MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
Bottom Line: MicroRNA expression profiling was shown to be associated with tumour development, progression and response to therapy, suggesting their possible use as diagnostic, prognostic and predictive biomarkers.Moreover, based on the increasing number of studies demonstrating that microRNAs can function as potential oncogenes or oncosuppressor genes, with the goal to improve disease response and increase cure rates, miRNA-based anticancer therapies have recently been exploited, either alone or in combination with current targeted therapies.The advantage of using microRNA approaches is based on its ability to concurrently target multiple effectors of pathways involved in cell differentiation, proliferation and survival.
Affiliation: Start Up Unit, Department of Experimental Oncology, Fondazione IRCCS, Istituto Nazionale Tumori, Milano, Italy.Show MeSH
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Mentions: Evidence described up to date provides the experimental bases for the use of microRNAs as both targets and tools in anti-cancer therapy, but there are at least two primary issues to address to translate these fundamental research advances into medical practice: development of engineered animal models to study cancer-associated microRNAs, and improvement of miRNAs/anti-miRs in vivo delivery efficiency (Fig 4).
Affiliation: Start Up Unit, Department of Experimental Oncology, Fondazione IRCCS, Istituto Nazionale Tumori, Milano, Italy.