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Non-A hepatitis B virus genotypes in antenatal clinics, United Kingdom.

Dervisevic S, Ijaz S, Chaudry S, Tedder RS - Emerging Infect. Dis. (2007)

Bottom Line: Serum samples from 114 HBV-infected women were analyzed.Preponderance of genotypes other than A among antenatal mothers in the United Kingdom reflects increasing globalization and trends in immigration.HBeAg serostatus is no longer sufficiently accurate for inferring potential infectivity of pregnant HBV carriers.

View Article: PubMed Central - PubMed

Affiliation: Department of Virology, University College London Hospitals National Health Service Foundation Trust, London, United Kingdom. s.dervisevic@ucl.ac.uk

ABSTRACT
In the United Kingdom, the National Screening Programme for identification of hepatitits B virus (HBV) infection in pregnant women uses HBV e antigen (HBeAg) and antibody to HBeAg (anti-HBe) as markers of infectivity to determine use of immunoglobulin for hepatitis B. Serum samples from 114 HBV-infected women were analyzed. Viral loads correlated with HBeAg/anti-HBe status and viral genotypes. Among 95 mothers whose serum contained anti-HBe, viral loads ranged between undetectable and 8.6 x 10(6) IU/mL (median 228 IU/mL). Ten (10.5%) of these mothers had plasma viral loads >10(4) IU/mL; 6 were infected with genotype E and one each with genotypes A, B, C, and D. All viruses had precore stop codon or basal core promoter mutations. Preponderance of genotypes other than A among antenatal mothers in the United Kingdom reflects increasing globalization and trends in immigration. HBeAg serostatus is no longer sufficiently accurate for inferring potential infectivity of pregnant HBV carriers.

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Related in: MedlinePlus

Box and whisker plots of hepatitis B virus (HBV) load in 3 groups of mothers whose serum contained hepatitis B virus e antigen (HBeAg), antibody to hepatitis B virus e antigen (anti-HBe), or neither of these markers (e Neg). Boxes are middle quartiles, horizontal lines are medians, whiskers are ranges, and dots represent 10 anti-HBe–seropositive mothers whose serum contained >104 IU/mL HBV DNA. Thirty-three anti-HBe–seropositive mothers and 1 mother whose serum did not contain either marker did not have detectable HBV DNA (<50 IU/mL).
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Figure 1: Box and whisker plots of hepatitis B virus (HBV) load in 3 groups of mothers whose serum contained hepatitis B virus e antigen (HBeAg), antibody to hepatitis B virus e antigen (anti-HBe), or neither of these markers (e Neg). Boxes are middle quartiles, horizontal lines are medians, whiskers are ranges, and dots represent 10 anti-HBe–seropositive mothers whose serum contained >104 IU/mL HBV DNA. Thirty-three anti-HBe–seropositive mothers and 1 mother whose serum did not contain either marker did not have detectable HBV DNA (<50 IU/mL).

Mentions: HBV DNA was detected in 96 (84%) serum samples (Figure). The 13 HBeAg-positive serum samples had viral loads that ranged from 7.8 × 105 to 1 × 108 IU/mL (median 2.2 × 107 IU/mL). In 95 samples positive for anti-HBe, viral loads ranged from undetectable to 8.6 × 106 IU/mL (median 228 IU/mL). In 6 serum samples with neither e markers detected, viral loads ranged from undetectable to 750 IU/mL (median 120 IU/mL). Ten (10.5%) of 95 anti-HBe–positive samples had viral loads >104 IU/mL, ranging up to 8.6 × 106 IU/mL.


Non-A hepatitis B virus genotypes in antenatal clinics, United Kingdom.

Dervisevic S, Ijaz S, Chaudry S, Tedder RS - Emerging Infect. Dis. (2007)

Box and whisker plots of hepatitis B virus (HBV) load in 3 groups of mothers whose serum contained hepatitis B virus e antigen (HBeAg), antibody to hepatitis B virus e antigen (anti-HBe), or neither of these markers (e Neg). Boxes are middle quartiles, horizontal lines are medians, whiskers are ranges, and dots represent 10 anti-HBe–seropositive mothers whose serum contained >104 IU/mL HBV DNA. Thirty-three anti-HBe–seropositive mothers and 1 mother whose serum did not contain either marker did not have detectable HBV DNA (<50 IU/mL).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3375778&req=5

Figure 1: Box and whisker plots of hepatitis B virus (HBV) load in 3 groups of mothers whose serum contained hepatitis B virus e antigen (HBeAg), antibody to hepatitis B virus e antigen (anti-HBe), or neither of these markers (e Neg). Boxes are middle quartiles, horizontal lines are medians, whiskers are ranges, and dots represent 10 anti-HBe–seropositive mothers whose serum contained >104 IU/mL HBV DNA. Thirty-three anti-HBe–seropositive mothers and 1 mother whose serum did not contain either marker did not have detectable HBV DNA (<50 IU/mL).
Mentions: HBV DNA was detected in 96 (84%) serum samples (Figure). The 13 HBeAg-positive serum samples had viral loads that ranged from 7.8 × 105 to 1 × 108 IU/mL (median 2.2 × 107 IU/mL). In 95 samples positive for anti-HBe, viral loads ranged from undetectable to 8.6 × 106 IU/mL (median 228 IU/mL). In 6 serum samples with neither e markers detected, viral loads ranged from undetectable to 750 IU/mL (median 120 IU/mL). Ten (10.5%) of 95 anti-HBe–positive samples had viral loads >104 IU/mL, ranging up to 8.6 × 106 IU/mL.

Bottom Line: Serum samples from 114 HBV-infected women were analyzed.Preponderance of genotypes other than A among antenatal mothers in the United Kingdom reflects increasing globalization and trends in immigration.HBeAg serostatus is no longer sufficiently accurate for inferring potential infectivity of pregnant HBV carriers.

View Article: PubMed Central - PubMed

Affiliation: Department of Virology, University College London Hospitals National Health Service Foundation Trust, London, United Kingdom. s.dervisevic@ucl.ac.uk

ABSTRACT
In the United Kingdom, the National Screening Programme for identification of hepatitits B virus (HBV) infection in pregnant women uses HBV e antigen (HBeAg) and antibody to HBeAg (anti-HBe) as markers of infectivity to determine use of immunoglobulin for hepatitis B. Serum samples from 114 HBV-infected women were analyzed. Viral loads correlated with HBeAg/anti-HBe status and viral genotypes. Among 95 mothers whose serum contained anti-HBe, viral loads ranged between undetectable and 8.6 x 10(6) IU/mL (median 228 IU/mL). Ten (10.5%) of these mothers had plasma viral loads >10(4) IU/mL; 6 were infected with genotype E and one each with genotypes A, B, C, and D. All viruses had precore stop codon or basal core promoter mutations. Preponderance of genotypes other than A among antenatal mothers in the United Kingdom reflects increasing globalization and trends in immigration. HBeAg serostatus is no longer sufficiently accurate for inferring potential infectivity of pregnant HBV carriers.

Show MeSH
Related in: MedlinePlus