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Outbreak-associated Vibrio cholerae genotypes with identical pulsotypes, Malaysia, 2009.

Teh CS, Suhaili Z, Lim KT, Khamaruddin MA, Yahya F, Sajili MH, Yeo CC, Thong KL - Emerging Infect. Dis. (2012)

Bottom Line: A cholera outbreak in Terengganu, Malaysia, in November 2009 was caused by 2 El Tor Vibrio cholerae variants resistant to typical antimicrobial drugs.Evidence of replacement of treatable V. cholerae infection in the region with antimicrobial-resistant strains calls for increased surveillance and prevention measures.

View Article: PubMed Central - PubMed

Affiliation: University of Malaya, Kuala Lumpur, Malaysia.

ABSTRACT
A cholera outbreak in Terengganu, Malaysia, in November 2009 was caused by 2 El Tor Vibrio cholerae variants resistant to typical antimicrobial drugs. Evidence of replacement of treatable V. cholerae infection in the region with antimicrobial-resistant strains calls for increased surveillance and prevention measures.

Show MeSH

Related in: MedlinePlus

Amino acid sequence alignment of the ctxB subunit of representative Vibrio cholerae isolates from the cholera outbreak, Terengganu, Malaysia, 2009. El Tor O1 N16961 (ctxB3) was used as the reference strain in the alignment. Identical amino acid residues are indicated by dots. Two genotypes (1,3) were observed in the outbreak strains.
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Figure 2: Amino acid sequence alignment of the ctxB subunit of representative Vibrio cholerae isolates from the cholera outbreak, Terengganu, Malaysia, 2009. El Tor O1 N16961 (ctxB3) was used as the reference strain in the alignment. Identical amino acid residues are indicated by dots. Two genotypes (1,3) were observed in the outbreak strains.

Mentions: Several ctxB alleles have been identified among O1 V. cholerae strains on the basis of a few point mutations: 1) classical and El Tor, US Gulf Coast (39His, 46Phe, 68Tyr); 2) El Tor, Australia (39His, 46Leu, 68Tyr); and 3) El Tor, seventh pandemic, and El Tor, Latin American epidemic (39Tyr, 46Phe, 68Ile) (10). Of the 37 isolates, 33 were classified as genotype 3 on the basis of multiple sequence alignments of ctxB (10). Similarly, our previous multilocus sequence typing study (2) subtyped isolate 123/08 as an El Tor biotype characterized by the ctxB3 gene (Figure 2). We postulate that this particular clone has reemerged since its isolation in Kuala Lumpur in 2008 and was likely linked to the 2009 Terengganu outbreak.


Outbreak-associated Vibrio cholerae genotypes with identical pulsotypes, Malaysia, 2009.

Teh CS, Suhaili Z, Lim KT, Khamaruddin MA, Yahya F, Sajili MH, Yeo CC, Thong KL - Emerging Infect. Dis. (2012)

Amino acid sequence alignment of the ctxB subunit of representative Vibrio cholerae isolates from the cholera outbreak, Terengganu, Malaysia, 2009. El Tor O1 N16961 (ctxB3) was used as the reference strain in the alignment. Identical amino acid residues are indicated by dots. Two genotypes (1,3) were observed in the outbreak strains.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3376796&req=5

Figure 2: Amino acid sequence alignment of the ctxB subunit of representative Vibrio cholerae isolates from the cholera outbreak, Terengganu, Malaysia, 2009. El Tor O1 N16961 (ctxB3) was used as the reference strain in the alignment. Identical amino acid residues are indicated by dots. Two genotypes (1,3) were observed in the outbreak strains.
Mentions: Several ctxB alleles have been identified among O1 V. cholerae strains on the basis of a few point mutations: 1) classical and El Tor, US Gulf Coast (39His, 46Phe, 68Tyr); 2) El Tor, Australia (39His, 46Leu, 68Tyr); and 3) El Tor, seventh pandemic, and El Tor, Latin American epidemic (39Tyr, 46Phe, 68Ile) (10). Of the 37 isolates, 33 were classified as genotype 3 on the basis of multiple sequence alignments of ctxB (10). Similarly, our previous multilocus sequence typing study (2) subtyped isolate 123/08 as an El Tor biotype characterized by the ctxB3 gene (Figure 2). We postulate that this particular clone has reemerged since its isolation in Kuala Lumpur in 2008 and was likely linked to the 2009 Terengganu outbreak.

Bottom Line: A cholera outbreak in Terengganu, Malaysia, in November 2009 was caused by 2 El Tor Vibrio cholerae variants resistant to typical antimicrobial drugs.Evidence of replacement of treatable V. cholerae infection in the region with antimicrobial-resistant strains calls for increased surveillance and prevention measures.

View Article: PubMed Central - PubMed

Affiliation: University of Malaya, Kuala Lumpur, Malaysia.

ABSTRACT
A cholera outbreak in Terengganu, Malaysia, in November 2009 was caused by 2 El Tor Vibrio cholerae variants resistant to typical antimicrobial drugs. Evidence of replacement of treatable V. cholerae infection in the region with antimicrobial-resistant strains calls for increased surveillance and prevention measures.

Show MeSH
Related in: MedlinePlus