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Seroprevalence of Schmallenberg virus antibodies among dairy cattle, the Netherlands, winter 2011-2012.

Elbers AR, Loeffen WL, Quak S, de Boer-Luijtze E, van der Spek AN, Bouwstra R, Maas R, Spierenburg MA, de Kluijver EP, van Schaik G, van der Poel WH - Emerging Infect. Dis. (2012)

Bottom Line: Seroprevalence was significantly higher in the central-eastern part of the Netherlands than in the northern and southern regions (p<0.001).In addition, high (70%-100%) within-herd seroprevalence was observed in 2 SBV-infected dairy herds and 2 SBV-infected sheep herds.No significant differences were found in age-specific prevalence of antibodies against SBV, which is an indication that SBV is newly arrived in the country.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, Crisis Organisation and Diagnostics, Central Veterinary Institute, part of Wageningen UR, Lelystad, the Netherlands. armin.elbers@wur.nl

ABSTRACT
Infections with Schmallenberg virus (SBV) are associated with congenital malformations in ruminants. Because reporting of suspected cases only could underestimate the true rate of infection, we conducted a seroprevalence study in the Netherlands to detect past exposure to SBV among dairy cattle. A total of 1,123 serum samples collected from cattle during November 2011-January 2012 were tested for antibodies against SBV by using a virus neutralization test; seroprevalence was 72.5%. Seroprevalence was significantly higher in the central-eastern part of the Netherlands than in the northern and southern regions (p<0.001). In addition, high (70%-100%) within-herd seroprevalence was observed in 2 SBV-infected dairy herds and 2 SBV-infected sheep herds. No significant differences were found in age-specific prevalence of antibodies against SBV, which is an indication that SBV is newly arrived in the country.

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Frequency distribution of titers for serum samples (n = 814) positive for Schmallenberg virus antibodies by virus neutralization test (VNT) in study of Schmallenberg virus seroprevalence, the Netherlands, 2011–2012.
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Figure 3: Frequency distribution of titers for serum samples (n = 814) positive for Schmallenberg virus antibodies by virus neutralization test (VNT) in study of Schmallenberg virus seroprevalence, the Netherlands, 2011–2012.

Mentions: Figure 2 shows the geographic distribution of seropositive dairy herds (>1 cows sampled tested seropositive) and seronegative dairy herds (all cows sampled tested seronegative). These data indicate no association between cattle density and occurrence of seropositive or seronegative herds. Furthermore, the geographic distribution of seropositive and seronegative herds is random, showing no specific clusters of seropositive or seronegative herds. The estimated seroprevalence of antibodies against SBV in dairy cattle in the central-eastern part of the Netherlands (n = 462; seroprevalence 82.7%, 95% CI 78.8%–86.0%) was significantly (p<0.001) higher than the estimated seroprevalence of antibodies against SBV in dairy cattle in the northern (n = 465; seroprevalence 67.1%, 95% CI 62.6%–71.3%) and southern (n = 196; seroprevalence 61.2%, 95% CI 53.9%–68.0%) parts of the country. Figure 3 shows the distribution of VNT antibody titers against SBV of seropositive samples from dairy cattle; 50% of the samples showed a titer >512.


Seroprevalence of Schmallenberg virus antibodies among dairy cattle, the Netherlands, winter 2011-2012.

Elbers AR, Loeffen WL, Quak S, de Boer-Luijtze E, van der Spek AN, Bouwstra R, Maas R, Spierenburg MA, de Kluijver EP, van Schaik G, van der Poel WH - Emerging Infect. Dis. (2012)

Frequency distribution of titers for serum samples (n = 814) positive for Schmallenberg virus antibodies by virus neutralization test (VNT) in study of Schmallenberg virus seroprevalence, the Netherlands, 2011–2012.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3376820&req=5

Figure 3: Frequency distribution of titers for serum samples (n = 814) positive for Schmallenberg virus antibodies by virus neutralization test (VNT) in study of Schmallenberg virus seroprevalence, the Netherlands, 2011–2012.
Mentions: Figure 2 shows the geographic distribution of seropositive dairy herds (>1 cows sampled tested seropositive) and seronegative dairy herds (all cows sampled tested seronegative). These data indicate no association between cattle density and occurrence of seropositive or seronegative herds. Furthermore, the geographic distribution of seropositive and seronegative herds is random, showing no specific clusters of seropositive or seronegative herds. The estimated seroprevalence of antibodies against SBV in dairy cattle in the central-eastern part of the Netherlands (n = 462; seroprevalence 82.7%, 95% CI 78.8%–86.0%) was significantly (p<0.001) higher than the estimated seroprevalence of antibodies against SBV in dairy cattle in the northern (n = 465; seroprevalence 67.1%, 95% CI 62.6%–71.3%) and southern (n = 196; seroprevalence 61.2%, 95% CI 53.9%–68.0%) parts of the country. Figure 3 shows the distribution of VNT antibody titers against SBV of seropositive samples from dairy cattle; 50% of the samples showed a titer >512.

Bottom Line: Seroprevalence was significantly higher in the central-eastern part of the Netherlands than in the northern and southern regions (p<0.001).In addition, high (70%-100%) within-herd seroprevalence was observed in 2 SBV-infected dairy herds and 2 SBV-infected sheep herds.No significant differences were found in age-specific prevalence of antibodies against SBV, which is an indication that SBV is newly arrived in the country.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, Crisis Organisation and Diagnostics, Central Veterinary Institute, part of Wageningen UR, Lelystad, the Netherlands. armin.elbers@wur.nl

ABSTRACT
Infections with Schmallenberg virus (SBV) are associated with congenital malformations in ruminants. Because reporting of suspected cases only could underestimate the true rate of infection, we conducted a seroprevalence study in the Netherlands to detect past exposure to SBV among dairy cattle. A total of 1,123 serum samples collected from cattle during November 2011-January 2012 were tested for antibodies against SBV by using a virus neutralization test; seroprevalence was 72.5%. Seroprevalence was significantly higher in the central-eastern part of the Netherlands than in the northern and southern regions (p<0.001). In addition, high (70%-100%) within-herd seroprevalence was observed in 2 SBV-infected dairy herds and 2 SBV-infected sheep herds. No significant differences were found in age-specific prevalence of antibodies against SBV, which is an indication that SBV is newly arrived in the country.

Show MeSH
Related in: MedlinePlus