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Photosensitive-polyimide based method for fabricating various neural electrode architectures.

Kato YX, Furukawa S, Samejima K, Hironaka N, Kashino M - Front Neuroeng (2012)

Bottom Line: After characterizing PSPI's properties for micromachining processes, we successfully designed and fabricated various neural electrodes even on a non-flat substrate using only one PSPI as an insulation material and without the time-consuming dry etching processes.In vivo neural recordings using anesthetized rats demonstrated that these electrodes can be used to record neural activities repeatedly without any breakage and mechanical failures, which potentially promises stable recordings for long periods of time.These successes make us believe that this PSPI-based fabrication is a powerful method, permitting flexible design, and easy optimization of electrode architectures for a variety of electrophysiological experimental research with improved neural recording performance.

View Article: PubMed Central - PubMed

Affiliation: Brain Science Institute, Tamagawa University, Machida Tokyo, Japan.

ABSTRACT
An extensive photosensitive-polyimide (PSPI)-based method for designing and fabricating various neural electrode architectures was developed. The method aims to broaden the design flexibility and expand the fabrication capability for neural electrodes to improve the quality of recorded signals and integrate other functions. After characterizing PSPI's properties for micromachining processes, we successfully designed and fabricated various neural electrodes even on a non-flat substrate using only one PSPI as an insulation material and without the time-consuming dry etching processes. The fabricated neural electrodes were an electrocorticogram (ECoG) electrode, a mesh intracortical electrode with a unique lattice-like mesh structure to fixate neural tissue, and a guide cannula electrode with recording microelectrodes placed on the curved surface of a guide cannula as a microdialysis probe. In vivo neural recordings using anesthetized rats demonstrated that these electrodes can be used to record neural activities repeatedly without any breakage and mechanical failures, which potentially promises stable recordings for long periods of time. These successes make us believe that this PSPI-based fabrication is a powerful method, permitting flexible design, and easy optimization of electrode architectures for a variety of electrophysiological experimental research with improved neural recording performance.

No MeSH data available.


Impedance spectroscopy results for the fabricated PSPI-based neural electrodes. The recording microelectrode's impedances were measured in a 0.9% saline solution at room temperature. (A) The average magnitude of recording microelectrode's impedance for the 100 μm diameter of the ECoG electrode and the guide cannula electrode, and the 40 μm diameter of the mesh intracortical electrode, respectively. (B) The average phase of recording microelectrode's impedance.
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Figure 5: Impedance spectroscopy results for the fabricated PSPI-based neural electrodes. The recording microelectrode's impedances were measured in a 0.9% saline solution at room temperature. (A) The average magnitude of recording microelectrode's impedance for the 100 μm diameter of the ECoG electrode and the guide cannula electrode, and the 40 μm diameter of the mesh intracortical electrode, respectively. (B) The average phase of recording microelectrode's impedance.

Mentions: The measured recording microelectrodes' impedances are shown in Figure 5. At 1 kHz, the average impedance ranged from 196.8 ± 27.8 kΩ for the 100 μm diameter ECoG electrode, 211.6 ± 17.6 kΩ for the 100 μm diameter guide cannula electrode, and 777.5 ± 205.7 kΩ for the 40 μm diameter mesh intracortical electrode. Figure 5A shows that the recording microelectrode's impedance tended to decrease with increasing frequency, probably reflecting the frequency effect on the capacitance in the metal-electrolyte interface, if we assume a typical equivalent circuit (Rubehn et al., 2009).


Photosensitive-polyimide based method for fabricating various neural electrode architectures.

Kato YX, Furukawa S, Samejima K, Hironaka N, Kashino M - Front Neuroeng (2012)

Impedance spectroscopy results for the fabricated PSPI-based neural electrodes. The recording microelectrode's impedances were measured in a 0.9% saline solution at room temperature. (A) The average magnitude of recording microelectrode's impedance for the 100 μm diameter of the ECoG electrode and the guide cannula electrode, and the 40 μm diameter of the mesh intracortical electrode, respectively. (B) The average phase of recording microelectrode's impedance.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3376501&req=5

Figure 5: Impedance spectroscopy results for the fabricated PSPI-based neural electrodes. The recording microelectrode's impedances were measured in a 0.9% saline solution at room temperature. (A) The average magnitude of recording microelectrode's impedance for the 100 μm diameter of the ECoG electrode and the guide cannula electrode, and the 40 μm diameter of the mesh intracortical electrode, respectively. (B) The average phase of recording microelectrode's impedance.
Mentions: The measured recording microelectrodes' impedances are shown in Figure 5. At 1 kHz, the average impedance ranged from 196.8 ± 27.8 kΩ for the 100 μm diameter ECoG electrode, 211.6 ± 17.6 kΩ for the 100 μm diameter guide cannula electrode, and 777.5 ± 205.7 kΩ for the 40 μm diameter mesh intracortical electrode. Figure 5A shows that the recording microelectrode's impedance tended to decrease with increasing frequency, probably reflecting the frequency effect on the capacitance in the metal-electrolyte interface, if we assume a typical equivalent circuit (Rubehn et al., 2009).

Bottom Line: After characterizing PSPI's properties for micromachining processes, we successfully designed and fabricated various neural electrodes even on a non-flat substrate using only one PSPI as an insulation material and without the time-consuming dry etching processes.In vivo neural recordings using anesthetized rats demonstrated that these electrodes can be used to record neural activities repeatedly without any breakage and mechanical failures, which potentially promises stable recordings for long periods of time.These successes make us believe that this PSPI-based fabrication is a powerful method, permitting flexible design, and easy optimization of electrode architectures for a variety of electrophysiological experimental research with improved neural recording performance.

View Article: PubMed Central - PubMed

Affiliation: Brain Science Institute, Tamagawa University, Machida Tokyo, Japan.

ABSTRACT
An extensive photosensitive-polyimide (PSPI)-based method for designing and fabricating various neural electrode architectures was developed. The method aims to broaden the design flexibility and expand the fabrication capability for neural electrodes to improve the quality of recorded signals and integrate other functions. After characterizing PSPI's properties for micromachining processes, we successfully designed and fabricated various neural electrodes even on a non-flat substrate using only one PSPI as an insulation material and without the time-consuming dry etching processes. The fabricated neural electrodes were an electrocorticogram (ECoG) electrode, a mesh intracortical electrode with a unique lattice-like mesh structure to fixate neural tissue, and a guide cannula electrode with recording microelectrodes placed on the curved surface of a guide cannula as a microdialysis probe. In vivo neural recordings using anesthetized rats demonstrated that these electrodes can be used to record neural activities repeatedly without any breakage and mechanical failures, which potentially promises stable recordings for long periods of time. These successes make us believe that this PSPI-based fabrication is a powerful method, permitting flexible design, and easy optimization of electrode architectures for a variety of electrophysiological experimental research with improved neural recording performance.

No MeSH data available.