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Enhanced emotional reactivity after selective REM sleep deprivation in humans: an fMRI study.

Rosales-Lagarde A, Armony JL, Del Río-Portilla Y, Trejo-Martínez D, Conde R, Corsi-Cabrera M - Front Behav Neurosci (2012)

Bottom Line: Behaviorally, emotional reactivity was enhanced relative to baseline (BL) in the REM deprived group only.In contrast, activity in these areas remained the same level or even increased in the REM-D group, compared to their BL level.Taken together, these results suggest that lack of REM sleep in humans is associated with enhanced emotional reactivity, both at behavioral and neural levels, and thus highlight the specific role of REM sleep in regulating the neural substrates for emotional responsiveness.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Psychology, Laboratory of Sleep, Universidad Nacional Autónoma de México México DF, México.

ABSTRACT
Converging evidence from animal and human studies suggest that rapid eye movement (REM) sleep modulates emotional processing. The aim of the present study was to explore the effects of selective REM sleep deprivation (REM-D) on emotional responses to threatening visual stimuli and their brain correlates using functional magnetic resonance imaging (fMRI). Twenty healthy subjects were randomly assigned to two groups: selective REM-D, by awakening them at each REM sleep onset, or non-rapid eye movement sleep interruptions (NREM-I) as control for potential non-specific effects of awakenings and lack of sleep. In a within-subject design, a visual emotional reactivity task was performed in the scanner before and 24 h after sleep manipulation. Behaviorally, emotional reactivity was enhanced relative to baseline (BL) in the REM deprived group only. In terms of fMRI signal, there was, as expected, an overall decrease in activity in the NREM-I group when subjects performed the task the second time, particularly in regions involved in emotional processing, such as occipital and temporal areas, as well as in the ventrolateral prefrontal cortex, involved in top-down emotion regulation. In contrast, activity in these areas remained the same level or even increased in the REM-D group, compared to their BL level. Taken together, these results suggest that lack of REM sleep in humans is associated with enhanced emotional reactivity, both at behavioral and neural levels, and thus highlight the specific role of REM sleep in regulating the neural substrates for emotional responsiveness.

No MeSH data available.


Related in: MedlinePlus

Statistical map showing the significant activation cluster (–30 –88 8) for the contrast high reactivity trials (HER) minus low reactivity trials (LER) after REM sleep deprivation (REM-D). The map is thresholded at p < 0.001 (uncorrected). See Table 3 for all significant activations. Bar graphs show the corresponding differences in activation between baseline and experimental night for the REM sleep deprivation and non-REM sleep interruption groups. Asterisks above bars and brackets indicate significant difference from zero and between groups, respectively (p < 0.05).
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Figure 6: Statistical map showing the significant activation cluster (–30 –88 8) for the contrast high reactivity trials (HER) minus low reactivity trials (LER) after REM sleep deprivation (REM-D). The map is thresholded at p < 0.001 (uncorrected). See Table 3 for all significant activations. Bar graphs show the corresponding differences in activation between baseline and experimental night for the REM sleep deprivation and non-REM sleep interruption groups. Asterisks above bars and brackets indicate significant difference from zero and between groups, respectively (p < 0.05).

Mentions: In terms of emotional responses, comparison of the high- and low-emotional reactivity trials (HER > LER) before and after sleep manipulation showed that HER trials elicited increased activation in the left middle occipital gyrus (BA19/18) following REM-D. As shown in Figure 6 and Table 3, post-hoc analyses of the parameters estimates revealed that, in contrast, activity in this region decreased significantly after NREM-I. The reverse contrast did not show significant differences. The contrast between HER and LER trials in the NREM-I group did not differ significantly from BL session.


Enhanced emotional reactivity after selective REM sleep deprivation in humans: an fMRI study.

Rosales-Lagarde A, Armony JL, Del Río-Portilla Y, Trejo-Martínez D, Conde R, Corsi-Cabrera M - Front Behav Neurosci (2012)

Statistical map showing the significant activation cluster (–30 –88 8) for the contrast high reactivity trials (HER) minus low reactivity trials (LER) after REM sleep deprivation (REM-D). The map is thresholded at p < 0.001 (uncorrected). See Table 3 for all significant activations. Bar graphs show the corresponding differences in activation between baseline and experimental night for the REM sleep deprivation and non-REM sleep interruption groups. Asterisks above bars and brackets indicate significant difference from zero and between groups, respectively (p < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3376727&req=5

Figure 6: Statistical map showing the significant activation cluster (–30 –88 8) for the contrast high reactivity trials (HER) minus low reactivity trials (LER) after REM sleep deprivation (REM-D). The map is thresholded at p < 0.001 (uncorrected). See Table 3 for all significant activations. Bar graphs show the corresponding differences in activation between baseline and experimental night for the REM sleep deprivation and non-REM sleep interruption groups. Asterisks above bars and brackets indicate significant difference from zero and between groups, respectively (p < 0.05).
Mentions: In terms of emotional responses, comparison of the high- and low-emotional reactivity trials (HER > LER) before and after sleep manipulation showed that HER trials elicited increased activation in the left middle occipital gyrus (BA19/18) following REM-D. As shown in Figure 6 and Table 3, post-hoc analyses of the parameters estimates revealed that, in contrast, activity in this region decreased significantly after NREM-I. The reverse contrast did not show significant differences. The contrast between HER and LER trials in the NREM-I group did not differ significantly from BL session.

Bottom Line: Behaviorally, emotional reactivity was enhanced relative to baseline (BL) in the REM deprived group only.In contrast, activity in these areas remained the same level or even increased in the REM-D group, compared to their BL level.Taken together, these results suggest that lack of REM sleep in humans is associated with enhanced emotional reactivity, both at behavioral and neural levels, and thus highlight the specific role of REM sleep in regulating the neural substrates for emotional responsiveness.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Psychology, Laboratory of Sleep, Universidad Nacional Autónoma de México México DF, México.

ABSTRACT
Converging evidence from animal and human studies suggest that rapid eye movement (REM) sleep modulates emotional processing. The aim of the present study was to explore the effects of selective REM sleep deprivation (REM-D) on emotional responses to threatening visual stimuli and their brain correlates using functional magnetic resonance imaging (fMRI). Twenty healthy subjects were randomly assigned to two groups: selective REM-D, by awakening them at each REM sleep onset, or non-rapid eye movement sleep interruptions (NREM-I) as control for potential non-specific effects of awakenings and lack of sleep. In a within-subject design, a visual emotional reactivity task was performed in the scanner before and 24 h after sleep manipulation. Behaviorally, emotional reactivity was enhanced relative to baseline (BL) in the REM deprived group only. In terms of fMRI signal, there was, as expected, an overall decrease in activity in the NREM-I group when subjects performed the task the second time, particularly in regions involved in emotional processing, such as occipital and temporal areas, as well as in the ventrolateral prefrontal cortex, involved in top-down emotion regulation. In contrast, activity in these areas remained the same level or even increased in the REM-D group, compared to their BL level. Taken together, these results suggest that lack of REM sleep in humans is associated with enhanced emotional reactivity, both at behavioral and neural levels, and thus highlight the specific role of REM sleep in regulating the neural substrates for emotional responsiveness.

No MeSH data available.


Related in: MedlinePlus