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Methamphetamine use and methicillin-resistant Staphylococcus aureus skin infections.

Cohen AL, Shuler C, McAllister S, Fosheim GE, Brown MG, Abercrombie D, Anderson K, McDougal LK, Drenzek C, Arnold K, Jernigan D, Gorwitz R - Emerging Infect. Dis. (2007)

Bottom Line: Of 119 SSTIs identified, 81 (68.1%) were caused by MRSA.MRSA caused most SSTIs in this population.Transmission of MRSA may be occurring among methamphetamine users in this community.

View Article: PubMed Central - PubMed

Affiliation: Respiratory Diseases Brabch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. alcohen1@cdc.gov

ABSTRACT
Methicillin-resistant Staphylococcus aureus (MRSA) infections and methamphetamine use are emerging public health problems. We conducted a case-control investigation to determine risk factors for MRSA skin and soft tissue infections (SSTIs) in residents of a largely rural southeastern community in the United States. Case-patients were persons >12 years old who had culturable SSTIs; controls had no SSTIs. Of 119 SSTIs identified, 81 (68.1%) were caused by MRSA. Methamphetamine use was reported in 9.9% of case-patients and 1.8% of controls. After we adjusted for age, sex, and race, patients with MRSA SSTIs were more likely than controls to have recently used methamphetamine (odds ratio 5.10, 95% confidence interval 1.55-16.79). MRSA caused most SSTIs in this population. Transmission of MRSA may be occurring among methamphetamine users in this community.

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Related in: MedlinePlus

Dendrogram of pulsed-field types for methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) isolated from methamphetamine users.
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Figure 2: Dendrogram of pulsed-field types for methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) isolated from methamphetamine users.

Mentions: We detected genes for PVL in all MRSA isolates and 5 (41.7%) MSSA isolates; however, the MSSA isolate from a methamphetamine user did not carry the PVL locus. All available MRSA isolates from 6 methamphetamine users and 21 nonusers of methamphetamine had type IV SCCmec resistance complex and were PFGE type USA300. Most of the MRSA isolates were a single strain, PFGE type USA300-0114 (4 [66.7%] were methamphetamine users, 15 [71.4%] were non-methamphetamine users) (Figure 2). One third (33.3%) of MRSA isolates from methamphetamine users and one fifth (19.0%) of MRSA isolates from non-methamphetamine users were variants of USA300-0114, such as USA300-0047.


Methamphetamine use and methicillin-resistant Staphylococcus aureus skin infections.

Cohen AL, Shuler C, McAllister S, Fosheim GE, Brown MG, Abercrombie D, Anderson K, McDougal LK, Drenzek C, Arnold K, Jernigan D, Gorwitz R - Emerging Infect. Dis. (2007)

Dendrogram of pulsed-field types for methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) isolated from methamphetamine users.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3375784&req=5

Figure 2: Dendrogram of pulsed-field types for methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) isolated from methamphetamine users.
Mentions: We detected genes for PVL in all MRSA isolates and 5 (41.7%) MSSA isolates; however, the MSSA isolate from a methamphetamine user did not carry the PVL locus. All available MRSA isolates from 6 methamphetamine users and 21 nonusers of methamphetamine had type IV SCCmec resistance complex and were PFGE type USA300. Most of the MRSA isolates were a single strain, PFGE type USA300-0114 (4 [66.7%] were methamphetamine users, 15 [71.4%] were non-methamphetamine users) (Figure 2). One third (33.3%) of MRSA isolates from methamphetamine users and one fifth (19.0%) of MRSA isolates from non-methamphetamine users were variants of USA300-0114, such as USA300-0047.

Bottom Line: Of 119 SSTIs identified, 81 (68.1%) were caused by MRSA.MRSA caused most SSTIs in this population.Transmission of MRSA may be occurring among methamphetamine users in this community.

View Article: PubMed Central - PubMed

Affiliation: Respiratory Diseases Brabch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. alcohen1@cdc.gov

ABSTRACT
Methicillin-resistant Staphylococcus aureus (MRSA) infections and methamphetamine use are emerging public health problems. We conducted a case-control investigation to determine risk factors for MRSA skin and soft tissue infections (SSTIs) in residents of a largely rural southeastern community in the United States. Case-patients were persons >12 years old who had culturable SSTIs; controls had no SSTIs. Of 119 SSTIs identified, 81 (68.1%) were caused by MRSA. Methamphetamine use was reported in 9.9% of case-patients and 1.8% of controls. After we adjusted for age, sex, and race, patients with MRSA SSTIs were more likely than controls to have recently used methamphetamine (odds ratio 5.10, 95% confidence interval 1.55-16.79). MRSA caused most SSTIs in this population. Transmission of MRSA may be occurring among methamphetamine users in this community.

Show MeSH
Related in: MedlinePlus