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Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005.

Tu PV, Thao NT, Perera D, Huu TK, Tien NT, Thuong TC, How OM, Cardosa MJ, McMinn PC - Emerging Infect. Dis. (2007)

Bottom Line: HEV71 was isolated throughout the year, with a period of higher prevalence in October-November.Phylogenetic analysis of 23 HEV71 isolates showed that during the first half of 2005, viruses belonging to 3 subgenogroups, C1, C4, and a previously undescribed subgenogroup, C5, cocirculated in southern Vietnam.In the second half of the year, viruses belonging to subgenogroup C5 predominated during a period of higher HEV71 activity.

View Article: PubMed Central - PubMed

Affiliation: Pasteur Institute, Ho Chi Minh City, Vietnam.

ABSTRACT
During 2005, 764 children were brought to a large children's hospital in Ho Chi Minh City, Vietnam, with a diagnosis of hand, foot, and mouth disease. All enrolled children had specimens (vesicle fluid, stool, throat swab) collected for enterovirus isolation by cell culture. An enterovirus was isolated from 411 (53.8%) of the specimens: 173 (42.1%) isolates were identified as human enterovirus 71 (HEV71) and 214 (52.1%) as coxsackievirus A16. Of the identified HEV71 infections, 51 (29.5%) were complicated by acute neurologic disease and 3 (1.7%) were fatal. HEV71 was isolated throughout the year, with a period of higher prevalence in October-November. Phylogenetic analysis of 23 HEV71 isolates showed that during the first half of 2005, viruses belonging to 3 subgenogroups, C1, C4, and a previously undescribed subgenogroup, C5, cocirculated in southern Vietnam. In the second half of the year, viruses belonging to subgenogroup C5 predominated during a period of higher HEV71 activity.

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Related in: MedlinePlus

Geographic distribution of hand, foot, and mouth disease cases associated with human enterovirus 71 (A) or coxsackievirus A16 (B) infection, southern Vietnam, 2005.
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Figure 4: Geographic distribution of hand, foot, and mouth disease cases associated with human enterovirus 71 (A) or coxsackievirus A16 (B) infection, southern Vietnam, 2005.

Mentions: Figure 4 depicts the geographic distribution of HFMD cases due to HEV71 (Figure 4, panel A) and CVA16 (Figure 4, panel B) who were brought for treatment to a major children’s hospital in Ho Chi Minh City. Children admitted to this hospital are predominantly drawn from the urban area but were also referred from provinces surrounding Ho Chi Minh City.


Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005.

Tu PV, Thao NT, Perera D, Huu TK, Tien NT, Thuong TC, How OM, Cardosa MJ, McMinn PC - Emerging Infect. Dis. (2007)

Geographic distribution of hand, foot, and mouth disease cases associated with human enterovirus 71 (A) or coxsackievirus A16 (B) infection, southern Vietnam, 2005.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3375788&req=5

Figure 4: Geographic distribution of hand, foot, and mouth disease cases associated with human enterovirus 71 (A) or coxsackievirus A16 (B) infection, southern Vietnam, 2005.
Mentions: Figure 4 depicts the geographic distribution of HFMD cases due to HEV71 (Figure 4, panel A) and CVA16 (Figure 4, panel B) who were brought for treatment to a major children’s hospital in Ho Chi Minh City. Children admitted to this hospital are predominantly drawn from the urban area but were also referred from provinces surrounding Ho Chi Minh City.

Bottom Line: HEV71 was isolated throughout the year, with a period of higher prevalence in October-November.Phylogenetic analysis of 23 HEV71 isolates showed that during the first half of 2005, viruses belonging to 3 subgenogroups, C1, C4, and a previously undescribed subgenogroup, C5, cocirculated in southern Vietnam.In the second half of the year, viruses belonging to subgenogroup C5 predominated during a period of higher HEV71 activity.

View Article: PubMed Central - PubMed

Affiliation: Pasteur Institute, Ho Chi Minh City, Vietnam.

ABSTRACT
During 2005, 764 children were brought to a large children's hospital in Ho Chi Minh City, Vietnam, with a diagnosis of hand, foot, and mouth disease. All enrolled children had specimens (vesicle fluid, stool, throat swab) collected for enterovirus isolation by cell culture. An enterovirus was isolated from 411 (53.8%) of the specimens: 173 (42.1%) isolates were identified as human enterovirus 71 (HEV71) and 214 (52.1%) as coxsackievirus A16. Of the identified HEV71 infections, 51 (29.5%) were complicated by acute neurologic disease and 3 (1.7%) were fatal. HEV71 was isolated throughout the year, with a period of higher prevalence in October-November. Phylogenetic analysis of 23 HEV71 isolates showed that during the first half of 2005, viruses belonging to 3 subgenogroups, C1, C4, and a previously undescribed subgenogroup, C5, cocirculated in southern Vietnam. In the second half of the year, viruses belonging to subgenogroup C5 predominated during a period of higher HEV71 activity.

Show MeSH
Related in: MedlinePlus