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Effect of zinc on efficacy of iron supplementation in improving iron and zinc status in women.

Nguyen P, Grajeda R, Melgar P, Marcinkevage J, Flores R, Ramakrishnan U, Martorell R - J Nutr Metab (2012)

Bottom Line: Hb cconcentrations were similar by supplement type, but Hb concentrations improved significantly in anemic women at baseline (increase of 21.8 g/L).Mean percentage changes in serum ferritin were significantly higher in daily compared to weekly supplemented groups (86% versus 32%).In conclusion, adding zinc to IFA supplements did not modify efficacy on iron status or improve zinc status, but daily supplementation was more efficacious than weekly in improving iron stores.

View Article: PubMed Central - PubMed

Affiliation: Nutrition and Health Sciences Program, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.

ABSTRACT
Iron and zinc may interact in micronutrient supplements and thereby decrease efficacy. We investigated interactive effects of combined zinc and iron supplementation in a randomized controlled trial conducted in 459 Guatemalan women. Four groups were supplemented for 12 weeks: (1) weekly iron and folic acid (IFA); (2) weekly IFA and 30 mg zinc; (3) daily IFA; (4) daily IFA and 15 mg zinc. Effects were assessed by generalized linear regression. Baseline hemoglobin (Hb) concentration was 137.4 ± 15.5 g/L, 13% were anemic and 54% had zinc deficiency. Hb cconcentrations were similar by supplement type, but Hb concentrations improved significantly in anemic women at baseline (increase of 21.8 g/L). Mean percentage changes in serum ferritin were significantly higher in daily compared to weekly supplemented groups (86% versus 32%). The addition of zinc to IFA supplements had no significant impact on iron or zinc status. In conclusion, adding zinc to IFA supplements did not modify efficacy on iron status or improve zinc status, but daily supplementation was more efficacious than weekly in improving iron stores.

No MeSH data available.


Related in: MedlinePlus

Flow chart describing participation of subjects in the study.
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Related In: Results  -  Collection


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fig1: Flow chart describing participation of subjects in the study.

Mentions: Since willingness to provide a blood sample was a criterion, blood samples were available for all 459 subjects at baseline (Figure 1). Of these, 422 (92%) finished the trial; reasons for loss to followup were similar across groups, but the daily iron/zinc group had a higher dropout rate compared to the other groups (P = 0.02). A total of 369 women or 88% also provided an endline blood sample (i.e., 52 women refused). Analyses were performed based on these 369 subjects (88 in the weekly iron and zinc group, 97 in the weekly iron group, 84 in the daily iron and zinc group, and 100 in the daily iron group) or 80% of those randomized at baseline. Subjects included in the analyses had similar baseline characteristics compared to subjects not included (P > 0.05, results not shown).


Effect of zinc on efficacy of iron supplementation in improving iron and zinc status in women.

Nguyen P, Grajeda R, Melgar P, Marcinkevage J, Flores R, Ramakrishnan U, Martorell R - J Nutr Metab (2012)

Flow chart describing participation of subjects in the study.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3376765&req=5

fig1: Flow chart describing participation of subjects in the study.
Mentions: Since willingness to provide a blood sample was a criterion, blood samples were available for all 459 subjects at baseline (Figure 1). Of these, 422 (92%) finished the trial; reasons for loss to followup were similar across groups, but the daily iron/zinc group had a higher dropout rate compared to the other groups (P = 0.02). A total of 369 women or 88% also provided an endline blood sample (i.e., 52 women refused). Analyses were performed based on these 369 subjects (88 in the weekly iron and zinc group, 97 in the weekly iron group, 84 in the daily iron and zinc group, and 100 in the daily iron group) or 80% of those randomized at baseline. Subjects included in the analyses had similar baseline characteristics compared to subjects not included (P > 0.05, results not shown).

Bottom Line: Hb cconcentrations were similar by supplement type, but Hb concentrations improved significantly in anemic women at baseline (increase of 21.8 g/L).Mean percentage changes in serum ferritin were significantly higher in daily compared to weekly supplemented groups (86% versus 32%).In conclusion, adding zinc to IFA supplements did not modify efficacy on iron status or improve zinc status, but daily supplementation was more efficacious than weekly in improving iron stores.

View Article: PubMed Central - PubMed

Affiliation: Nutrition and Health Sciences Program, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.

ABSTRACT
Iron and zinc may interact in micronutrient supplements and thereby decrease efficacy. We investigated interactive effects of combined zinc and iron supplementation in a randomized controlled trial conducted in 459 Guatemalan women. Four groups were supplemented for 12 weeks: (1) weekly iron and folic acid (IFA); (2) weekly IFA and 30 mg zinc; (3) daily IFA; (4) daily IFA and 15 mg zinc. Effects were assessed by generalized linear regression. Baseline hemoglobin (Hb) concentration was 137.4 ± 15.5 g/L, 13% were anemic and 54% had zinc deficiency. Hb cconcentrations were similar by supplement type, but Hb concentrations improved significantly in anemic women at baseline (increase of 21.8 g/L). Mean percentage changes in serum ferritin were significantly higher in daily compared to weekly supplemented groups (86% versus 32%). The addition of zinc to IFA supplements had no significant impact on iron or zinc status. In conclusion, adding zinc to IFA supplements did not modify efficacy on iron status or improve zinc status, but daily supplementation was more efficacious than weekly in improving iron stores.

No MeSH data available.


Related in: MedlinePlus