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Aging and osteoarthritis: an inevitable encounter?

Hügle T, Geurts J, Nüesch C, Müller-Gerbl M, Valderrabano V - J Aging Res (2012)

Bottom Line: Collagen cross-linking within the bone results in impaired plasticity and increased stiffness.In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint.A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system.

View Article: PubMed Central - PubMed

Affiliation: Osteoarthritis Research Center, Department of Orthopaedic Surgery, University Hospital Basel, Basel University, Spitalstrasse 21, 4031 Basel, Switzerland.

ABSTRACT
Osteoarthritis (OA) is a major health burden of our time. Age is the most prominent risk factor for the development and progression of OA. The mechanistic influence of aging on OA has different facets. On a molecular level, matrix proteins such as collagen or proteoglycans are modified, which alters cartilage function. Collagen cross-linking within the bone results in impaired plasticity and increased stiffness. Synovial or fat tissue, menisci but also ligaments and muscles play an important role in the pathogenesis of OA. In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint. Inflammation in form of cellular infiltration of synovial tissue or subchondral bone and expression of inflammatory cytokines is more and more recognized as trigger of OA. It has been demonstrated that joint movement can exhibit anti-inflammatory mechanisms. Therefore physical activity or physiotherapy in the elderly should be encouraged, also in order to increase the muscle mass. A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system. New treatment strategies, for example with mesenchymal stem cells (MSC) are investigated, despite clear evidence for their efficacy is lacking.

No MeSH data available.


Related in: MedlinePlus

Tibial plateau of an elderly patient showing end-stage OA with complete cartilage loss (a). Computed tomography osteoabsorptiometry (CT-OAM) indicates high bone density in red (b).
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fig2: Tibial plateau of an elderly patient showing end-stage OA with complete cartilage loss (a). Computed tomography osteoabsorptiometry (CT-OAM) indicates high bone density in red (b).

Mentions: The microarchitecture of the skeleton, notably the subchondral bone, constantly adapts to mechanical loading. Mechanotransduction processes lead to bone modeling and remodeling. Impaired joint loading patterns trigger high subchondral bone density, probably in order to avoid (micro) fractures and to ensure minimal joint function. Subchondral density can be accurately assessed by computed tomography osteoabsorptiometry (CT-OAM) [34]. Figure 2 shows a tibial plateau of a geriatric patient suffering from end stage knee OA who underwent joint replacement.


Aging and osteoarthritis: an inevitable encounter?

Hügle T, Geurts J, Nüesch C, Müller-Gerbl M, Valderrabano V - J Aging Res (2012)

Tibial plateau of an elderly patient showing end-stage OA with complete cartilage loss (a). Computed tomography osteoabsorptiometry (CT-OAM) indicates high bone density in red (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3376541&req=5

fig2: Tibial plateau of an elderly patient showing end-stage OA with complete cartilage loss (a). Computed tomography osteoabsorptiometry (CT-OAM) indicates high bone density in red (b).
Mentions: The microarchitecture of the skeleton, notably the subchondral bone, constantly adapts to mechanical loading. Mechanotransduction processes lead to bone modeling and remodeling. Impaired joint loading patterns trigger high subchondral bone density, probably in order to avoid (micro) fractures and to ensure minimal joint function. Subchondral density can be accurately assessed by computed tomography osteoabsorptiometry (CT-OAM) [34]. Figure 2 shows a tibial plateau of a geriatric patient suffering from end stage knee OA who underwent joint replacement.

Bottom Line: Collagen cross-linking within the bone results in impaired plasticity and increased stiffness.In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint.A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system.

View Article: PubMed Central - PubMed

Affiliation: Osteoarthritis Research Center, Department of Orthopaedic Surgery, University Hospital Basel, Basel University, Spitalstrasse 21, 4031 Basel, Switzerland.

ABSTRACT
Osteoarthritis (OA) is a major health burden of our time. Age is the most prominent risk factor for the development and progression of OA. The mechanistic influence of aging on OA has different facets. On a molecular level, matrix proteins such as collagen or proteoglycans are modified, which alters cartilage function. Collagen cross-linking within the bone results in impaired plasticity and increased stiffness. Synovial or fat tissue, menisci but also ligaments and muscles play an important role in the pathogenesis of OA. In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint. Inflammation in form of cellular infiltration of synovial tissue or subchondral bone and expression of inflammatory cytokines is more and more recognized as trigger of OA. It has been demonstrated that joint movement can exhibit anti-inflammatory mechanisms. Therefore physical activity or physiotherapy in the elderly should be encouraged, also in order to increase the muscle mass. A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system. New treatment strategies, for example with mesenchymal stem cells (MSC) are investigated, despite clear evidence for their efficacy is lacking.

No MeSH data available.


Related in: MedlinePlus