlus

Transcranial direct current stimulation effect on event-related potentials (ERPs): Grand average scalp-recorded ERPs are given for anodal, cathodal, and sham conditions for stimuli attended in the left and right hemifield. ERPs are averaged over 12 subjects for the posterior electrodes P3, P4, Pz, O1, and O2. ERP topographies of grand averages across all conditions are given separately for the N2 (150 ms), P2 (230 ms), N3 (300 ms), and SPCN (1650 ms).
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Figure 3: Transcranial direct current stimulation effect on event-related potentials (ERPs): Grand average scalp-recorded ERPs are given for anodal, cathodal, and sham conditions for stimuli attended in the left and right hemifield. ERPs are averaged over 12 subjects for the posterior electrodes P3, P4, Pz, O1, and O2. ERP topographies of grand averages across all conditions are given separately for the N2 (150 ms), P2 (230 ms), N3 (300 ms), and SPCN (1650 ms).

Mentions: Figure 3 illustrates the ERP data for anodal, cathodal, and sham conditions for stimuli attended in the left and right hemifield averaged over 12 subjects for the analyzed electrodes (P3, P4, Pz, O1, O2). Visual stimulation consistently evoked a N2 component at 150 ms which was followed by the P2 component at 230 ms. A N3 component was elicited consistently in all tDCS conditions with a mean latency of 300 ms which was followed by an SPCN component between 600 and 700 ms.


Behavioral and electrophysiological effects of transcranial direct current stimulation of the parietal cortex in a visuo-spatial working memory task.

Heimrath K, Sandmann P, Becke A, Müller NG, Zaehle T - Front Psychiatry (2012)

Transcranial direct current stimulation effect on event-related potentials (ERPs): Grand average scalp-recorded ERPs are given for anodal, cathodal, and sham conditions for stimuli attended in the left and right hemifield. ERPs are averaged over 12 subjects for the posterior electrodes P3, P4, Pz, O1, and O2. ERP topographies of grand averages across all conditions are given separately for the N2 (150 ms), P2 (230 ms), N3 (300 ms), and SPCN (1650 ms).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3378949&req=5

Figure 3: Transcranial direct current stimulation effect on event-related potentials (ERPs): Grand average scalp-recorded ERPs are given for anodal, cathodal, and sham conditions for stimuli attended in the left and right hemifield. ERPs are averaged over 12 subjects for the posterior electrodes P3, P4, Pz, O1, and O2. ERP topographies of grand averages across all conditions are given separately for the N2 (150 ms), P2 (230 ms), N3 (300 ms), and SPCN (1650 ms).
Mentions: Figure 3 illustrates the ERP data for anodal, cathodal, and sham conditions for stimuli attended in the left and right hemifield averaged over 12 subjects for the analyzed electrodes (P3, P4, Pz, O1, O2). Visual stimulation consistently evoked a N2 component at 150 ms which was followed by the P2 component at 230 ms. A N3 component was elicited consistently in all tDCS conditions with a mean latency of 300 ms which was followed by an SPCN component between 600 and 700 ms.

Bottom Line: The results showed that tDCS modulated WM performance and its underlying electrophysiological brain activity in a polarity-specific way.This result can be considered an important step toward a better understanding of the mechanisms involved in tDCS-induced modulations of cognitive processing.This is of particular importance for the application of electrical brain stimulation as a therapeutic treatment of neuropsychiatric deficits in clinical populations.

View Article: PubMed Central - PubMed

Affiliation: Section of Neuropsychology, Department of Neurology, Otto-von-Guericke University Magdeburg Magdeburg, Germany.

ABSTRACT
Impairments of working memory (WM) performance are frequent concomitant symptoms in several psychiatric and neurologic diseases. Despite the great advance in treating the reduced WM abilities in patients suffering from, e.g., Parkinson's and Alzheimer's disease by means of transcranial direct current stimulation (tDCS), the exact neurophysiological underpinning subserving these therapeutic tDCS-effects are still unknown. In the present study we investigated the impact of tDCS on performance in a visuo-spatial WM task and its underlying neural activity. In three experimental sessions, participants performed a delayed matching-to-sample WM task after sham, anodal, and cathodal tDCS over the right parietal cortex. The results showed that tDCS modulated WM performance and its underlying electrophysiological brain activity in a polarity-specific way. Parietal tDCS altered event-related potentials and oscillatory power in the alpha band at posterior electrode sites. The present study demonstrates that posterior tDCS can alter visuo-spatial WM performance by modulating the underlying neural activity. This result can be considered an important step toward a better understanding of the mechanisms involved in tDCS-induced modulations of cognitive processing. This is of particular importance for the application of electrical brain stimulation as a therapeutic treatment of neuropsychiatric deficits in clinical populations.

No MeSH data available.


Related in: MedlinePlus