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Morphometric classification and spatial organization of spiral ganglion neurons in the human cochlea: consequences for single fiber response to electrical stimulation.

Potrusil T, Wenger C, Glueckert R, Schrott-Fischer A, Rattay F - Neuroscience (2012)

Bottom Line: Results show that temporal parameters of the spiking pattern are affected by the size of the cell body.Cathodic stimulation was found to induce stronger variations of spikes while also leading to the lowest thresholds and longest latencies.Therefore, anodic stimulation leads to a more uniform excitation profile among SGCs with different cell body size.

View Article: PubMed Central - PubMed

Affiliation: Innsbruck Medical University, Department of Otorhinolaryngology, Laboratory for Inner Ear Biology, Anichstrasse 35, Innsbruck, Austria.

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Box–Whisker-plot depicts distributions of volumes from reconstructed perikarya and their nuclei. Data illustrates all acquired volumes of specimen 1 (column A, n = 83), specimen 2 (column B, n = 55) and both specimens (column C, n = 138) according to their location within the human cochlea. The upper horizontal row illustrates perikaryal volumes; lower horizontal row represents the corresponding nuclei.
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f0015: Box–Whisker-plot depicts distributions of volumes from reconstructed perikarya and their nuclei. Data illustrates all acquired volumes of specimen 1 (column A, n = 83), specimen 2 (column B, n = 55) and both specimens (column C, n = 138) according to their location within the human cochlea. The upper horizontal row illustrates perikaryal volumes; lower horizontal row represents the corresponding nuclei.

Mentions: A closer look at specimen 1 shows that the perikaryal size of the apical- and basal turn are comparable (Mapical = 4235 μm3, Mbasal′ = 4011 μm3), varying only by 5.2%, with the largest cells located in the apex. The smallest SGCs from this inner ear are identified within the middle turn (M = 3379 μm3) representing a volumetric difference of 20.2% compared to the median apical value. There is no significant difference regarding the perikarya volumes determined in specimen 1 (Fig. 3A).


Morphometric classification and spatial organization of spiral ganglion neurons in the human cochlea: consequences for single fiber response to electrical stimulation.

Potrusil T, Wenger C, Glueckert R, Schrott-Fischer A, Rattay F - Neuroscience (2012)

Box–Whisker-plot depicts distributions of volumes from reconstructed perikarya and their nuclei. Data illustrates all acquired volumes of specimen 1 (column A, n = 83), specimen 2 (column B, n = 55) and both specimens (column C, n = 138) according to their location within the human cochlea. The upper horizontal row illustrates perikaryal volumes; lower horizontal row represents the corresponding nuclei.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3377987&req=5

f0015: Box–Whisker-plot depicts distributions of volumes from reconstructed perikarya and their nuclei. Data illustrates all acquired volumes of specimen 1 (column A, n = 83), specimen 2 (column B, n = 55) and both specimens (column C, n = 138) according to their location within the human cochlea. The upper horizontal row illustrates perikaryal volumes; lower horizontal row represents the corresponding nuclei.
Mentions: A closer look at specimen 1 shows that the perikaryal size of the apical- and basal turn are comparable (Mapical = 4235 μm3, Mbasal′ = 4011 μm3), varying only by 5.2%, with the largest cells located in the apex. The smallest SGCs from this inner ear are identified within the middle turn (M = 3379 μm3) representing a volumetric difference of 20.2% compared to the median apical value. There is no significant difference regarding the perikarya volumes determined in specimen 1 (Fig. 3A).

Bottom Line: Results show that temporal parameters of the spiking pattern are affected by the size of the cell body.Cathodic stimulation was found to induce stronger variations of spikes while also leading to the lowest thresholds and longest latencies.Therefore, anodic stimulation leads to a more uniform excitation profile among SGCs with different cell body size.

View Article: PubMed Central - PubMed

Affiliation: Innsbruck Medical University, Department of Otorhinolaryngology, Laboratory for Inner Ear Biology, Anichstrasse 35, Innsbruck, Austria.

Show MeSH
Related in: MedlinePlus