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Tumor microenvironment in NSCLC suppresses NK cells function.

Cremer I, Fridman WH, Sautès-Fridman C - Oncoimmunology (2012)

Bottom Line: NK cells, which contribute to tumor immunosurveillance, are present in the microenvironment of Non-Small-Cell Lung Carcinoma.However, they display strongly altered phenotype with decreased expression of NKp30, NKp80, DNAM-1, CD16 and ILT2, and impaired cytotoxic functions.The possible mechanisms leading to these defects are discussed.

View Article: PubMed Central - PubMed

Affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM); Centre de Recherche des Cordeliers; Paris, France ; Université Pierre et Marie Curie; Paris, France.

ABSTRACT
NK cells, which contribute to tumor immunosurveillance, are present in the microenvironment of Non-Small-Cell Lung Carcinoma. However, they display strongly altered phenotype with decreased expression of NKp30, NKp80, DNAM-1, CD16 and ILT2, and impaired cytotoxic functions. The possible mechanisms leading to these defects are discussed.

No MeSH data available.


Related in: MedlinePlus

Figure 1. Possible mechanisms leading to intratumoral NK cell alterations: NK cells infiltrating lung carcinoma display altered expression of NKp30, NKp80, DNAM-1 and CD16 and impaired capacities of CD107 expression and IFNγ secretion. Tumor cells produce soluble molecules such as IDO, PGE2, TGBβ and/or express membrane molecules (NK ligands) that can downregulate or shed receptors at the surface of NK cells. NK cells can also be inhibited by TGFβ produced by regulatory T cells, that are present in the NSCLC tumor microenvironment. In addition, intratumoral NK display impaired IFNγ secretion that can cause inefficient DC maturation.
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Figure 1: Figure 1. Possible mechanisms leading to intratumoral NK cell alterations: NK cells infiltrating lung carcinoma display altered expression of NKp30, NKp80, DNAM-1 and CD16 and impaired capacities of CD107 expression and IFNγ secretion. Tumor cells produce soluble molecules such as IDO, PGE2, TGBβ and/or express membrane molecules (NK ligands) that can downregulate or shed receptors at the surface of NK cells. NK cells can also be inhibited by TGFβ produced by regulatory T cells, that are present in the NSCLC tumor microenvironment. In addition, intratumoral NK display impaired IFNγ secretion that can cause inefficient DC maturation.

Mentions: Increasing numbers of human studies reveal that the phenotype and the functions of NK cells are altered in the tumor microenvironment. We speculate that these alterations can be related to several mechanisms, including downregulation of receptor expression, shedding of the receptors (Fig. 1), or induction of a particular differentiation program of NK cells.


Tumor microenvironment in NSCLC suppresses NK cells function.

Cremer I, Fridman WH, Sautès-Fridman C - Oncoimmunology (2012)

Figure 1. Possible mechanisms leading to intratumoral NK cell alterations: NK cells infiltrating lung carcinoma display altered expression of NKp30, NKp80, DNAM-1 and CD16 and impaired capacities of CD107 expression and IFNγ secretion. Tumor cells produce soluble molecules such as IDO, PGE2, TGBβ and/or express membrane molecules (NK ligands) that can downregulate or shed receptors at the surface of NK cells. NK cells can also be inhibited by TGFβ produced by regulatory T cells, that are present in the NSCLC tumor microenvironment. In addition, intratumoral NK display impaired IFNγ secretion that can cause inefficient DC maturation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3377004&req=5

Figure 1: Figure 1. Possible mechanisms leading to intratumoral NK cell alterations: NK cells infiltrating lung carcinoma display altered expression of NKp30, NKp80, DNAM-1 and CD16 and impaired capacities of CD107 expression and IFNγ secretion. Tumor cells produce soluble molecules such as IDO, PGE2, TGBβ and/or express membrane molecules (NK ligands) that can downregulate or shed receptors at the surface of NK cells. NK cells can also be inhibited by TGFβ produced by regulatory T cells, that are present in the NSCLC tumor microenvironment. In addition, intratumoral NK display impaired IFNγ secretion that can cause inefficient DC maturation.
Mentions: Increasing numbers of human studies reveal that the phenotype and the functions of NK cells are altered in the tumor microenvironment. We speculate that these alterations can be related to several mechanisms, including downregulation of receptor expression, shedding of the receptors (Fig. 1), or induction of a particular differentiation program of NK cells.

Bottom Line: NK cells, which contribute to tumor immunosurveillance, are present in the microenvironment of Non-Small-Cell Lung Carcinoma.However, they display strongly altered phenotype with decreased expression of NKp30, NKp80, DNAM-1, CD16 and ILT2, and impaired cytotoxic functions.The possible mechanisms leading to these defects are discussed.

View Article: PubMed Central - PubMed

Affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM); Centre de Recherche des Cordeliers; Paris, France ; Université Pierre et Marie Curie; Paris, France.

ABSTRACT
NK cells, which contribute to tumor immunosurveillance, are present in the microenvironment of Non-Small-Cell Lung Carcinoma. However, they display strongly altered phenotype with decreased expression of NKp30, NKp80, DNAM-1, CD16 and ILT2, and impaired cytotoxic functions. The possible mechanisms leading to these defects are discussed.

No MeSH data available.


Related in: MedlinePlus