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Physicochemical properties and cellular responses of strontium-doped gypsum biomaterials.

Pouria A, Bandegani H, Pourbaghi-Masouleh M, Hesaraki S, Alizadeh M - Bioinorg Chem Appl (2012)

Bottom Line: Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens.Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration.These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one.

View Article: PubMed Central - PubMed

Affiliation: Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, P.O. Box 31787/316, Karaj 3177983634, Iran.

ABSTRACT
This paper describes some physical, structural, and biological properties of gypsum bioceramics doped with various amounts of strontium ions (0.19-2.23 wt%) and compares these properties with those of a pure gypsum as control. Strontium-doped gypsum (gypsum:Sr) was obtained by mixing calcium sulfate hemihydrate powder and solutions of strontium nitrate followed by washing the specimens with distilled water to remove residual salts. Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens. Microstructure of all gypsum specimens consisted of many rod-like small crystals entangled to each other with more elongation and higher thickness in the case of gypsum:Sr. The Sr-doped sample exhibited higher compressive strength and lower solubility than pure gypsum. A continuous release of strontium ions was observed from the gypsum:Sr during soaking it in simulated body fluid for 14 days. Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration. These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one.

No MeSH data available.


The FTIR spectra of pure gypsum (G-0) and Sr-doped gypsum (G-Sr4) in comparison with as-set G-Sr4 and G-Sr-4 specimen once after washing procedure.
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fig2: The FTIR spectra of pure gypsum (G-0) and Sr-doped gypsum (G-Sr4) in comparison with as-set G-Sr4 and G-Sr-4 specimen once after washing procedure.

Mentions: The FTIR spectra of pure gypsum and Sr-doped gypsum (G-Sr4) are shown in Figure 2. The spectrum of as-set G-Sr4 specimen (hardened specimen before washing with distilled water) and its spectrum once after washing with distilled water are also shown for comparison. The FTIR spectra show the stretching bands associated to the functional groups of the gypsum components, that is, H2O and SO42− groups labeled in the corresponding Figures. The FTIR spectra of all other Sr-doped gypsum specimens were closely similar to that of G-Sr4 and thus have not been illustrated. Decreased intensity of nitrate band once after washing and disappearance of this band after completion of the washing procedure confirms removal of the residual additive. As it is observed, the spectrum of gypsum:Sr is similar to the spectrum of pure gypsum and no extra bands are found.


Physicochemical properties and cellular responses of strontium-doped gypsum biomaterials.

Pouria A, Bandegani H, Pourbaghi-Masouleh M, Hesaraki S, Alizadeh M - Bioinorg Chem Appl (2012)

The FTIR spectra of pure gypsum (G-0) and Sr-doped gypsum (G-Sr4) in comparison with as-set G-Sr4 and G-Sr-4 specimen once after washing procedure.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3375162&req=5

fig2: The FTIR spectra of pure gypsum (G-0) and Sr-doped gypsum (G-Sr4) in comparison with as-set G-Sr4 and G-Sr-4 specimen once after washing procedure.
Mentions: The FTIR spectra of pure gypsum and Sr-doped gypsum (G-Sr4) are shown in Figure 2. The spectrum of as-set G-Sr4 specimen (hardened specimen before washing with distilled water) and its spectrum once after washing with distilled water are also shown for comparison. The FTIR spectra show the stretching bands associated to the functional groups of the gypsum components, that is, H2O and SO42− groups labeled in the corresponding Figures. The FTIR spectra of all other Sr-doped gypsum specimens were closely similar to that of G-Sr4 and thus have not been illustrated. Decreased intensity of nitrate band once after washing and disappearance of this band after completion of the washing procedure confirms removal of the residual additive. As it is observed, the spectrum of gypsum:Sr is similar to the spectrum of pure gypsum and no extra bands are found.

Bottom Line: Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens.Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration.These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one.

View Article: PubMed Central - PubMed

Affiliation: Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, P.O. Box 31787/316, Karaj 3177983634, Iran.

ABSTRACT
This paper describes some physical, structural, and biological properties of gypsum bioceramics doped with various amounts of strontium ions (0.19-2.23 wt%) and compares these properties with those of a pure gypsum as control. Strontium-doped gypsum (gypsum:Sr) was obtained by mixing calcium sulfate hemihydrate powder and solutions of strontium nitrate followed by washing the specimens with distilled water to remove residual salts. Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens. Microstructure of all gypsum specimens consisted of many rod-like small crystals entangled to each other with more elongation and higher thickness in the case of gypsum:Sr. The Sr-doped sample exhibited higher compressive strength and lower solubility than pure gypsum. A continuous release of strontium ions was observed from the gypsum:Sr during soaking it in simulated body fluid for 14 days. Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration. These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one.

No MeSH data available.