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Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients.

Loulergue P, Bastides F, Baudouin V, Chandenier J, Mariani-Kurkdjian P, Dupont B, Viard JP, Dromer F, Lortholary O - Emerging Infect. Dis. (2007)

Bottom Line: Most of its ecology and pathogenesis remain unknown.H. capsulatum var. capsulatum is an AIDS-defining opportunistic infection in HIV-infected patients who are living in or have traveled to histoplasmosis-endemic areas.We report 3 cases of imported African histoplasmosis diagnosed in France in HIV-infected patients and a literature review on similar cases.

View Article: PubMed Central - PubMed

Affiliation: University Paris V, Paris, France.

ABSTRACT
African histoplasmosis caused by Histoplasma capsulatum var. duboisii is an invasive fungal infection endemic in central and west Africa. Most of its ecology and pathogenesis remain unknown. H. capsulatum var. capsulatum is an AIDS-defining opportunistic infection in HIV-infected patients who are living in or have traveled to histoplasmosis-endemic areas. In contrast, reports concerning African histoplasmosis during HIV infection are rare, although both pathogens coexist in those regions. We report 3 cases of imported African histoplasmosis diagnosed in France in HIV-infected patients and a literature review on similar cases.

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Direct examination of bone marrow smear. Intracytoplasmic Histoplasma capsulatum var. capsulatum.
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Figure 1: Direct examination of bone marrow smear. Intracytoplasmic Histoplasma capsulatum var. capsulatum.

Mentions: In addition to differences in clinical manifestations and epidemiology, the 2 varieties can be easily distinguished on observation of the yeast phases present in infected fresh or fixed tissues, whereas the saprophytic phase is identical. Variety capsulatum presents as small (3-μm) oval yeasts free or inside histocytes or macrophages (Figure 1), whereas yeasts of variety duboisii are large (7–15 μm), globose to ovoid, thick-walled, and typically lemon-shaped with a narrow budding (Figure 2). They are often seen in the cytoplasma of giant cells (1).


Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients.

Loulergue P, Bastides F, Baudouin V, Chandenier J, Mariani-Kurkdjian P, Dupont B, Viard JP, Dromer F, Lortholary O - Emerging Infect. Dis. (2007)

Direct examination of bone marrow smear. Intracytoplasmic Histoplasma capsulatum var. capsulatum.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3375808&req=5

Figure 1: Direct examination of bone marrow smear. Intracytoplasmic Histoplasma capsulatum var. capsulatum.
Mentions: In addition to differences in clinical manifestations and epidemiology, the 2 varieties can be easily distinguished on observation of the yeast phases present in infected fresh or fixed tissues, whereas the saprophytic phase is identical. Variety capsulatum presents as small (3-μm) oval yeasts free or inside histocytes or macrophages (Figure 1), whereas yeasts of variety duboisii are large (7–15 μm), globose to ovoid, thick-walled, and typically lemon-shaped with a narrow budding (Figure 2). They are often seen in the cytoplasma of giant cells (1).

Bottom Line: Most of its ecology and pathogenesis remain unknown.H. capsulatum var. capsulatum is an AIDS-defining opportunistic infection in HIV-infected patients who are living in or have traveled to histoplasmosis-endemic areas.We report 3 cases of imported African histoplasmosis diagnosed in France in HIV-infected patients and a literature review on similar cases.

View Article: PubMed Central - PubMed

Affiliation: University Paris V, Paris, France.

ABSTRACT
African histoplasmosis caused by Histoplasma capsulatum var. duboisii is an invasive fungal infection endemic in central and west Africa. Most of its ecology and pathogenesis remain unknown. H. capsulatum var. capsulatum is an AIDS-defining opportunistic infection in HIV-infected patients who are living in or have traveled to histoplasmosis-endemic areas. In contrast, reports concerning African histoplasmosis during HIV infection are rare, although both pathogens coexist in those regions. We report 3 cases of imported African histoplasmosis diagnosed in France in HIV-infected patients and a literature review on similar cases.

Show MeSH
Related in: MedlinePlus