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Gastric metastasis from a primary renal leiomyosarcoma.

Yodonawa S, Ogawa I, Yoshida S, Ito H, Kato A, Kubokawa R, Tokoshima E, Shimoyamada H - Case Rep Gastroenterol (2012)

Bottom Line: A 73-year-old man visited our hospital suffering from general weakness and intermittent tarry stools.Endoscopy revealed two submucosal tumors in the stomach.These tumors were diagnosed histologically as leiomyosarcoma and distal gastrectomy was performed.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Ibaraki Seinan Medical Center Hospital, Sakai, Japan.

ABSTRACT
Primary leiomyosarcoma of the kidney is rare. Here we report a case of metastasis of this tumor to the stomach. A 73-year-old man visited our hospital suffering from general weakness and intermittent tarry stools. He had undergone right nephrectomy for renal leiomyosarcoma 2 years previously. There had been no local recurrence or distant metastasis in the 2-year follow-up period. Endoscopy revealed two submucosal tumors in the stomach. These tumors were diagnosed histologically as leiomyosarcoma and distal gastrectomy was performed. Subsequent histochemical staining confirmed the diagnosis of gastric metastasis from renal leiomyosarcoma. The patient died due to metastases to the liver and bone 9 months after the operation. To the best of our knowledge, this is the first report of gastric metastasis from primary renal leiomyosarcoma.

No MeSH data available.


Related in: MedlinePlus

Histopathological examination of the gastric tumor showed spindle cells with marked pleomorphism by hematoxylin-eosin staining (×200). The number of mitotic figures was 40–50 per 10 high-power fields (a). Histochemical staining of the gastric tumor was positive for SMA (b), negative for CD34 (c) and negative for c-kit (d) by immunohistological staining (×200).
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Figure 3: Histopathological examination of the gastric tumor showed spindle cells with marked pleomorphism by hematoxylin-eosin staining (×200). The number of mitotic figures was 40–50 per 10 high-power fields (a). Histochemical staining of the gastric tumor was positive for SMA (b), negative for CD34 (c) and negative for c-kit (d) by immunohistological staining (×200).

Mentions: Chest X-ray showed no metastases and computed tomography scans of the abdomen showed a gastric mass and several paragastric lymphadenopathies without other distant organ metastases. Therefore, distal gastrectomy was performed under a diagnosis of metastasis of renal leiomyosarcoma or gastrointestinal stromal tumor of the stomach. Subsequent histopathological examination showed spindle cells with marked pleomorphism. The number of mitotic figures was 40–50 per 10 high-power fields (fig. 3a). In histochemical staining, the tumor was positive for SMA (fig. 3b) and negative for c-kit (fig. 3d) and CD34 (fig. 3c), which confirmed the diagnosis of metastatic high-grade leiomyosarcoma with paragastric lymph node metastases. The postoperative course was uneventful, but the patient died due to metastases to lung, liver and bone 9 months after the operation.


Gastric metastasis from a primary renal leiomyosarcoma.

Yodonawa S, Ogawa I, Yoshida S, Ito H, Kato A, Kubokawa R, Tokoshima E, Shimoyamada H - Case Rep Gastroenterol (2012)

Histopathological examination of the gastric tumor showed spindle cells with marked pleomorphism by hematoxylin-eosin staining (×200). The number of mitotic figures was 40–50 per 10 high-power fields (a). Histochemical staining of the gastric tumor was positive for SMA (b), negative for CD34 (c) and negative for c-kit (d) by immunohistological staining (×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3376334&req=5

Figure 3: Histopathological examination of the gastric tumor showed spindle cells with marked pleomorphism by hematoxylin-eosin staining (×200). The number of mitotic figures was 40–50 per 10 high-power fields (a). Histochemical staining of the gastric tumor was positive for SMA (b), negative for CD34 (c) and negative for c-kit (d) by immunohistological staining (×200).
Mentions: Chest X-ray showed no metastases and computed tomography scans of the abdomen showed a gastric mass and several paragastric lymphadenopathies without other distant organ metastases. Therefore, distal gastrectomy was performed under a diagnosis of metastasis of renal leiomyosarcoma or gastrointestinal stromal tumor of the stomach. Subsequent histopathological examination showed spindle cells with marked pleomorphism. The number of mitotic figures was 40–50 per 10 high-power fields (fig. 3a). In histochemical staining, the tumor was positive for SMA (fig. 3b) and negative for c-kit (fig. 3d) and CD34 (fig. 3c), which confirmed the diagnosis of metastatic high-grade leiomyosarcoma with paragastric lymph node metastases. The postoperative course was uneventful, but the patient died due to metastases to lung, liver and bone 9 months after the operation.

Bottom Line: A 73-year-old man visited our hospital suffering from general weakness and intermittent tarry stools.Endoscopy revealed two submucosal tumors in the stomach.These tumors were diagnosed histologically as leiomyosarcoma and distal gastrectomy was performed.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Ibaraki Seinan Medical Center Hospital, Sakai, Japan.

ABSTRACT
Primary leiomyosarcoma of the kidney is rare. Here we report a case of metastasis of this tumor to the stomach. A 73-year-old man visited our hospital suffering from general weakness and intermittent tarry stools. He had undergone right nephrectomy for renal leiomyosarcoma 2 years previously. There had been no local recurrence or distant metastasis in the 2-year follow-up period. Endoscopy revealed two submucosal tumors in the stomach. These tumors were diagnosed histologically as leiomyosarcoma and distal gastrectomy was performed. Subsequent histochemical staining confirmed the diagnosis of gastric metastasis from renal leiomyosarcoma. The patient died due to metastases to the liver and bone 9 months after the operation. To the best of our knowledge, this is the first report of gastric metastasis from primary renal leiomyosarcoma.

No MeSH data available.


Related in: MedlinePlus