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Morphometric classification and spatial organization of spiral ganglion neurons in the human cochlea: consequences for single fiber response to electrical stimulation.

Potrusil T, Wenger C, Glueckert R, Schrott-Fischer A, Rattay F - Neuroscience (2012)

Bottom Line: Results show that temporal parameters of the spiking pattern are affected by the size of the cell body.Cathodic stimulation was found to induce stronger variations of spikes while also leading to the lowest thresholds and longest latencies.Therefore, anodic stimulation leads to a more uniform excitation profile among SGCs with different cell body size.

View Article: PubMed Central - PubMed

Affiliation: Innsbruck Medical University, Department of Otorhinolaryngology, Laboratory for Inner Ear Biology, Anichstrasse 35, Innsbruck, Austria.

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Biphasic threshold stimulation by E3 of three neurons with different soma size. The traveling APs (lines from top to bottom correspond to the transmembrane potential of every compartment from the peripheral to the central end) are simulated for the smallest (d = 10.05 μm), mean value (d = 19.08 μm) and biggest detected cell (d = 25.05 μm).
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f0040: Biphasic threshold stimulation by E3 of three neurons with different soma size. The traveling APs (lines from top to bottom correspond to the transmembrane potential of every compartment from the peripheral to the central end) are simulated for the smallest (d = 10.05 μm), mean value (d = 19.08 μm) and biggest detected cell (d = 25.05 μm).

Mentions: When the soma-electrode distance is 0.5 mm, the cathodic threshold increases with soma diameter monotonically from −171 μA to −393 μA, always initiating the AP at compartment 13. Contrarily, the anodic threshold decreases monotonically from 174 μA to 162 μA with a constant IS at compartment 27. For the biphasic pulses of E3, the thresholds as well as the IS changes with varying soma diameter. When stimulated with biphasic cathodic first pulses, the thresholds again increase with cell size. The values range from −451 μA to −954 μA, although the slope of the curve decreases for diameters larger than 19.07 μm correlating with the change of IS from compartment 13 to 27 (compare top panel of Fig. 8). For biphasic anodic first pulses, this change appears already for diameters above 11.64 μm. As a result, the threshold values ascend steeply at first from 611 μA to 654 μA, but then again decrease to 635 μA (compare bottom panel of Fig. 8).


Morphometric classification and spatial organization of spiral ganglion neurons in the human cochlea: consequences for single fiber response to electrical stimulation.

Potrusil T, Wenger C, Glueckert R, Schrott-Fischer A, Rattay F - Neuroscience (2012)

Biphasic threshold stimulation by E3 of three neurons with different soma size. The traveling APs (lines from top to bottom correspond to the transmembrane potential of every compartment from the peripheral to the central end) are simulated for the smallest (d = 10.05 μm), mean value (d = 19.08 μm) and biggest detected cell (d = 25.05 μm).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3377987&req=5

f0040: Biphasic threshold stimulation by E3 of three neurons with different soma size. The traveling APs (lines from top to bottom correspond to the transmembrane potential of every compartment from the peripheral to the central end) are simulated for the smallest (d = 10.05 μm), mean value (d = 19.08 μm) and biggest detected cell (d = 25.05 μm).
Mentions: When the soma-electrode distance is 0.5 mm, the cathodic threshold increases with soma diameter monotonically from −171 μA to −393 μA, always initiating the AP at compartment 13. Contrarily, the anodic threshold decreases monotonically from 174 μA to 162 μA with a constant IS at compartment 27. For the biphasic pulses of E3, the thresholds as well as the IS changes with varying soma diameter. When stimulated with biphasic cathodic first pulses, the thresholds again increase with cell size. The values range from −451 μA to −954 μA, although the slope of the curve decreases for diameters larger than 19.07 μm correlating with the change of IS from compartment 13 to 27 (compare top panel of Fig. 8). For biphasic anodic first pulses, this change appears already for diameters above 11.64 μm. As a result, the threshold values ascend steeply at first from 611 μA to 654 μA, but then again decrease to 635 μA (compare bottom panel of Fig. 8).

Bottom Line: Results show that temporal parameters of the spiking pattern are affected by the size of the cell body.Cathodic stimulation was found to induce stronger variations of spikes while also leading to the lowest thresholds and longest latencies.Therefore, anodic stimulation leads to a more uniform excitation profile among SGCs with different cell body size.

View Article: PubMed Central - PubMed

Affiliation: Innsbruck Medical University, Department of Otorhinolaryngology, Laboratory for Inner Ear Biology, Anichstrasse 35, Innsbruck, Austria.

Show MeSH
Related in: MedlinePlus