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Serum 25-hydroxyvitamin D and Ethnic Differences in Arterial Stiffness and Endothelial Function.

Alvarez JA, Gower BA, Calhoun DA, Judd SE, Dong Y, Dudenbostel T, Scholl J, Ashraf AP - J Clin Med Res (2012)

Bottom Line: It is not clear if ethnic differences in 25(OH)D mediate differences in vascular function.Results indicated that 25(OH)D was inversely associated with AIx75, supine systolic blood pressure (SBP), central aortic SBP and central aortic diastolic blood pressure (DBP), independent of age, sex, and percent body fat (standardized β= -0.29 to -0.43, P < 0.05 for all).AAs had greater AIx75 (P = 0.04) and PWV (P = 0.07) and lower FMD (P = 0.02) compared to EA after adjusting for age and percent body fat; further adjustment for 25(OH)D reduced the ethnic differences (P = 0.44, 0.53, and 0.20, respectively).

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition Sciences, University of Alabama Birmingham, Birmingham, AL, USA.

ABSTRACT

Background: Vitamin D reportedly influences vascular function, which is worse in African Americans (AAs) relative to European Americans (EAs). It is not clear if ethnic differences in 25(OH)D mediate differences in vascular function. This study examined the relationships of serum 25-hydroxyvitamin D (25(OH)D) with indicators of vascular function among healthy, young AA and EA adults.

Methods: This is a cross sectional study involving 23 AAs and 22 EAs. The main outcomes were augmentation index (AIx75), central aortic pressure, pulse wave velocity (PWV), flow-mediated dilation (FMD), and seated and supine blood pressures.

Results: Results indicated that 25(OH)D was inversely associated with AIx75, supine systolic blood pressure (SBP), central aortic SBP and central aortic diastolic blood pressure (DBP), independent of age, sex, and percent body fat (standardized β= -0.29 to -0.43, P < 0.05 for all). AAs had greater AIx75 (P = 0.04) and PWV (P = 0.07) and lower FMD (P = 0.02) compared to EA after adjusting for age and percent body fat; further adjustment for 25(OH)D reduced the ethnic differences (P = 0.44, 0.53, and 0.20, respectively).

Conclusion: The 25(OH)D was associated with vascular function in healthy adults, and lower 25(OH)D among AAs may contribute to their greater arterial stiffness and reduced endothelial function (Clinical trials.gov NCT01041365, NCT01041547).

No MeSH data available.


Related in: MedlinePlus

Ethnic differences in vascular function a) unadjusted, b) adjusted for age and percent body fat, and c) further adjusted for 25(OH)D.
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Figure 2: Ethnic differences in vascular function a) unadjusted, b) adjusted for age and percent body fat, and c) further adjusted for 25(OH)D.

Mentions: Ethnic differences in AIx75, PWV, and FMD were attenuated after adjustment for age and percent body fat, and they were further attenuated after additional adjustment for 25(OH)D (Fig. 2). There was a 93% difference between the ethnic groups in AIx75 after adjusting for age and percent fat (P = 0.04); further adjustment for 25(OH)D reduced the ethnic difference to 45.1% (P = 0.44). For FMD, there was a 20.3% difference between the ethnic groups after adjusting for age and percent fat (P = 0.07) which was reduced to a 13.8 % difference after additional adjustment for 25(OH)D (P = 0.53). The ethnic difference in PWV was 6.8% (P = 0.02) after adjustment for age and percent fat, and it was reduced to a 2.9% ethnic difference after further adjustment for 25(OH)D (P = 0.20).


Serum 25-hydroxyvitamin D and Ethnic Differences in Arterial Stiffness and Endothelial Function.

Alvarez JA, Gower BA, Calhoun DA, Judd SE, Dong Y, Dudenbostel T, Scholl J, Ashraf AP - J Clin Med Res (2012)

Ethnic differences in vascular function a) unadjusted, b) adjusted for age and percent body fat, and c) further adjusted for 25(OH)D.
© Copyright Policy - open access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3376878&req=5

Figure 2: Ethnic differences in vascular function a) unadjusted, b) adjusted for age and percent body fat, and c) further adjusted for 25(OH)D.
Mentions: Ethnic differences in AIx75, PWV, and FMD were attenuated after adjustment for age and percent body fat, and they were further attenuated after additional adjustment for 25(OH)D (Fig. 2). There was a 93% difference between the ethnic groups in AIx75 after adjusting for age and percent fat (P = 0.04); further adjustment for 25(OH)D reduced the ethnic difference to 45.1% (P = 0.44). For FMD, there was a 20.3% difference between the ethnic groups after adjusting for age and percent fat (P = 0.07) which was reduced to a 13.8 % difference after additional adjustment for 25(OH)D (P = 0.53). The ethnic difference in PWV was 6.8% (P = 0.02) after adjustment for age and percent fat, and it was reduced to a 2.9% ethnic difference after further adjustment for 25(OH)D (P = 0.20).

Bottom Line: It is not clear if ethnic differences in 25(OH)D mediate differences in vascular function.Results indicated that 25(OH)D was inversely associated with AIx75, supine systolic blood pressure (SBP), central aortic SBP and central aortic diastolic blood pressure (DBP), independent of age, sex, and percent body fat (standardized β= -0.29 to -0.43, P < 0.05 for all).AAs had greater AIx75 (P = 0.04) and PWV (P = 0.07) and lower FMD (P = 0.02) compared to EA after adjusting for age and percent body fat; further adjustment for 25(OH)D reduced the ethnic differences (P = 0.44, 0.53, and 0.20, respectively).

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition Sciences, University of Alabama Birmingham, Birmingham, AL, USA.

ABSTRACT

Background: Vitamin D reportedly influences vascular function, which is worse in African Americans (AAs) relative to European Americans (EAs). It is not clear if ethnic differences in 25(OH)D mediate differences in vascular function. This study examined the relationships of serum 25-hydroxyvitamin D (25(OH)D) with indicators of vascular function among healthy, young AA and EA adults.

Methods: This is a cross sectional study involving 23 AAs and 22 EAs. The main outcomes were augmentation index (AIx75), central aortic pressure, pulse wave velocity (PWV), flow-mediated dilation (FMD), and seated and supine blood pressures.

Results: Results indicated that 25(OH)D was inversely associated with AIx75, supine systolic blood pressure (SBP), central aortic SBP and central aortic diastolic blood pressure (DBP), independent of age, sex, and percent body fat (standardized β= -0.29 to -0.43, P < 0.05 for all). AAs had greater AIx75 (P = 0.04) and PWV (P = 0.07) and lower FMD (P = 0.02) compared to EA after adjusting for age and percent body fat; further adjustment for 25(OH)D reduced the ethnic differences (P = 0.44, 0.53, and 0.20, respectively).

Conclusion: The 25(OH)D was associated with vascular function in healthy adults, and lower 25(OH)D among AAs may contribute to their greater arterial stiffness and reduced endothelial function (Clinical trials.gov NCT01041365, NCT01041547).

No MeSH data available.


Related in: MedlinePlus