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Kaposi's Sarcoma following Chronic Lymphocytic Leukemia: A Rare Entity.

Kose F, Kocer NE, Sumbul AT, Sezer A, Yilkan O - Case Rep Oncol (2012)

Bottom Line: Cutaneous lesions occur in up to 25% of patients.Most commonly seen cutaneous lesions in CLL are those of infectious or hemorrhagic origin.Herein, we report an interesting case of Kaposi's sarcoma which was diagnosed during the course of CLL.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Baskent University Faculty of Medicine, Ankara, Turkey.

ABSTRACT
Cutaneous manifestations can occur in the wide range of internal malignancy. They can occur by metastases or local spread, direct infiltration, or a site of primary malignancy itself. Sometimes these manifestations are related with an underlying malignancy but they do not contain malignant cells as paraneoplastic dermatological syndromes. Chronic lymphocytic leukemia (CLL) is the most common leukemia all over the world. Cutaneous lesions occur in up to 25% of patients. Most commonly seen cutaneous lesions in CLL are those of infectious or hemorrhagic origin. Skin cancer risk was also increased eightfold in CLL when compared with normal population, so cutaneous lesions in CLL can be the first manifestation of secondary skin malignancy. Herein, we report an interesting case of Kaposi's sarcoma which was diagnosed during the course of CLL.

No MeSH data available.


Related in: MedlinePlus

Bluish and indurate lesions at the lower extremity of the patient.
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Figure 1: Bluish and indurate lesions at the lower extremity of the patient.

Mentions: A 64-year-old female case presented with complaints of bluish and indurate lesions all over both lower extremities (fig. 1). She was first evaluated in a dermatology out-patient clinic. After initial evaluation, biopsy was done from the lesions and KS was diagnosed (fig. 2, fig. 3). The case was referred to the Medical Oncology Department. The patient has had a history of CLL since the year of 1999 but she has not needed any active drug treatment since 1999. She did not have any complication such as bacterial infection or hemolytic anemia throughout the disease course. There was no risk factor in her personal history that disposed the patient to AIDS. Her physical examination revealed hepatosplenomegaly and peripheral lymphadenopathy. Her laboratory workup showed marked lymphocytosis with mature lymphocytes. Laboratory panels for hepatitis B, C and HIV were negative. Quantitative immunoglobulin M and A levels were decreased, whereas immunoglobulin G level was normal. Abdominal and thoracic CT scan showed widespread lymphadenopathy with hepatosplenomegaly. Endoscopic and colonoscopic evaluation of the gastrointestinal system revealed normal findings. Although all tests were negative for systemic involvement of KS, KS lesions have an allover pattern in both extremities, so we planned to administer systemic chemotherapy which consisted of anthracycline, vincristine, and bleomycine. After three cycles of systemic chemotherapy, the lesions had completely disappeared and there was no toxicity of chemotherapeutics.


Kaposi's Sarcoma following Chronic Lymphocytic Leukemia: A Rare Entity.

Kose F, Kocer NE, Sumbul AT, Sezer A, Yilkan O - Case Rep Oncol (2012)

Bluish and indurate lesions at the lower extremity of the patient.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3376333&req=5

Figure 1: Bluish and indurate lesions at the lower extremity of the patient.
Mentions: A 64-year-old female case presented with complaints of bluish and indurate lesions all over both lower extremities (fig. 1). She was first evaluated in a dermatology out-patient clinic. After initial evaluation, biopsy was done from the lesions and KS was diagnosed (fig. 2, fig. 3). The case was referred to the Medical Oncology Department. The patient has had a history of CLL since the year of 1999 but she has not needed any active drug treatment since 1999. She did not have any complication such as bacterial infection or hemolytic anemia throughout the disease course. There was no risk factor in her personal history that disposed the patient to AIDS. Her physical examination revealed hepatosplenomegaly and peripheral lymphadenopathy. Her laboratory workup showed marked lymphocytosis with mature lymphocytes. Laboratory panels for hepatitis B, C and HIV were negative. Quantitative immunoglobulin M and A levels were decreased, whereas immunoglobulin G level was normal. Abdominal and thoracic CT scan showed widespread lymphadenopathy with hepatosplenomegaly. Endoscopic and colonoscopic evaluation of the gastrointestinal system revealed normal findings. Although all tests were negative for systemic involvement of KS, KS lesions have an allover pattern in both extremities, so we planned to administer systemic chemotherapy which consisted of anthracycline, vincristine, and bleomycine. After three cycles of systemic chemotherapy, the lesions had completely disappeared and there was no toxicity of chemotherapeutics.

Bottom Line: Cutaneous lesions occur in up to 25% of patients.Most commonly seen cutaneous lesions in CLL are those of infectious or hemorrhagic origin.Herein, we report an interesting case of Kaposi's sarcoma which was diagnosed during the course of CLL.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Baskent University Faculty of Medicine, Ankara, Turkey.

ABSTRACT
Cutaneous manifestations can occur in the wide range of internal malignancy. They can occur by metastases or local spread, direct infiltration, or a site of primary malignancy itself. Sometimes these manifestations are related with an underlying malignancy but they do not contain malignant cells as paraneoplastic dermatological syndromes. Chronic lymphocytic leukemia (CLL) is the most common leukemia all over the world. Cutaneous lesions occur in up to 25% of patients. Most commonly seen cutaneous lesions in CLL are those of infectious or hemorrhagic origin. Skin cancer risk was also increased eightfold in CLL when compared with normal population, so cutaneous lesions in CLL can be the first manifestation of secondary skin malignancy. Herein, we report an interesting case of Kaposi's sarcoma which was diagnosed during the course of CLL.

No MeSH data available.


Related in: MedlinePlus