Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid).
Bottom Line: The latter also displayed fewer and less dramatic expression changes than polypoid lesions.This finding, along with TMIGD1 protein expression patterns in tissues and cell lines, suggests that TMIGD1 might be associated with intestinal-cell differentiation.We conclude that molecular dysregulation in slightly elevated, nonpolypoid, precancerous colorectal lesions may be somewhat less severe than that observed in classic adenomatous polyps.
Affiliation: Institute of Molecular Cancer Research, University of Zurich, Switzerland.Show MeSH
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Mentions: TMIGD1 ranked very high on the list of genes whose expression levels varied markedly with tissue type (Fig 2B), lesion size, and histology (Fig. .3; Supporting Information Table 2). The constant representation of this gene in the multivariate analyses reported thus far reflects its progressive downregulation as transformation advances. As shown in Fig 5A, its expression was clearly decreased in nonpolypoid lesions (fold-change; FC vs. normal mucosa: −19), but the downregulation was much more evident in polypoid lesions (FC −66) and even more dramatic in a small series of advanced cancers (FC −125) we recently examined with exon arrays.
Affiliation: Institute of Molecular Cancer Research, University of Zurich, Switzerland.