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Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression.

Murphy ML, Frodl T - Biol Mood Anxiety Disord (2011)

Bottom Line: Patients with depression showed decreased white matter fractional anisotropy values in the superior longitudinal fasciculus and increased fractional anisotropy values in the fronto-occipital fasciculus compared to controls.Using quartile and jackknife sensitivity analysis, we found that reduced fractional anisotropy in the left superior longitudinal fasciculus was very stable, with increases in the right fronto-occipital fasciculus driven by just one study.In conclusion, our meta-analysis revealed a significant reduction in fractional anisotropy values in the left superior longitudinal fasciculus, which may ultimately play an important role in the pathology of depression.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry and Institute of Neuroscience, School of Medicine, Trinity College Dublin, University of Dublin, College Green, Dublin 2, Ireland. thomas.frodl@tcd.ie.

ABSTRACT
Fractional anisotropy anomalies occurring in the white matter tracts in the brains of depressed patients may reflect microstructural changes underlying the pathophysiology of this disorder. We conducted a meta-analysis of fractional anisotropy abnormalities occurring in major depressive disorder using voxel-based diffusion tensor imaging studies. Using the Embase, PubMed and Google Scholar databases, 89 relevant data sets were identified, of which 7 (including 188 patients with major depressive disorder and 221 healthy controls) met our inclusion criteria. Authors were contacted to retrieve any additional data required. Coordinates were extracted from clusters of significant white matter fractional anisotropy differences between patients and controls. Relevant demographic, clinical and methodological variables were extracted from each study or obtained directly from authors. The meta-analysis was carried out using Signed Differential Mapping. Patients with depression showed decreased white matter fractional anisotropy values in the superior longitudinal fasciculus and increased fractional anisotropy values in the fronto-occipital fasciculus compared to controls. Using quartile and jackknife sensitivity analysis, we found that reduced fractional anisotropy in the left superior longitudinal fasciculus was very stable, with increases in the right fronto-occipital fasciculus driven by just one study. In conclusion, our meta-analysis revealed a significant reduction in fractional anisotropy values in the left superior longitudinal fasciculus, which may ultimately play an important role in the pathology of depression.

No MeSH data available.


Related in: MedlinePlus

Reduced FA correlates with increased severity and duration of illness. (A) Reduced FA values were seen in the areas highlighted in red in association with increased severity of depression. (B) Reduced FA values were seen in the areas highlighted in red in association with increased duration of illness.
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Figure 3: Reduced FA correlates with increased severity and duration of illness. (A) Reduced FA values were seen in the areas highlighted in red in association with increased severity of depression. (B) Reduced FA values were seen in the areas highlighted in red in association with increased duration of illness.

Mentions: Regression analysis showed that depression severity was associated with decreased FA values in the left SLF: Talairach (-38, -38 and 26; five voxels), SDM = -0.396 per one point increase in severity scale (scale of 1 to 3), P = 0.000168 (Figures 3A and Figure 4). It also showed an increase of FA in the right FOF: Talairach (26, -54 and 0; 34 voxels), SDM = -0.344 per one point increase in severity scale (scale of 1 to 3), P = 0.000017. Moreover, decreased FA values were associated with longer duration of illness in the SLF (-40, -36 and 34; 33 voxels), SDM = 0.087, P = 0.0001 (Figure 3B). An interaction analysis showed that researchers in studies including just untreated patients reported significant FA decreases compared to studies with treated patients in the left SLF: Talairach (-38, -38 and 28; 9 voxels), SDM = 0.416, P = 0.00077. Moreover, studies with treated subjects had significantly larger FA in the right FOF compared to studies without treated subjects: Talairach (22, -56 and -6; 84 voxels), SDM = 0.478, P = 0.00018.


Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression.

Murphy ML, Frodl T - Biol Mood Anxiety Disord (2011)

Reduced FA correlates with increased severity and duration of illness. (A) Reduced FA values were seen in the areas highlighted in red in association with increased severity of depression. (B) Reduced FA values were seen in the areas highlighted in red in association with increased duration of illness.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3377129&req=5

Figure 3: Reduced FA correlates with increased severity and duration of illness. (A) Reduced FA values were seen in the areas highlighted in red in association with increased severity of depression. (B) Reduced FA values were seen in the areas highlighted in red in association with increased duration of illness.
Mentions: Regression analysis showed that depression severity was associated with decreased FA values in the left SLF: Talairach (-38, -38 and 26; five voxels), SDM = -0.396 per one point increase in severity scale (scale of 1 to 3), P = 0.000168 (Figures 3A and Figure 4). It also showed an increase of FA in the right FOF: Talairach (26, -54 and 0; 34 voxels), SDM = -0.344 per one point increase in severity scale (scale of 1 to 3), P = 0.000017. Moreover, decreased FA values were associated with longer duration of illness in the SLF (-40, -36 and 34; 33 voxels), SDM = 0.087, P = 0.0001 (Figure 3B). An interaction analysis showed that researchers in studies including just untreated patients reported significant FA decreases compared to studies with treated patients in the left SLF: Talairach (-38, -38 and 28; 9 voxels), SDM = 0.416, P = 0.00077. Moreover, studies with treated subjects had significantly larger FA in the right FOF compared to studies without treated subjects: Talairach (22, -56 and -6; 84 voxels), SDM = 0.478, P = 0.00018.

Bottom Line: Patients with depression showed decreased white matter fractional anisotropy values in the superior longitudinal fasciculus and increased fractional anisotropy values in the fronto-occipital fasciculus compared to controls.Using quartile and jackknife sensitivity analysis, we found that reduced fractional anisotropy in the left superior longitudinal fasciculus was very stable, with increases in the right fronto-occipital fasciculus driven by just one study.In conclusion, our meta-analysis revealed a significant reduction in fractional anisotropy values in the left superior longitudinal fasciculus, which may ultimately play an important role in the pathology of depression.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry and Institute of Neuroscience, School of Medicine, Trinity College Dublin, University of Dublin, College Green, Dublin 2, Ireland. thomas.frodl@tcd.ie.

ABSTRACT
Fractional anisotropy anomalies occurring in the white matter tracts in the brains of depressed patients may reflect microstructural changes underlying the pathophysiology of this disorder. We conducted a meta-analysis of fractional anisotropy abnormalities occurring in major depressive disorder using voxel-based diffusion tensor imaging studies. Using the Embase, PubMed and Google Scholar databases, 89 relevant data sets were identified, of which 7 (including 188 patients with major depressive disorder and 221 healthy controls) met our inclusion criteria. Authors were contacted to retrieve any additional data required. Coordinates were extracted from clusters of significant white matter fractional anisotropy differences between patients and controls. Relevant demographic, clinical and methodological variables were extracted from each study or obtained directly from authors. The meta-analysis was carried out using Signed Differential Mapping. Patients with depression showed decreased white matter fractional anisotropy values in the superior longitudinal fasciculus and increased fractional anisotropy values in the fronto-occipital fasciculus compared to controls. Using quartile and jackknife sensitivity analysis, we found that reduced fractional anisotropy in the left superior longitudinal fasciculus was very stable, with increases in the right fronto-occipital fasciculus driven by just one study. In conclusion, our meta-analysis revealed a significant reduction in fractional anisotropy values in the left superior longitudinal fasciculus, which may ultimately play an important role in the pathology of depression.

No MeSH data available.


Related in: MedlinePlus