Limits...
Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's.

Buijsse B, Lee DH, Steffen L, Erickson RR, Luepker RV, Jacobs DR, Holtzman JL - PLoS ONE (2012)

Bottom Line: This inverse correlation was confined to those with HDLc's below the median (P for interaction, 0.006).The OR's for increasing quartiles of GPx3 in this group were 6.08, 5.00, 3.64 and 1.00 (P for trend, 0.002).Individuals with both low HDLc and GPx3 activity are at markedly increased risk for death from CVD.

View Article: PubMed Central - PubMed

Affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America.

ABSTRACT

Background: Since oxidized LDL is thought to initiate atherosclerosis and the serum glutathione peroxidase (GPx3) reduces oxidized lipids, we investigated whether high GPx3 activity reduces cardiovascular disease (CVD) mortality.

Methods: We determined GPx3 in stored samples from the Minnesota Heart Survey of 130 participants who after 5 to 12 years of follow-up had died of CVD and 240 controls. Participants were 26 to 85 years old and predominantly white. In a nested case-control, study we performed logistic regressions to calculate odds ratios (OR) adjusted for age, sex, baseline year, body mass index, smoking, alcohol intake, physical activity, total and HDL cholesterols, systolic blood pressure, serum glucose and gamma glutamyltransferase (GTT) activity. The referent was the quartile with the highest GPx3 activity (quartile 4).

Results: OR's for CVD mortality for increasing quartiles of GPx3 were 2.37, 2.14, 1.83 and 1.00 (P for trend 0.02). This inverse correlation was confined to those with HDLc's below the median (P for interaction, 0.006). The OR's for increasing quartiles of GPx3 in this group were 6.08, 5.00, 3.64 and 1.00 (P for trend, 0.002).

Conclusions: Individuals with both low HDLc and GPx3 activity are at markedly increased risk for death from CVD.

Show MeSH

Related in: MedlinePlus

The Inverse Correlation between the GPx3 Activity by Quartile and the OR for Cardiovascular Disease Mortality in Individuals with High HDLc and Low HDLc.The trend in the odds ratios for CVD mortality versus the GPx3 activity as estimated by model 3 (see Methods) from the lowest quartile of GPx3 activity (quartile 1) to the highest (quartile 4) for individuals with sex specific HDLc at or above the median HDLc (38 mg% for males; 48 mg% for females) and below the sex specific HDLc. The referent is quartile 4. * P<0.05 as compared to the reference.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3376150&req=5

pone-0038901-g001: The Inverse Correlation between the GPx3 Activity by Quartile and the OR for Cardiovascular Disease Mortality in Individuals with High HDLc and Low HDLc.The trend in the odds ratios for CVD mortality versus the GPx3 activity as estimated by model 3 (see Methods) from the lowest quartile of GPx3 activity (quartile 1) to the highest (quartile 4) for individuals with sex specific HDLc at or above the median HDLc (38 mg% for males; 48 mg% for females) and below the sex specific HDLc. The referent is quartile 4. * P<0.05 as compared to the reference.

Mentions: When we examined the joint association of GPx3 activity and HDLc with CVD mortality, we took the highest GPx3 quartile (quartile 4) and the below median HDLc concentration as the single referent. Compared with this referent, the multivariable-adjusted risk for CVD mortality increased as the GPx3 activities decreased (Figure 1). Compared to those in the highest GPx3 quartile, the OR’s for the first, second, and third quartiles in this group were 6.08, 5.00, and 3.64, respectively (P for trend, 0.002). In contrast, in those at or above the median HDLc concentration, the risk for CVD mortality across quartiles of GPx3 was constant and similar to the risk seen in those with low HDLc and high GPx3 activity.


Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's.

Buijsse B, Lee DH, Steffen L, Erickson RR, Luepker RV, Jacobs DR, Holtzman JL - PLoS ONE (2012)

The Inverse Correlation between the GPx3 Activity by Quartile and the OR for Cardiovascular Disease Mortality in Individuals with High HDLc and Low HDLc.The trend in the odds ratios for CVD mortality versus the GPx3 activity as estimated by model 3 (see Methods) from the lowest quartile of GPx3 activity (quartile 1) to the highest (quartile 4) for individuals with sex specific HDLc at or above the median HDLc (38 mg% for males; 48 mg% for females) and below the sex specific HDLc. The referent is quartile 4. * P<0.05 as compared to the reference.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3376150&req=5

pone-0038901-g001: The Inverse Correlation between the GPx3 Activity by Quartile and the OR for Cardiovascular Disease Mortality in Individuals with High HDLc and Low HDLc.The trend in the odds ratios for CVD mortality versus the GPx3 activity as estimated by model 3 (see Methods) from the lowest quartile of GPx3 activity (quartile 1) to the highest (quartile 4) for individuals with sex specific HDLc at or above the median HDLc (38 mg% for males; 48 mg% for females) and below the sex specific HDLc. The referent is quartile 4. * P<0.05 as compared to the reference.
Mentions: When we examined the joint association of GPx3 activity and HDLc with CVD mortality, we took the highest GPx3 quartile (quartile 4) and the below median HDLc concentration as the single referent. Compared with this referent, the multivariable-adjusted risk for CVD mortality increased as the GPx3 activities decreased (Figure 1). Compared to those in the highest GPx3 quartile, the OR’s for the first, second, and third quartiles in this group were 6.08, 5.00, and 3.64, respectively (P for trend, 0.002). In contrast, in those at or above the median HDLc concentration, the risk for CVD mortality across quartiles of GPx3 was constant and similar to the risk seen in those with low HDLc and high GPx3 activity.

Bottom Line: This inverse correlation was confined to those with HDLc's below the median (P for interaction, 0.006).The OR's for increasing quartiles of GPx3 in this group were 6.08, 5.00, 3.64 and 1.00 (P for trend, 0.002).Individuals with both low HDLc and GPx3 activity are at markedly increased risk for death from CVD.

View Article: PubMed Central - PubMed

Affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America.

ABSTRACT

Background: Since oxidized LDL is thought to initiate atherosclerosis and the serum glutathione peroxidase (GPx3) reduces oxidized lipids, we investigated whether high GPx3 activity reduces cardiovascular disease (CVD) mortality.

Methods: We determined GPx3 in stored samples from the Minnesota Heart Survey of 130 participants who after 5 to 12 years of follow-up had died of CVD and 240 controls. Participants were 26 to 85 years old and predominantly white. In a nested case-control, study we performed logistic regressions to calculate odds ratios (OR) adjusted for age, sex, baseline year, body mass index, smoking, alcohol intake, physical activity, total and HDL cholesterols, systolic blood pressure, serum glucose and gamma glutamyltransferase (GTT) activity. The referent was the quartile with the highest GPx3 activity (quartile 4).

Results: OR's for CVD mortality for increasing quartiles of GPx3 were 2.37, 2.14, 1.83 and 1.00 (P for trend 0.02). This inverse correlation was confined to those with HDLc's below the median (P for interaction, 0.006). The OR's for increasing quartiles of GPx3 in this group were 6.08, 5.00, 3.64 and 1.00 (P for trend, 0.002).

Conclusions: Individuals with both low HDLc and GPx3 activity are at markedly increased risk for death from CVD.

Show MeSH
Related in: MedlinePlus