Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins.
Bottom Line: These PRRs trigger distinct signal transduction pathways that culminate in induction of an array of cytokines and other mediators required for host defense.The tripartite motif (TRIM) family is a diverse family of RING finger domain-containing proteins, which are involved in a variety of cellular functions.Importantly, recent studies have shown that they are also involved in the regulation of innate immune responses through the modulation of PRR signalling pathways.
Affiliation: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Japan. email@example.comShow MeSH
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Mentions: The signalling through TLRs, RLRs, DNA sensors and several NLRs culminates in the activation of the nuclear factor κB (NF-κB) and IFN regulatory factor (IRF) families of transcription factors via distinct signalling pathways (Kawai & Akira, 2009). Recent studies have shown that the activations of these pathways are regulated by multiple molecules, including the tripartite motif (TRIM) family, which is one of the largest families of RING domain-containing E3 ligases that mediate post-translational modifications such as protein ubiquitination (Fig 1).
Affiliation: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Japan. firstname.lastname@example.org