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Comparison of health-related quality of life in rheumatoid arthritis, psoriatic arthritis and psoriasis and effects of etanercept treatment.

Strand V, Sharp V, Koenig AS, Park G, Shi Y, Wang B, Zack DJ, Fiorentino D - Ann. Rheum. Dis. (2012)

Bottom Line: Baseline comparisons with age and gender-matched norms and treatment-associated changes in domain scores were quantified using spydergrams and the health utility SF-6D measure.Treatment with etanercept resulted in improvements in PCS and MCS scores as well as individual SF-36 domains across all indications.Treatment with etanercept was associated with improvements in PCS and MCS scores as well as individual domain scores in patients with RA, PsA and psoriasis.

View Article: PubMed Central - PubMed

Affiliation: Division of Immunology/Rheumatology, Stanford University, 306 Ramona Road, Portola Valley, CA 94028, USA. vstrand@stanford.edu

ABSTRACT

Objectives: To compare health-related quality of life (HRQoL) before and after treatment with etanercept in patients with moderate to severe rheumatoid arthritis (RA), psoriatic arthritis (PsA) and psoriasis using spydergram representations.

Methods: Data from randomised, controlled trials of etanercept in patients with RA, PsA and psoriasis were analysed. HRQoL was assessed by the medical outcomes survey short form 36 (SF-36) physical (PCS) and mental (MCS) component summary and domain scores. Baseline comparisons with age and gender-matched norms and treatment-associated changes in domain scores were quantified using spydergrams and the health utility SF-6D measure.

Results: Mean baseline PCS scores were lower than age and gender-matched norms in patients with RA and PsA, but near normative values in patients with psoriasis; MCS scores at baseline were near normal in PsA and psoriasis but low in RA. Treatment with etanercept resulted in improvements in PCS and MCS scores as well as individual SF-36 domains across all indications. Mean baseline SF-6D scores were higher in psoriasis than in RA or PsA; clinically meaningful improvements in SF-6D were observed in all three patient populations following treatment with etanercept.

Conclusions: Patients with RA, PsA and psoriasis demonstrated unique HRQoL profiles at baseline. Treatment with etanercept was associated with improvements in PCS and MCS scores as well as individual domain scores in patients with RA, PsA and psoriasis.

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Related in: MedlinePlus

Short form 36 (SF-36) spydergrams for patients with psoriatic arthritis. Mean SF-36 scores at baseline and weeks 4, 12 and 24, and age and gender-matched norms are shown for patients receiving (A) placebo or (B) etanercept. (C) Mean SF-36 scores at baseline and week 24 for patients treated with placebo or etanercept are compared. Mean SF-36 scores for age and gender-matched norms are also shown. BP, bodily pain; ETN, etanercept; GH, general health; MH, mental health; PF, physical function; PL, placebo; RE, role emotional; RP, role physical; SF, social functioning; VT, vitality.
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Figure 2: Short form 36 (SF-36) spydergrams for patients with psoriatic arthritis. Mean SF-36 scores at baseline and weeks 4, 12 and 24, and age and gender-matched norms are shown for patients receiving (A) placebo or (B) etanercept. (C) Mean SF-36 scores at baseline and week 24 for patients treated with placebo or etanercept are compared. Mean SF-36 scores for age and gender-matched norms are also shown. BP, bodily pain; ETN, etanercept; GH, general health; MH, mental health; PF, physical function; PL, placebo; RE, role emotional; RP, role physical; SF, social functioning; VT, vitality.

Mentions: Large reductions were reported in all domains of the SF-36 at baseline in patients with PsA (figure 2A,B); the most severely impacted domains were RP, BP and VT. After 24 weeks of treatment, statistically significant and clinically meaningful improvements in all domains were reported by patients receiving etanercept (p<0.0001 for all domains except RE, p=0.004); the greatest improvements were in the physical domains RP (25.8 points), BP (23.4 points) and PF (20.4 points). Patients receiving placebo reported statistically significant and clinically meaningful improvements in PF (4.2 points), BP (5.8 points), VT (4.5 points) and SF (5.6 points). Etanercept therapy was associated with greater improvements across all domains compared with placebo (figure 2C).


