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Morphometric classification and spatial organization of spiral ganglion neurons in the human cochlea: consequences for single fiber response to electrical stimulation.

Potrusil T, Wenger C, Glueckert R, Schrott-Fischer A, Rattay F - Neuroscience (2012)

Bottom Line: Results show that temporal parameters of the spiking pattern are affected by the size of the cell body.Cathodic stimulation was found to induce stronger variations of spikes while also leading to the lowest thresholds and longest latencies.Therefore, anodic stimulation leads to a more uniform excitation profile among SGCs with different cell body size.

View Article: PubMed Central - PubMed

Affiliation: Innsbruck Medical University, Department of Otorhinolaryngology, Laboratory for Inner Ear Biology, Anichstrasse 35, Innsbruck, Austria.

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Spike initiation sites depend on stimulus pulse type. The left side illustrates the compartment model of a target neuron with spike origin (horizontal arrows) at threshold for four different pulses. Stimulating electrode E1. Traveling APs are plotted at the right. Each line represents the temporal change in transmembrane potential. The top line is the neurons peripheral end, the soma is always plotted in yellow. The values for the time at which the spike occurs at the IS, the soma and the end of the model neuron are given in ms and they are marked by vertical arrows.
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f0030: Spike initiation sites depend on stimulus pulse type. The left side illustrates the compartment model of a target neuron with spike origin (horizontal arrows) at threshold for four different pulses. Stimulating electrode E1. Traveling APs are plotted at the right. Each line represents the temporal change in transmembrane potential. The top line is the neurons peripheral end, the soma is always plotted in yellow. The values for the time at which the spike occurs at the IS, the soma and the end of the model neuron are given in ms and they are marked by vertical arrows.

Mentions: These temporal parameters are displayed in Fig. 6 which demonstrates different spiking behavior when a selected model cell with d = 19.08 μm (which is the mean value of all evaluated diameters) is stimulated by electrode E1 with the four different pulse forms. The time courses of membrane potential of this cell are plotted for monophasic and biphasic threshold stimulations.


Morphometric classification and spatial organization of spiral ganglion neurons in the human cochlea: consequences for single fiber response to electrical stimulation.

Potrusil T, Wenger C, Glueckert R, Schrott-Fischer A, Rattay F - Neuroscience (2012)

Spike initiation sites depend on stimulus pulse type. The left side illustrates the compartment model of a target neuron with spike origin (horizontal arrows) at threshold for four different pulses. Stimulating electrode E1. Traveling APs are plotted at the right. Each line represents the temporal change in transmembrane potential. The top line is the neurons peripheral end, the soma is always plotted in yellow. The values for the time at which the spike occurs at the IS, the soma and the end of the model neuron are given in ms and they are marked by vertical arrows.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3377987&req=5

f0030: Spike initiation sites depend on stimulus pulse type. The left side illustrates the compartment model of a target neuron with spike origin (horizontal arrows) at threshold for four different pulses. Stimulating electrode E1. Traveling APs are plotted at the right. Each line represents the temporal change in transmembrane potential. The top line is the neurons peripheral end, the soma is always plotted in yellow. The values for the time at which the spike occurs at the IS, the soma and the end of the model neuron are given in ms and they are marked by vertical arrows.
Mentions: These temporal parameters are displayed in Fig. 6 which demonstrates different spiking behavior when a selected model cell with d = 19.08 μm (which is the mean value of all evaluated diameters) is stimulated by electrode E1 with the four different pulse forms. The time courses of membrane potential of this cell are plotted for monophasic and biphasic threshold stimulations.

Bottom Line: Results show that temporal parameters of the spiking pattern are affected by the size of the cell body.Cathodic stimulation was found to induce stronger variations of spikes while also leading to the lowest thresholds and longest latencies.Therefore, anodic stimulation leads to a more uniform excitation profile among SGCs with different cell body size.

View Article: PubMed Central - PubMed

Affiliation: Innsbruck Medical University, Department of Otorhinolaryngology, Laboratory for Inner Ear Biology, Anichstrasse 35, Innsbruck, Austria.

Show MeSH
Related in: MedlinePlus