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Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results.

Luigi P, Chiara FM, Laura Z, Cristiano M, Giuseppina C, Luciano C, Giuseppe P, Sabrina C, Susanna S, Antonio C, Giuseppe C, Giorgio de T, Claudio L - Int J Endocrinol (2012)

Bottom Line: Results.PHPT showed an important myocardial and vascular remodelling.During follow-up in PHPT patients, we found significant reduction of prevalence of metabolic syndrome, blood pressure, and "non-dipping phenomenon." Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Secondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome "Sapienza", Rome, Italy.

ABSTRACT
Background. Primary hyperparathyroidism (PHPT) is associated with high cardiovascular morbidity, and the role of calcium and parathyroid hormone is still controversial. Objective. To evaluate the prevalence and outcomes of metabolic syndrome, hypertension, and some cardiovascular alterations in asymptomatic PHPT, and specific changes after successful parathyroidectomy. Material and Methods. We examined 30 newly diagnosed PHPT patients (8 males, 22 females; mean age 56 ± 6 yrs), 30 patients with essential hypertension (EH) (9 males, 21 females; mean age 55 ± 4), and 30 normal subjects (NS) (9 males, 21 females: mean age 55 ± 6). All groups underwent evaluation with ambulatory monitoring blood pressure, echocardiography, and color-Doppler artery ultrasonography and were successively revaluated after one year from parathyroidectomy. Results. PHPT patients presented a higher prevalence of metabolic syndrome (38%) with respect to EH (28%). Prevalence of hypertension in PHPT was 81%, and 57% presented altered circadian rhythm of blood pressure, with respect to EH (35%) and NS (15%). PHPT showed an important myocardial and vascular remodelling. During follow-up in PHPT patients, we found significant reduction of prevalence of metabolic syndrome, blood pressure, and "non-dipping phenomenon." Conclusions. Cardiovascular and metabolic alterations should be considered as added parameters in evaluation of patients with asymptomatic PHPT.

No MeSH data available.


Related in: MedlinePlus

Linear correlation in PHPT patients between PTH levels and systolic blood pressure values (SBP) (r = 0.512, P < 0.05).
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fig2: Linear correlation in PHPT patients between PTH levels and systolic blood pressure values (SBP) (r = 0.512, P < 0.05).

Mentions: The ABPM showed significantly higher values of global-SBP (G-SBP), diurnal-SBP (D-SBP) and global DBP (G-DBP) in PHPT and EH patients compared to NS (Table 2). No significant difference were found for ABPM between PHPT and EH patients. At diagnosis, 57% of PHPT patients presented a nocturnal “non-dipping pattern” respect to 35% of EH patients and 15% of NS (Figure 1). Moreover, the correlation study revealed in PHPT patients, a positive correlation between SBP and PTH levels (r = 0.512; P < 0.05) (Figure 2) The prevalence of metabolic syndrome was present in 38% of PHPT and in 28% of EH patients (Figure 3).


Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results.

Luigi P, Chiara FM, Laura Z, Cristiano M, Giuseppina C, Luciano C, Giuseppe P, Sabrina C, Susanna S, Antonio C, Giuseppe C, Giorgio de T, Claudio L - Int J Endocrinol (2012)

Linear correlation in PHPT patients between PTH levels and systolic blood pressure values (SBP) (r = 0.512, P < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3375164&req=5

fig2: Linear correlation in PHPT patients between PTH levels and systolic blood pressure values (SBP) (r = 0.512, P < 0.05).
Mentions: The ABPM showed significantly higher values of global-SBP (G-SBP), diurnal-SBP (D-SBP) and global DBP (G-DBP) in PHPT and EH patients compared to NS (Table 2). No significant difference were found for ABPM between PHPT and EH patients. At diagnosis, 57% of PHPT patients presented a nocturnal “non-dipping pattern” respect to 35% of EH patients and 15% of NS (Figure 1). Moreover, the correlation study revealed in PHPT patients, a positive correlation between SBP and PTH levels (r = 0.512; P < 0.05) (Figure 2) The prevalence of metabolic syndrome was present in 38% of PHPT and in 28% of EH patients (Figure 3).

Bottom Line: Results.PHPT showed an important myocardial and vascular remodelling.During follow-up in PHPT patients, we found significant reduction of prevalence of metabolic syndrome, blood pressure, and "non-dipping phenomenon." Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Secondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome "Sapienza", Rome, Italy.

ABSTRACT
Background. Primary hyperparathyroidism (PHPT) is associated with high cardiovascular morbidity, and the role of calcium and parathyroid hormone is still controversial. Objective. To evaluate the prevalence and outcomes of metabolic syndrome, hypertension, and some cardiovascular alterations in asymptomatic PHPT, and specific changes after successful parathyroidectomy. Material and Methods. We examined 30 newly diagnosed PHPT patients (8 males, 22 females; mean age 56 ± 6 yrs), 30 patients with essential hypertension (EH) (9 males, 21 females; mean age 55 ± 4), and 30 normal subjects (NS) (9 males, 21 females: mean age 55 ± 6). All groups underwent evaluation with ambulatory monitoring blood pressure, echocardiography, and color-Doppler artery ultrasonography and were successively revaluated after one year from parathyroidectomy. Results. PHPT patients presented a higher prevalence of metabolic syndrome (38%) with respect to EH (28%). Prevalence of hypertension in PHPT was 81%, and 57% presented altered circadian rhythm of blood pressure, with respect to EH (35%) and NS (15%). PHPT showed an important myocardial and vascular remodelling. During follow-up in PHPT patients, we found significant reduction of prevalence of metabolic syndrome, blood pressure, and "non-dipping phenomenon." Conclusions. Cardiovascular and metabolic alterations should be considered as added parameters in evaluation of patients with asymptomatic PHPT.

No MeSH data available.


Related in: MedlinePlus