Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid).
Bottom Line: The latter also displayed fewer and less dramatic expression changes than polypoid lesions.This finding, along with TMIGD1 protein expression patterns in tissues and cell lines, suggests that TMIGD1 might be associated with intestinal-cell differentiation.We conclude that molecular dysregulation in slightly elevated, nonpolypoid, precancerous colorectal lesions may be somewhat less severe than that observed in classic adenomatous polyps.
Affiliation: Institute of Molecular Cancer Research, University of Zurich, Switzerland.Show MeSH
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Mentions: Specific gene expression patterns were also associated with lesion histology, size, and degree of dysplasia (Fig 3). Diameter and degree of dysplasia were significantly associated with distinct expression profile clusters, which confirms our previous observations (Sabates-Bellver et al, 2007) in 32 polypoid lesions analysed with a different microarray platform. However, as shown in Fig 3A, the present analysis also revealed that serrated and adenomatous lesions are clearly distinct at the transcriptome level.
Affiliation: Institute of Molecular Cancer Research, University of Zurich, Switzerland.