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Aging and osteoarthritis: an inevitable encounter?

Hügle T, Geurts J, Nüesch C, Müller-Gerbl M, Valderrabano V - J Aging Res (2012)

Bottom Line: Collagen cross-linking within the bone results in impaired plasticity and increased stiffness.In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint.A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system.

View Article: PubMed Central - PubMed

Affiliation: Osteoarthritis Research Center, Department of Orthopaedic Surgery, University Hospital Basel, Basel University, Spitalstrasse 21, 4031 Basel, Switzerland.

ABSTRACT
Osteoarthritis (OA) is a major health burden of our time. Age is the most prominent risk factor for the development and progression of OA. The mechanistic influence of aging on OA has different facets. On a molecular level, matrix proteins such as collagen or proteoglycans are modified, which alters cartilage function. Collagen cross-linking within the bone results in impaired plasticity and increased stiffness. Synovial or fat tissue, menisci but also ligaments and muscles play an important role in the pathogenesis of OA. In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint. Inflammation in form of cellular infiltration of synovial tissue or subchondral bone and expression of inflammatory cytokines is more and more recognized as trigger of OA. It has been demonstrated that joint movement can exhibit anti-inflammatory mechanisms. Therefore physical activity or physiotherapy in the elderly should be encouraged, also in order to increase the muscle mass. A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system. New treatment strategies, for example with mesenchymal stem cells (MSC) are investigated, despite clear evidence for their efficacy is lacking.

No MeSH data available.


Related in: MedlinePlus

Cytokine expression at rest and during physical activity. OA: osteoarthritis, IL: interleukin, TNF: tumor necrosis factor.
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fig3: Cytokine expression at rest and during physical activity. OA: osteoarthritis, IL: interleukin, TNF: tumor necrosis factor.

Mentions: In animal models, it has been shown that exercise leads to an increased expression of interleukin-10 in the joint [47]. IL-10 is a strong anti-inflammatory mediator and therefore likely implicated in the resolution of mechanically induced inflammation or irritation (Figure 3).


Aging and osteoarthritis: an inevitable encounter?

Hügle T, Geurts J, Nüesch C, Müller-Gerbl M, Valderrabano V - J Aging Res (2012)

Cytokine expression at rest and during physical activity. OA: osteoarthritis, IL: interleukin, TNF: tumor necrosis factor.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3376541&req=5

fig3: Cytokine expression at rest and during physical activity. OA: osteoarthritis, IL: interleukin, TNF: tumor necrosis factor.
Mentions: In animal models, it has been shown that exercise leads to an increased expression of interleukin-10 in the joint [47]. IL-10 is a strong anti-inflammatory mediator and therefore likely implicated in the resolution of mechanically induced inflammation or irritation (Figure 3).

Bottom Line: Collagen cross-linking within the bone results in impaired plasticity and increased stiffness.In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint.A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system.

View Article: PubMed Central - PubMed

Affiliation: Osteoarthritis Research Center, Department of Orthopaedic Surgery, University Hospital Basel, Basel University, Spitalstrasse 21, 4031 Basel, Switzerland.

ABSTRACT
Osteoarthritis (OA) is a major health burden of our time. Age is the most prominent risk factor for the development and progression of OA. The mechanistic influence of aging on OA has different facets. On a molecular level, matrix proteins such as collagen or proteoglycans are modified, which alters cartilage function. Collagen cross-linking within the bone results in impaired plasticity and increased stiffness. Synovial or fat tissue, menisci but also ligaments and muscles play an important role in the pathogenesis of OA. In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint. Inflammation in form of cellular infiltration of synovial tissue or subchondral bone and expression of inflammatory cytokines is more and more recognized as trigger of OA. It has been demonstrated that joint movement can exhibit anti-inflammatory mechanisms. Therefore physical activity or physiotherapy in the elderly should be encouraged, also in order to increase the muscle mass. A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system. New treatment strategies, for example with mesenchymal stem cells (MSC) are investigated, despite clear evidence for their efficacy is lacking.

No MeSH data available.


Related in: MedlinePlus