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Drug-resistant malaria parasites introduced into Madagascar from Comoros Islands.

Ménard D, Randrianarivo-Solofoniaina AE, Ahmed BS, Jahevitra M, Andriantsoanirina V, Rasolofomanana JR, Rabarijaona LP - Emerging Infect. Dis. (2007)

Bottom Line: To determine risk for drug-resistant malaria parasites entering Madagascar from Comoros Islands, we screened travelers.For the 141 Plasmodium falciparum isolates detected by real-time PCR, frequency of mutant alleles of genes associated with resistance to chloroquine and pyrimethamine was high.International-level antimalarial policy and a regional antimalarial forum are needed.

View Article: PubMed Central - PubMed

Affiliation: Institut Pasteur de Madagascar, Antananarivo, Madagascar. dmenard@pasteur.mg

ABSTRACT
To determine risk for drug-resistant malaria parasites entering Madagascar from Comoros Islands, we screened travelers. For the 141 Plasmodium falciparum isolates detected by real-time PCR, frequency of mutant alleles of genes associated with resistance to chloroquine and pyrimethamine was high. International-level antimalarial policy and a regional antimalarial forum are needed.

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Related in: MedlinePlus

Regional map of the Indian Ocean, showing A) location of Comoros Islands and Madagascar; B) Comoros Islands; and C) location of Mahajanga seaport and airport, Madagascar.
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Related In: Results  -  Collection


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Figure 1: Regional map of the Indian Ocean, showing A) location of Comoros Islands and Madagascar; B) Comoros Islands; and C) location of Mahajanga seaport and airport, Madagascar.

Mentions: The study was performed from March to July 2006, in the seaport and the airport of Mahajanga, on the northwest coast of Madagascar (Figure 1). These sites are the main communications crossroads between the Comoros Islands and Madagascar. The study was approved by the National Ethics Committee of the Ministry of Health and Family Planning of Madagascar.


Drug-resistant malaria parasites introduced into Madagascar from Comoros Islands.

Ménard D, Randrianarivo-Solofoniaina AE, Ahmed BS, Jahevitra M, Andriantsoanirina V, Rasolofomanana JR, Rabarijaona LP - Emerging Infect. Dis. (2007)

Regional map of the Indian Ocean, showing A) location of Comoros Islands and Madagascar; B) Comoros Islands; and C) location of Mahajanga seaport and airport, Madagascar.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3375783&req=5

Figure 1: Regional map of the Indian Ocean, showing A) location of Comoros Islands and Madagascar; B) Comoros Islands; and C) location of Mahajanga seaport and airport, Madagascar.
Mentions: The study was performed from March to July 2006, in the seaport and the airport of Mahajanga, on the northwest coast of Madagascar (Figure 1). These sites are the main communications crossroads between the Comoros Islands and Madagascar. The study was approved by the National Ethics Committee of the Ministry of Health and Family Planning of Madagascar.

Bottom Line: To determine risk for drug-resistant malaria parasites entering Madagascar from Comoros Islands, we screened travelers.For the 141 Plasmodium falciparum isolates detected by real-time PCR, frequency of mutant alleles of genes associated with resistance to chloroquine and pyrimethamine was high.International-level antimalarial policy and a regional antimalarial forum are needed.

View Article: PubMed Central - PubMed

Affiliation: Institut Pasteur de Madagascar, Antananarivo, Madagascar. dmenard@pasteur.mg

ABSTRACT
To determine risk for drug-resistant malaria parasites entering Madagascar from Comoros Islands, we screened travelers. For the 141 Plasmodium falciparum isolates detected by real-time PCR, frequency of mutant alleles of genes associated with resistance to chloroquine and pyrimethamine was high. International-level antimalarial policy and a regional antimalarial forum are needed.

Show MeSH
Related in: MedlinePlus