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Mycobacterium ulcerans in mosquitoes captured during outbreak of Buruli ulcer, southeastern Australia.

Johnson PD, Azuolas J, Lavender CJ, Wishart E, Stinear TP, Hayman JA, Brown L, Jenkin GA, Fyfe JA - Emerging Infect. Dis. (2007)

Bottom Line: BU developed in 48 residents of Point Lonsdale/Queenscliff and 31 visitors from January 2001 through April 2007.We tested 11,504 mosquitoes trapped at Point Lonsdale (predominantly Aedes camptorhynchus).Forty-eight pools (5 species) were positive for insertion sequence IS2404 (maximum likelihood estimate 4.3/1,000), and we confirmed the presence of M. ulcerans in a subset of pools by detection of 3 additional PCR targets.

View Article: PubMed Central - PubMed

Affiliation: Infectious Disease Department, Austin Health, Melbourne, Victoria, Australia. paul.johnson@austin.org.au

ABSTRACT
Buruli ulcer (BU) occurs in >30 countries. The causative organism, Mycobacterium ulcerans, is acquired from the environment, but the exact mode of transmission is unknown. We investigated an outbreak of BU in a small coastal town in southeastern Australia and screened by PCR mosquitoes caught there. All cases of BU were confirmed by culture or PCR. Mosquitoes were trapped in multiple locations during a 26-month period. BU developed in 48 residents of Point Lonsdale/Queenscliff and 31 visitors from January 2001 through April 2007. We tested 11,504 mosquitoes trapped at Point Lonsdale (predominantly Aedes camptorhynchus). Forty-eight pools (5 species) were positive for insertion sequence IS2404 (maximum likelihood estimate 4.3/1,000), and we confirmed the presence of M. ulcerans in a subset of pools by detection of 3 additional PCR targets.

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Related in: MedlinePlus

Epidemic curve of cases of Buruli ulcer linked to Point Lonsdale/Queenscliff,Australia, by resident/visitor status and month of reporting, 2002–2007.
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Figure 4: Epidemic curve of cases of Buruli ulcer linked to Point Lonsdale/Queenscliff,Australia, by resident/visitor status and month of reporting, 2002–2007.

Mentions: M. ulcerans infection was not found in the area before2002. From January 2002 through April 2007, BU developed in 79 persons (48 residents and31 visitors). Initially, all patients were local residents, but in 2004 the outbreakincreased in intensity and began to include visitors as well as residents (Figure 4). All case-patients who could be accuratelylocated either lived in or visited Point Lonsdale and the western edge of Queenscliff, andnone were linked solely to the main township of Queenscliff.


Mycobacterium ulcerans in mosquitoes captured during outbreak of Buruli ulcer, southeastern Australia.

Johnson PD, Azuolas J, Lavender CJ, Wishart E, Stinear TP, Hayman JA, Brown L, Jenkin GA, Fyfe JA - Emerging Infect. Dis. (2007)

Epidemic curve of cases of Buruli ulcer linked to Point Lonsdale/Queenscliff,Australia, by resident/visitor status and month of reporting, 2002–2007.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3375796&req=5

Figure 4: Epidemic curve of cases of Buruli ulcer linked to Point Lonsdale/Queenscliff,Australia, by resident/visitor status and month of reporting, 2002–2007.
Mentions: M. ulcerans infection was not found in the area before2002. From January 2002 through April 2007, BU developed in 79 persons (48 residents and31 visitors). Initially, all patients were local residents, but in 2004 the outbreakincreased in intensity and began to include visitors as well as residents (Figure 4). All case-patients who could be accuratelylocated either lived in or visited Point Lonsdale and the western edge of Queenscliff, andnone were linked solely to the main township of Queenscliff.

Bottom Line: BU developed in 48 residents of Point Lonsdale/Queenscliff and 31 visitors from January 2001 through April 2007.We tested 11,504 mosquitoes trapped at Point Lonsdale (predominantly Aedes camptorhynchus).Forty-eight pools (5 species) were positive for insertion sequence IS2404 (maximum likelihood estimate 4.3/1,000), and we confirmed the presence of M. ulcerans in a subset of pools by detection of 3 additional PCR targets.

View Article: PubMed Central - PubMed

Affiliation: Infectious Disease Department, Austin Health, Melbourne, Victoria, Australia. paul.johnson@austin.org.au

ABSTRACT
Buruli ulcer (BU) occurs in >30 countries. The causative organism, Mycobacterium ulcerans, is acquired from the environment, but the exact mode of transmission is unknown. We investigated an outbreak of BU in a small coastal town in southeastern Australia and screened by PCR mosquitoes caught there. All cases of BU were confirmed by culture or PCR. Mosquitoes were trapped in multiple locations during a 26-month period. BU developed in 48 residents of Point Lonsdale/Queenscliff and 31 visitors from January 2001 through April 2007. We tested 11,504 mosquitoes trapped at Point Lonsdale (predominantly Aedes camptorhynchus). Forty-eight pools (5 species) were positive for insertion sequence IS2404 (maximum likelihood estimate 4.3/1,000), and we confirmed the presence of M. ulcerans in a subset of pools by detection of 3 additional PCR targets.

Show MeSH
Related in: MedlinePlus