Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition.
Bottom Line: This treatment resulted in accelerated migration of reactive astrocytes to sequester inflammatory cells that spared myelinated fibres and significantly promoted functional recovery.A variety of in vitro and in vivo experiments further suggested that GSK-3 inhibition stimulated astrocyte migration by decreasing adhesive activity via reduced surface expression of β1-integrin.Our results reveal a novel benefit of GSK-3 inhibition for SCI and suggest that the stimulation of astrocyte migration is a feasible therapeutic strategy for traumatic injury in the central nervous system.
Affiliation: Department of Physiology, Keio University School of Medicine, Tokyo, Japan.Show MeSH
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Mentions: An association between compaction of inflammatory cells by migrating reactive astrocytes and a reduction in delayed neuronal damage, such as demyelination, has been previously reported (Herrmann et al, 2008; Okada et al, 2006). Accordingly, while eriochrome cyanine blue staining revealed severe demyelination, as expected, at the lesion level in the control group at 42 DPI, significantly reduced demyelination was observed in the mice treated with Ro3303544 (Fig 6A).
Affiliation: Department of Physiology, Keio University School of Medicine, Tokyo, Japan.