Morphometric classification and spatial organization of spiral ganglion neurons in the human cochlea: consequences for single fiber response to electrical stimulation.
Bottom Line: Furthermore, we found evidence of a spatial arrangement of perikarya and their accordant nuclei along the cochlea spiral.Cathodic stimulation was found to induce stronger variations of spikes while also leading to the lowest thresholds and longest latencies.Therefore, anodic stimulation leads to a more uniform excitation profile among SGCs with different cell body size.
Affiliation: Innsbruck Medical University, Department of Otorhinolaryngology, Laboratory for Inner Ear Biology, Anichstrasse 35, Innsbruck, Austria.Show MeSH
Mentions: A closer look at specimen 1 shows that the perikaryal size of the apical- and basal turn are comparable (Mapical = 4235 μm3, Mbasal′ = 4011 μm3), varying only by 5.2%, with the largest cells located in the apex. The smallest SGCs from this inner ear are identified within the middle turn (M = 3379 μm3) representing a volumetric difference of 20.2% compared to the median apical value. There is no significant difference regarding the perikarya volumes determined in specimen 1 (Fig. 3A).
Affiliation: Innsbruck Medical University, Department of Otorhinolaryngology, Laboratory for Inner Ear Biology, Anichstrasse 35, Innsbruck, Austria.