Limits...
Particle depositions and related hemodynamic parameters in the multiple stenosed right coronary artery.

Bernad SI, Bernad ES, Craina M, Sargan I, Totoran A, Brisan C - J Clin Med Res (2012)

Bottom Line: Energy loss associated with such flow expansion after each constriction will be large and consequently the pressure drop will be higher.Overall pressure drop increased from 1700 Pa (12.75 mmHg) at the end diastole to 11000 Pa (82.5 mmHg) at the peak systole.However at the end of one cardiac cycle a percent of 1.4% (15 from 1063 particles release at the inlet section) remain inside the stenosed RCA.

View Article: PubMed Central - PubMed

Affiliation: Centre for Fundamental and Advanced Research, Romanian Academy - Timisoara Branch, Timisoara, Romania.

ABSTRACT

Background: Blood flow analysis of the human right coronary artery (RCA) has been carried out to investigate the effects of serial stenosis on coronary hemodynamics. A 3-D model of a serial stenosed RCA was reconstructed based on multislice computerized tomography images.

Methods: A velocity waveform in the proximal RCA and a pressure waveform in the distal RCA of a patient with a severe stenosis were acquired with a catheter delivered wire probe and applied as boundary conditions. The numerical analysis examines closely the effect of a multiple serial stenosis on the hemodynamic characteristics such as flow separation, wall shear stress (WSS) and particle depositions.

Results and conclusions: Energy loss associated with such flow expansion after each constriction will be large and consequently the pressure drop will be higher. Overall pressure drop increased from 1700 Pa (12.75 mmHg) at the end diastole to 11000 Pa (82.5 mmHg) at the peak systole. At the peak systole the WSS values reached 110 Pa in the stenosis with 28% diameter reduction and 210 Pa in the stenosis with 54% diameter reduction, which is high enough to damage the endothelial cells. However at the end of one cardiac cycle a percent of 1.4% (15 from 1063 particles release at the inlet section) remain inside the stenosed RCA.

No MeSH data available.


Related in: MedlinePlus

(a) axial pressure drop and (b) wall shear stress distribution along the stenosis during the cardiac cycle for mean flow rate Q = 50 mL/min.
© Copyright Policy - open access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3376876&req=5

Figure 4: (a) axial pressure drop and (b) wall shear stress distribution along the stenosis during the cardiac cycle for mean flow rate Q = 50 mL/min.

Mentions: The evolution of the axial pressure drop along the stream-wise direction and the wall shear stress profile is compared to the experimental data presented by Banerjee et al [26] as shown in Figure 4. It can be seen that the present numerical result is in good correlation to the experimental data obtained by Banerjee et al.


Particle depositions and related hemodynamic parameters in the multiple stenosed right coronary artery.

Bernad SI, Bernad ES, Craina M, Sargan I, Totoran A, Brisan C - J Clin Med Res (2012)

(a) axial pressure drop and (b) wall shear stress distribution along the stenosis during the cardiac cycle for mean flow rate Q = 50 mL/min.
© Copyright Policy - open access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3376876&req=5

Figure 4: (a) axial pressure drop and (b) wall shear stress distribution along the stenosis during the cardiac cycle for mean flow rate Q = 50 mL/min.
Mentions: The evolution of the axial pressure drop along the stream-wise direction and the wall shear stress profile is compared to the experimental data presented by Banerjee et al [26] as shown in Figure 4. It can be seen that the present numerical result is in good correlation to the experimental data obtained by Banerjee et al.

Bottom Line: Energy loss associated with such flow expansion after each constriction will be large and consequently the pressure drop will be higher.Overall pressure drop increased from 1700 Pa (12.75 mmHg) at the end diastole to 11000 Pa (82.5 mmHg) at the peak systole.However at the end of one cardiac cycle a percent of 1.4% (15 from 1063 particles release at the inlet section) remain inside the stenosed RCA.

View Article: PubMed Central - PubMed

Affiliation: Centre for Fundamental and Advanced Research, Romanian Academy - Timisoara Branch, Timisoara, Romania.

ABSTRACT

Background: Blood flow analysis of the human right coronary artery (RCA) has been carried out to investigate the effects of serial stenosis on coronary hemodynamics. A 3-D model of a serial stenosed RCA was reconstructed based on multislice computerized tomography images.

Methods: A velocity waveform in the proximal RCA and a pressure waveform in the distal RCA of a patient with a severe stenosis were acquired with a catheter delivered wire probe and applied as boundary conditions. The numerical analysis examines closely the effect of a multiple serial stenosis on the hemodynamic characteristics such as flow separation, wall shear stress (WSS) and particle depositions.

Results and conclusions: Energy loss associated with such flow expansion after each constriction will be large and consequently the pressure drop will be higher. Overall pressure drop increased from 1700 Pa (12.75 mmHg) at the end diastole to 11000 Pa (82.5 mmHg) at the peak systole. At the peak systole the WSS values reached 110 Pa in the stenosis with 28% diameter reduction and 210 Pa in the stenosis with 54% diameter reduction, which is high enough to damage the endothelial cells. However at the end of one cardiac cycle a percent of 1.4% (15 from 1063 particles release at the inlet section) remain inside the stenosed RCA.

No MeSH data available.


Related in: MedlinePlus