The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
Bottom Line: Consistently, administration of QC-inhibitors in inflammatory models, such as thioglycollate-induced peritonitis reduced monocyte infiltration.Current strategies targeting CCL2 are mainly based on antibodies or spiegelmers.The application of small, orally available inhibitors of glutaminyl cyclases represents an alternative therapeutic strategy to treat CCL2-driven disorders such as atherosclerosis/restenosis and fibrosis.
Affiliation: Probiodrug AG, Halle, Germany.Show MeSH
Related in: MedlinePlus
Mentions: Primary cells isolated from QCâˆ’/âˆ’ mice secreted equal amounts of CCL2(pE1-76) and total-CCL2 into the conditioned medium after LPS-stimulation (Fig 2A). In contrast, a significantly reduced concentration of CCL2(pE1-76) has been observed in conditioned medium of primary cells isolated from isoQCâˆ’/âˆ’ mice after LPS stimulation (Fig 2B).