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Ovarian dysgerminoma in two sisters.

Aldhafery BF - J Family Community Med (2008)

Bottom Line: Their exact etiology has not been determined.Few reports are found in the review of the literature on the incidence of dysgerminoma and other germ cell tumors in families.Some of these reports focus on the genetic abnormalities associated with germ cell tumor and the responsible gene.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, King Fahd Hospital of the University, Al-Khobar, Saudi Arabia.

ABSTRACT
Although rare, dysgerminomas are important irrespective of incidence because they affect women of reproductive age (i.e., <45 years). Dysgerminomas make up two thirds of all malignant ovarian neoplasms in women younger than 20 years. All dysgerminomas are considered malignant, but only one third of dysgerminomas behave aggressively. Their exact etiology has not been determined. Few reports are found in the review of the literature on the incidence of dysgerminoma and other germ cell tumors in families. Some of these reports focus on the genetic abnormalities associated with germ cell tumor and the responsible gene. Two cases of dysgerminomas diagnosed in two sisters aged 14 and 19 years old are presented here with their radiological studies.

No MeSH data available.


Related in: MedlinePlus

Patient Two. Two sagittally reconstructed CT scan images showing a large mass arising from the pelvis, displacing the urinary bladder and uterus anteriorly and inferiorly. The mass appears isodense to the muscles and contains multiple areas of low densities representing cystic changes.
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Figure 4: Patient Two. Two sagittally reconstructed CT scan images showing a large mass arising from the pelvis, displacing the urinary bladder and uterus anteriorly and inferiorly. The mass appears isodense to the muscles and contains multiple areas of low densities representing cystic changes.

Mentions: Two years later, her sister presented at the age of 19 with lower abdominal mass, mild pain and dysmenorrhea. Physical examination showed a palpable mass in the lower abdomen and pelvis with mild tenderness. The patient was referred to the Radiology Department where ultrasound, computerized tomography (CT) scan (Figures 3 and 4) and MRI were done. The imaging features of the mass were almost the same as in the first patient. The patient was operated on and the mass was found to have arisen from the left ovary with no macroscopic invasion of surrounding structures. A simple left salpingo-oophrectomy was done followed by radiotherapy and chemotherapy. There has been no follow-up till date.


Ovarian dysgerminoma in two sisters.

Aldhafery BF - J Family Community Med (2008)

Patient Two. Two sagittally reconstructed CT scan images showing a large mass arising from the pelvis, displacing the urinary bladder and uterus anteriorly and inferiorly. The mass appears isodense to the muscles and contains multiple areas of low densities representing cystic changes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3377126&req=5

Figure 4: Patient Two. Two sagittally reconstructed CT scan images showing a large mass arising from the pelvis, displacing the urinary bladder and uterus anteriorly and inferiorly. The mass appears isodense to the muscles and contains multiple areas of low densities representing cystic changes.
Mentions: Two years later, her sister presented at the age of 19 with lower abdominal mass, mild pain and dysmenorrhea. Physical examination showed a palpable mass in the lower abdomen and pelvis with mild tenderness. The patient was referred to the Radiology Department where ultrasound, computerized tomography (CT) scan (Figures 3 and 4) and MRI were done. The imaging features of the mass were almost the same as in the first patient. The patient was operated on and the mass was found to have arisen from the left ovary with no macroscopic invasion of surrounding structures. A simple left salpingo-oophrectomy was done followed by radiotherapy and chemotherapy. There has been no follow-up till date.

Bottom Line: Their exact etiology has not been determined.Few reports are found in the review of the literature on the incidence of dysgerminoma and other germ cell tumors in families.Some of these reports focus on the genetic abnormalities associated with germ cell tumor and the responsible gene.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, King Fahd Hospital of the University, Al-Khobar, Saudi Arabia.

ABSTRACT
Although rare, dysgerminomas are important irrespective of incidence because they affect women of reproductive age (i.e., <45 years). Dysgerminomas make up two thirds of all malignant ovarian neoplasms in women younger than 20 years. All dysgerminomas are considered malignant, but only one third of dysgerminomas behave aggressively. Their exact etiology has not been determined. Few reports are found in the review of the literature on the incidence of dysgerminoma and other germ cell tumors in families. Some of these reports focus on the genetic abnormalities associated with germ cell tumor and the responsible gene. Two cases of dysgerminomas diagnosed in two sisters aged 14 and 19 years old are presented here with their radiological studies.

No MeSH data available.


Related in: MedlinePlus