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Aging and osteoarthritis: an inevitable encounter?

Hügle T, Geurts J, Nüesch C, Müller-Gerbl M, Valderrabano V - J Aging Res (2012)

Bottom Line: Collagen cross-linking within the bone results in impaired plasticity and increased stiffness.In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint.A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system.

View Article: PubMed Central - PubMed

Affiliation: Osteoarthritis Research Center, Department of Orthopaedic Surgery, University Hospital Basel, Basel University, Spitalstrasse 21, 4031 Basel, Switzerland.

ABSTRACT
Osteoarthritis (OA) is a major health burden of our time. Age is the most prominent risk factor for the development and progression of OA. The mechanistic influence of aging on OA has different facets. On a molecular level, matrix proteins such as collagen or proteoglycans are modified, which alters cartilage function. Collagen cross-linking within the bone results in impaired plasticity and increased stiffness. Synovial or fat tissue, menisci but also ligaments and muscles play an important role in the pathogenesis of OA. In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint. Inflammation in form of cellular infiltration of synovial tissue or subchondral bone and expression of inflammatory cytokines is more and more recognized as trigger of OA. It has been demonstrated that joint movement can exhibit anti-inflammatory mechanisms. Therefore physical activity or physiotherapy in the elderly should be encouraged, also in order to increase the muscle mass. A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system. New treatment strategies, for example with mesenchymal stem cells (MSC) are investigated, despite clear evidence for their efficacy is lacking.

No MeSH data available.


Related in: MedlinePlus

Osteoarthritis as a whole joint disease in the elderly.
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Related In: Results  -  Collection


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fig1: Osteoarthritis as a whole joint disease in the elderly.

Mentions: Half of all persons aged over 65 suffer from osteoarthritis (OA) [1]. As a matter of fact, age is the most prominent risk factor for the initiation and progression of OA. The common explanation for this is the cumulative effect of mechanical load over the years, resulting clinically in “wear and tear” and pathologically in cartilage breakdown [2]. Therefore, OA has been regarded as a naturally occurring, irreversible disorder, rather than a specific, potentially treatable disease. During the last decade, however, it became clearer that OA is not a purely mechanical problem. Inflammatory and metabolic processes are substantially involved in the pathogenesis and progression of OA. Not only cartilage, but also subchondral bone, menisci, muscles as well as fat, and synovial tissues play an important role, notably in the early phase of OA (Figure 1). Therefore, OA has been referred to as a “whole joint disease.” Despite a higher complexity, this concept has not only improved our understanding of the disease but also indicates potentially new treatment strategies.


Aging and osteoarthritis: an inevitable encounter?

Hügle T, Geurts J, Nüesch C, Müller-Gerbl M, Valderrabano V - J Aging Res (2012)

Osteoarthritis as a whole joint disease in the elderly.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3376541&req=5

fig1: Osteoarthritis as a whole joint disease in the elderly.
Mentions: Half of all persons aged over 65 suffer from osteoarthritis (OA) [1]. As a matter of fact, age is the most prominent risk factor for the initiation and progression of OA. The common explanation for this is the cumulative effect of mechanical load over the years, resulting clinically in “wear and tear” and pathologically in cartilage breakdown [2]. Therefore, OA has been regarded as a naturally occurring, irreversible disorder, rather than a specific, potentially treatable disease. During the last decade, however, it became clearer that OA is not a purely mechanical problem. Inflammatory and metabolic processes are substantially involved in the pathogenesis and progression of OA. Not only cartilage, but also subchondral bone, menisci, muscles as well as fat, and synovial tissues play an important role, notably in the early phase of OA (Figure 1). Therefore, OA has been referred to as a “whole joint disease.” Despite a higher complexity, this concept has not only improved our understanding of the disease but also indicates potentially new treatment strategies.

Bottom Line: Collagen cross-linking within the bone results in impaired plasticity and increased stiffness.In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint.A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system.

View Article: PubMed Central - PubMed

Affiliation: Osteoarthritis Research Center, Department of Orthopaedic Surgery, University Hospital Basel, Basel University, Spitalstrasse 21, 4031 Basel, Switzerland.

ABSTRACT
Osteoarthritis (OA) is a major health burden of our time. Age is the most prominent risk factor for the development and progression of OA. The mechanistic influence of aging on OA has different facets. On a molecular level, matrix proteins such as collagen or proteoglycans are modified, which alters cartilage function. Collagen cross-linking within the bone results in impaired plasticity and increased stiffness. Synovial or fat tissue, menisci but also ligaments and muscles play an important role in the pathogenesis of OA. In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint. Inflammation in form of cellular infiltration of synovial tissue or subchondral bone and expression of inflammatory cytokines is more and more recognized as trigger of OA. It has been demonstrated that joint movement can exhibit anti-inflammatory mechanisms. Therefore physical activity or physiotherapy in the elderly should be encouraged, also in order to increase the muscle mass. A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system. New treatment strategies, for example with mesenchymal stem cells (MSC) are investigated, despite clear evidence for their efficacy is lacking.

No MeSH data available.


Related in: MedlinePlus