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Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins.

Kawai T, Akira S - EMBO Mol Med (2011)

Bottom Line: These PRRs trigger distinct signal transduction pathways that culminate in induction of an array of cytokines and other mediators required for host defense.The tripartite motif (TRIM) family is a diverse family of RING finger domain-containing proteins, which are involved in a variety of cellular functions.Importantly, recent studies have shown that they are also involved in the regulation of innate immune responses through the modulation of PRR signalling pathways.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Japan. tkawai@biken.osaka-u.ac.jp

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Schematic representation of human TRIM family proteinsThe TRIM family proteins are classified into 11 subgroups (C-I to C-XI) as defined by Short & Cox, 2006, Ozato et al, 2008 and Carthagena et al, 2009. COS, C-terminal subgroup one signature; FN3, fibronectin type 3; PHD, plant homeodomain; FIL, filamin-type Ig; NHL, NCL-1, HT2A and LIN-41; MATH, meprin and TRAF homology; ARF, ADP ribosylation factor-like; TM, transmembrane; UN, unclassified.
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fig01: Schematic representation of human TRIM family proteinsThe TRIM family proteins are classified into 11 subgroups (C-I to C-XI) as defined by Short & Cox, 2006, Ozato et al, 2008 and Carthagena et al, 2009. COS, C-terminal subgroup one signature; FN3, fibronectin type 3; PHD, plant homeodomain; FIL, filamin-type Ig; NHL, NCL-1, HT2A and LIN-41; MATH, meprin and TRAF homology; ARF, ADP ribosylation factor-like; TM, transmembrane; UN, unclassified.

Mentions: The signalling through TLRs, RLRs, DNA sensors and several NLRs culminates in the activation of the nuclear factor κB (NF-κB) and IFN regulatory factor (IRF) families of transcription factors via distinct signalling pathways (Kawai & Akira, 2009). Recent studies have shown that the activations of these pathways are regulated by multiple molecules, including the tripartite motif (TRIM) family, which is one of the largest families of RING domain-containing E3 ligases that mediate post-translational modifications such as protein ubiquitination (Fig 1).


Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins.

Kawai T, Akira S - EMBO Mol Med (2011)

Schematic representation of human TRIM family proteinsThe TRIM family proteins are classified into 11 subgroups (C-I to C-XI) as defined by Short & Cox, 2006, Ozato et al, 2008 and Carthagena et al, 2009. COS, C-terminal subgroup one signature; FN3, fibronectin type 3; PHD, plant homeodomain; FIL, filamin-type Ig; NHL, NCL-1, HT2A and LIN-41; MATH, meprin and TRAF homology; ARF, ADP ribosylation factor-like; TM, transmembrane; UN, unclassified.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3377094&req=5

fig01: Schematic representation of human TRIM family proteinsThe TRIM family proteins are classified into 11 subgroups (C-I to C-XI) as defined by Short & Cox, 2006, Ozato et al, 2008 and Carthagena et al, 2009. COS, C-terminal subgroup one signature; FN3, fibronectin type 3; PHD, plant homeodomain; FIL, filamin-type Ig; NHL, NCL-1, HT2A and LIN-41; MATH, meprin and TRAF homology; ARF, ADP ribosylation factor-like; TM, transmembrane; UN, unclassified.
Mentions: The signalling through TLRs, RLRs, DNA sensors and several NLRs culminates in the activation of the nuclear factor κB (NF-κB) and IFN regulatory factor (IRF) families of transcription factors via distinct signalling pathways (Kawai & Akira, 2009). Recent studies have shown that the activations of these pathways are regulated by multiple molecules, including the tripartite motif (TRIM) family, which is one of the largest families of RING domain-containing E3 ligases that mediate post-translational modifications such as protein ubiquitination (Fig 1).

Bottom Line: These PRRs trigger distinct signal transduction pathways that culminate in induction of an array of cytokines and other mediators required for host defense.The tripartite motif (TRIM) family is a diverse family of RING finger domain-containing proteins, which are involved in a variety of cellular functions.Importantly, recent studies have shown that they are also involved in the regulation of innate immune responses through the modulation of PRR signalling pathways.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Japan. tkawai@biken.osaka-u.ac.jp

Show MeSH
Related in: MedlinePlus