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Different apathy profile in behavioral variant of frontotemporal dementia and Alzheimer's disease: a preliminary investigation.

Quaranta D, Marra C, Rossi C, Gainotti G, Masullo C - Curr Gerontol Geriatr Res (2012)

Bottom Line: At univariate analysis, bvFTD subjects showed lack of initiation (χ(2) = 4.602, p = 0.032), reduced emotional output (χ(2) = 6.493, p = 0.008), and reduced interest toward friends and family members (χ(2) = 4.898, p = 0.027), more frequently than AD subjects.BvFTD displayed higher scores than AD on NPI total score (p = 0.005) and on subscales assessing agitation (p = 0.004), disinhibition (p = 0.007) and sleep disturbances (p = 0.025); conversely, AD subjects were more impaired on memory, constructional abilities, and attention.On multivariate logistic regression, reduced emotional output was highly predictive of bvFTD (OR = 18.266; p = 0.008).

View Article: PubMed Central - PubMed

Affiliation: Istituto di Neurologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

ABSTRACT
Apathy is one of the most common behavioral symptoms of dementia; it is one of the salient features of behavioral variant of frontotemporal dementia (bvFTD) but is also very frequent in Alzheimer's disease. This preliminary investigation was aimed at assessing the type of apathy-related symptoms in a population of bvFTD and AD subjects showing comparable apathy severity. Each patient underwent a comprehensive neuropsychological assessment; behavioral changes were investigated by the neuropsychiatric inventory (NPI), using the NPI-apathy subscale to detect apathetic symptoms. At univariate analysis, bvFTD subjects showed lack of initiation (χ(2) = 4.602, p = 0.032), reduced emotional output (χ(2) = 6.493, p = 0.008), and reduced interest toward friends and family members (χ(2) = 4.898, p = 0.027), more frequently than AD subjects. BvFTD displayed higher scores than AD on NPI total score (p = 0.005) and on subscales assessing agitation (p = 0.004), disinhibition (p = 0.007) and sleep disturbances (p = 0.025); conversely, AD subjects were more impaired on memory, constructional abilities, and attention. On multivariate logistic regression, reduced emotional output was highly predictive of bvFTD (OR = 18.266; p = 0.008). Our preliminary findings support the hypothesis that apathy is a complex phenomenon, whose clinical expression is conditioned by the site of anatomical damage. Furthermore, apathy profile may help in differentiating bvFTD from AD.

No MeSH data available.


Related in: MedlinePlus

patients' selection work-flow. bvFTD: behavioral variant of frontotemporal dementia; AD: Alzheimer's disease.
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fig1: patients' selection work-flow. bvFTD: behavioral variant of frontotemporal dementia; AD: Alzheimer's disease.

Mentions: Forty-two subjects fulfilling clinical diagnostic criteria for behavioral variant of frontotemporal dementia [25] were screened among subjects referring to our Neuropsychology Unit for memory and behavioral disorders. Exclusion criteria were, in addition to those provided by the corresponding diagnostic criteria, the absence of an informed caregiver, unavailability of neuroradiological examination, and/or the assumption of psychotropic drugs within two months prior to the clinical assessment. Following these exclusion criteria, four patients were excluded in consequence of lack of a sufficiently informed caregiver; three subjects were excluded because neuroimaging examinations were not available; finally, seven subjects were assuming psychotropic drugs (typical antipsychotics: 1 subject; atypical antipsychotics: 1 subject; antidepressants: 4 subjects; cholinesterase inhibitors: 1 subject) during the two months prior to our assessment (see Figure 1).


Different apathy profile in behavioral variant of frontotemporal dementia and Alzheimer's disease: a preliminary investigation.

Quaranta D, Marra C, Rossi C, Gainotti G, Masullo C - Curr Gerontol Geriatr Res (2012)

patients' selection work-flow. bvFTD: behavioral variant of frontotemporal dementia; AD: Alzheimer's disease.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3376472&req=5

fig1: patients' selection work-flow. bvFTD: behavioral variant of frontotemporal dementia; AD: Alzheimer's disease.
Mentions: Forty-two subjects fulfilling clinical diagnostic criteria for behavioral variant of frontotemporal dementia [25] were screened among subjects referring to our Neuropsychology Unit for memory and behavioral disorders. Exclusion criteria were, in addition to those provided by the corresponding diagnostic criteria, the absence of an informed caregiver, unavailability of neuroradiological examination, and/or the assumption of psychotropic drugs within two months prior to the clinical assessment. Following these exclusion criteria, four patients were excluded in consequence of lack of a sufficiently informed caregiver; three subjects were excluded because neuroimaging examinations were not available; finally, seven subjects were assuming psychotropic drugs (typical antipsychotics: 1 subject; atypical antipsychotics: 1 subject; antidepressants: 4 subjects; cholinesterase inhibitors: 1 subject) during the two months prior to our assessment (see Figure 1).

Bottom Line: At univariate analysis, bvFTD subjects showed lack of initiation (χ(2) = 4.602, p = 0.032), reduced emotional output (χ(2) = 6.493, p = 0.008), and reduced interest toward friends and family members (χ(2) = 4.898, p = 0.027), more frequently than AD subjects.BvFTD displayed higher scores than AD on NPI total score (p = 0.005) and on subscales assessing agitation (p = 0.004), disinhibition (p = 0.007) and sleep disturbances (p = 0.025); conversely, AD subjects were more impaired on memory, constructional abilities, and attention.On multivariate logistic regression, reduced emotional output was highly predictive of bvFTD (OR = 18.266; p = 0.008).

View Article: PubMed Central - PubMed

Affiliation: Istituto di Neurologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

ABSTRACT
Apathy is one of the most common behavioral symptoms of dementia; it is one of the salient features of behavioral variant of frontotemporal dementia (bvFTD) but is also very frequent in Alzheimer's disease. This preliminary investigation was aimed at assessing the type of apathy-related symptoms in a population of bvFTD and AD subjects showing comparable apathy severity. Each patient underwent a comprehensive neuropsychological assessment; behavioral changes were investigated by the neuropsychiatric inventory (NPI), using the NPI-apathy subscale to detect apathetic symptoms. At univariate analysis, bvFTD subjects showed lack of initiation (χ(2) = 4.602, p = 0.032), reduced emotional output (χ(2) = 6.493, p = 0.008), and reduced interest toward friends and family members (χ(2) = 4.898, p = 0.027), more frequently than AD subjects. BvFTD displayed higher scores than AD on NPI total score (p = 0.005) and on subscales assessing agitation (p = 0.004), disinhibition (p = 0.007) and sleep disturbances (p = 0.025); conversely, AD subjects were more impaired on memory, constructional abilities, and attention. On multivariate logistic regression, reduced emotional output was highly predictive of bvFTD (OR = 18.266; p = 0.008). Our preliminary findings support the hypothesis that apathy is a complex phenomenon, whose clinical expression is conditioned by the site of anatomical damage. Furthermore, apathy profile may help in differentiating bvFTD from AD.

No MeSH data available.


Related in: MedlinePlus