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Physicochemical properties and cellular responses of strontium-doped gypsum biomaterials.

Pouria A, Bandegani H, Pourbaghi-Masouleh M, Hesaraki S, Alizadeh M - Bioinorg Chem Appl (2012)

Bottom Line: Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens.Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration.These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one.

View Article: PubMed Central - PubMed

Affiliation: Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, P.O. Box 31787/316, Karaj 3177983634, Iran.

ABSTRACT
This paper describes some physical, structural, and biological properties of gypsum bioceramics doped with various amounts of strontium ions (0.19-2.23 wt%) and compares these properties with those of a pure gypsum as control. Strontium-doped gypsum (gypsum:Sr) was obtained by mixing calcium sulfate hemihydrate powder and solutions of strontium nitrate followed by washing the specimens with distilled water to remove residual salts. Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens. Microstructure of all gypsum specimens consisted of many rod-like small crystals entangled to each other with more elongation and higher thickness in the case of gypsum:Sr. The Sr-doped sample exhibited higher compressive strength and lower solubility than pure gypsum. A continuous release of strontium ions was observed from the gypsum:Sr during soaking it in simulated body fluid for 14 days. Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration. These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one.

No MeSH data available.


The powder density of gypsum specimens containing different contents of Sr dopant.
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Related In: Results  -  Collection


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fig7: The powder density of gypsum specimens containing different contents of Sr dopant.

Mentions: Figure 7 shows the effect of incorporation of Sr2+ ions into gypsum on its powder density. An increase in density of gypsum powder is observed by adding Sr in which the increase correlates with Sr concentration and the differences are statistically significant (P < 0.05). The increased powder density of Sr-doped gypsum in comparison with pure gypsum is due to the higher atomic weight of Sr (87.6 g/mol) compared to Ca (40.0 g/mol).


Physicochemical properties and cellular responses of strontium-doped gypsum biomaterials.

Pouria A, Bandegani H, Pourbaghi-Masouleh M, Hesaraki S, Alizadeh M - Bioinorg Chem Appl (2012)

The powder density of gypsum specimens containing different contents of Sr dopant.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3375162&req=5

fig7: The powder density of gypsum specimens containing different contents of Sr dopant.
Mentions: Figure 7 shows the effect of incorporation of Sr2+ ions into gypsum on its powder density. An increase in density of gypsum powder is observed by adding Sr in which the increase correlates with Sr concentration and the differences are statistically significant (P < 0.05). The increased powder density of Sr-doped gypsum in comparison with pure gypsum is due to the higher atomic weight of Sr (87.6 g/mol) compared to Ca (40.0 g/mol).

Bottom Line: Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens.Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration.These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one.

View Article: PubMed Central - PubMed

Affiliation: Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, P.O. Box 31787/316, Karaj 3177983634, Iran.

ABSTRACT
This paper describes some physical, structural, and biological properties of gypsum bioceramics doped with various amounts of strontium ions (0.19-2.23 wt%) and compares these properties with those of a pure gypsum as control. Strontium-doped gypsum (gypsum:Sr) was obtained by mixing calcium sulfate hemihydrate powder and solutions of strontium nitrate followed by washing the specimens with distilled water to remove residual salts. Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens. Microstructure of all gypsum specimens consisted of many rod-like small crystals entangled to each other with more elongation and higher thickness in the case of gypsum:Sr. The Sr-doped sample exhibited higher compressive strength and lower solubility than pure gypsum. A continuous release of strontium ions was observed from the gypsum:Sr during soaking it in simulated body fluid for 14 days. Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration. These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one.

No MeSH data available.