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Physicochemical properties and cellular responses of strontium-doped gypsum biomaterials.

Pouria A, Bandegani H, Pourbaghi-Masouleh M, Hesaraki S, Alizadeh M - Bioinorg Chem Appl (2012)

Bottom Line: Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens.Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration.These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one.

View Article: PubMed Central - PubMed

Affiliation: Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, P.O. Box 31787/316, Karaj 3177983634, Iran.

ABSTRACT
This paper describes some physical, structural, and biological properties of gypsum bioceramics doped with various amounts of strontium ions (0.19-2.23 wt%) and compares these properties with those of a pure gypsum as control. Strontium-doped gypsum (gypsum:Sr) was obtained by mixing calcium sulfate hemihydrate powder and solutions of strontium nitrate followed by washing the specimens with distilled water to remove residual salts. Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens. Microstructure of all gypsum specimens consisted of many rod-like small crystals entangled to each other with more elongation and higher thickness in the case of gypsum:Sr. The Sr-doped sample exhibited higher compressive strength and lower solubility than pure gypsum. A continuous release of strontium ions was observed from the gypsum:Sr during soaking it in simulated body fluid for 14 days. Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration. These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one.

No MeSH data available.


The SEM image of G-Sr4 specimen (a) along with its corresponding EDXA patterns (b).
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fig6: The SEM image of G-Sr4 specimen (a) along with its corresponding EDXA patterns (b).

Mentions: The SEM images of the specimens along with their corresponding EDXA patterns are illustrated in Figures 3to 6. Microstructure of pure gypsum (Figure 3(a)) was found to consists of many rod-like crystals entangled to each other and its corresponding EDXA pattern (Figure 3(b)) shows the presence of calcium and sulfur as main elements of gypsum as well as gold (Au) element created from the coating layer. Micrographs of Sr-doped gypsum specimens (Figure 4: G-Sr1, Figure 5: G-Sr2 and Figure 6: G-Sr4) show thicker rod-like crystals with more elongated and compacted morphologies compared to pure gypsum. In these images, the EDXA patterns taken from that crystal marked with an arrow reveal the presence of strontium dopant element in the composition of gypsum. Regarding uniform morphology of the crystals and lack of other phases in the gypsum:Sr (from XRD data), these EDXA patterns can be used as complementary proofs for incorporation of Sr ions into lattice structure of gypsum.


Physicochemical properties and cellular responses of strontium-doped gypsum biomaterials.

Pouria A, Bandegani H, Pourbaghi-Masouleh M, Hesaraki S, Alizadeh M - Bioinorg Chem Appl (2012)

The SEM image of G-Sr4 specimen (a) along with its corresponding EDXA patterns (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3375162&req=5

fig6: The SEM image of G-Sr4 specimen (a) along with its corresponding EDXA patterns (b).
Mentions: The SEM images of the specimens along with their corresponding EDXA patterns are illustrated in Figures 3to 6. Microstructure of pure gypsum (Figure 3(a)) was found to consists of many rod-like crystals entangled to each other and its corresponding EDXA pattern (Figure 3(b)) shows the presence of calcium and sulfur as main elements of gypsum as well as gold (Au) element created from the coating layer. Micrographs of Sr-doped gypsum specimens (Figure 4: G-Sr1, Figure 5: G-Sr2 and Figure 6: G-Sr4) show thicker rod-like crystals with more elongated and compacted morphologies compared to pure gypsum. In these images, the EDXA patterns taken from that crystal marked with an arrow reveal the presence of strontium dopant element in the composition of gypsum. Regarding uniform morphology of the crystals and lack of other phases in the gypsum:Sr (from XRD data), these EDXA patterns can be used as complementary proofs for incorporation of Sr ions into lattice structure of gypsum.

Bottom Line: Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens.Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration.These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one.

View Article: PubMed Central - PubMed

Affiliation: Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, P.O. Box 31787/316, Karaj 3177983634, Iran.

ABSTRACT
This paper describes some physical, structural, and biological properties of gypsum bioceramics doped with various amounts of strontium ions (0.19-2.23 wt%) and compares these properties with those of a pure gypsum as control. Strontium-doped gypsum (gypsum:Sr) was obtained by mixing calcium sulfate hemihydrate powder and solutions of strontium nitrate followed by washing the specimens with distilled water to remove residual salts. Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens. Microstructure of all gypsum specimens consisted of many rod-like small crystals entangled to each other with more elongation and higher thickness in the case of gypsum:Sr. The Sr-doped sample exhibited higher compressive strength and lower solubility than pure gypsum. A continuous release of strontium ions was observed from the gypsum:Sr during soaking it in simulated body fluid for 14 days. Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration. These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one.

No MeSH data available.