Comparison of health-related quality of life in rheumatoid arthritis, psoriatic arthritis and psoriasis and effects of etanercept treatment.

Strand V, Sharp V, Koenig AS, Park G, Shi Y, Wang B, Zack DJ, Fiorentino D - Ann. Rheum. Dis. (2012)

Short form 36 (SF-36) spydergrams for patients with psoriatic arthritis. Mean SF-36 scores at baseline and weeks 4, 12 and 24, and age and gender-matched norms are shown for patients receiving (A) placebo or (B) etanercept. (C) Mean SF-36 scores at baseline and week 24 for patients treated with placebo or etanercept are compared. Mean SF-36 scores for age and gender-matched norms are also shown. BP, bodily pain; ETN, etanercept; GH, general health; MH, mental health; PF, physical function; PL, placebo; RE, role emotional; RP, role physical; SF, social functioning; VT, vitality.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3375587&req=5

Figure 2: Short form 36 (SF-36) spydergrams for patients with psoriatic arthritis. Mean SF-36 scores at baseline and weeks 4, 12 and 24, and age and gender-matched norms are shown for patients receiving (A) placebo or (B) etanercept. (C) Mean SF-36 scores at baseline and week 24 for patients treated with placebo or etanercept are compared. Mean SF-36 scores for age and gender-matched norms are also shown. BP, bodily pain; ETN, etanercept; GH, general health; MH, mental health; PF, physical function; PL, placebo; RE, role emotional; RP, role physical; SF, social functioning; VT, vitality.
Mentions: Large reductions were reported in all domains of the SF-36 at baseline in patients with PsA (figure 2A,B); the most severely impacted domains were RP, BP and VT. After 24 weeks of treatment, statistically significant and clinically meaningful improvements in all domains were reported by patients receiving etanercept (p<0.0001 for all domains except RE, p=0.004); the greatest improvements were in the physical domains RP (25.8 points), BP (23.4 points) and PF (20.4 points). Patients receiving placebo reported statistically significant and clinically meaningful improvements in PF (4.2 points), BP (5.8 points), VT (4.5 points) and SF (5.6 points). Etanercept therapy was associated with greater improvements across all domains compared with placebo (figure 2C).

Bottom Line: Baseline comparisons with age and gender-matched norms and treatment-associated changes in domain scores were quantified using spydergrams and the health utility SF-6D measure.Treatment with etanercept resulted in improvements in PCS and MCS scores as well as individual SF-36 domains across all indications.Treatment with etanercept was associated with improvements in PCS and MCS scores as well as individual domain scores in patients with RA, PsA and psoriasis.

View Article: PubMed Central - PubMed

Affiliation: Division of Immunology/Rheumatology, Stanford University, 306 Ramona Road, Portola Valley, CA 94028, USA. vstrand@stanford.edu

ABSTRACT

Objectives: To compare health-related quality of life (HRQoL) before and after treatment with etanercept in patients with moderate to severe rheumatoid arthritis (RA), psoriatic arthritis (PsA) and psoriasis using spydergram representations.

Methods: Data from randomised, controlled trials of etanercept in patients with RA, PsA and psoriasis were analysed. HRQoL was assessed by the medical outcomes survey short form 36 (SF-36) physical (PCS) and mental (MCS) component summary and domain scores. Baseline comparisons with age and gender-matched norms and treatment-associated changes in domain scores were quantified using spydergrams and the health utility SF-6D measure.

Results: Mean baseline PCS scores were lower than age and gender-matched norms in patients with RA and PsA, but near normative values in patients with psoriasis; MCS scores at baseline were near normal in PsA and psoriasis but low in RA. Treatment with etanercept resulted in improvements in PCS and MCS scores as well as individual SF-36 domains across all indications. Mean baseline SF-6D scores were higher in psoriasis than in RA or PsA; clinically meaningful improvements in SF-6D were observed in all three patient populations following treatment with etanercept.

Conclusions: Patients with RA, PsA and psoriasis demonstrated unique HRQoL profiles at baseline. Treatment with etanercept was associated with improvements in PCS and MCS scores as well as individual domain scores in patients with RA, PsA and psoriasis.

Show MeSH
Related in: MedlinePlus