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Distribution, size, and shape of abdominal aortic calcified deposits and their relationship to mortality in postmenopausal women.

Ganz M, de Bruijne M, Dam EB, Pettersen P, Karsdal MA, Christiansen C, Nielsen M - Int J Biomed Imaging (2012)

Bottom Line: Methods.Results.Morphometric markers of AAC quantified from radiographs may be a useful tool for screening and monitoring risk of CVD mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Computer Science, University of Copenhagen, 2100 Copenhagen, Denmark.

ABSTRACT
Abdominal aortic calcifications (AACs) correlate strongly with coronary artery calcifications and can be predictors of cardiovascular mortality. We investigated whether size, shape, and distribution of AACs are related to mortality and how such prognostic markers perform compared to the state-of-the-art AC24 marker introduced by Kauppila. Methods. For 308 postmenopausal women, we quantified the number of AAC and the percentage of the abdominal aorta that the lesions occupied in terms of their area, simulated plaque area, thickness, wall coverage, and length. We analysed inter-/intraobserver reproducibility and predictive ability of mortality after 8-9 years via Cox regression leading to hazard ratios (HRs). Results. The coefficient of variation was below 25% for all markers. The strongest individual predictors were the number of calcifications (HR = 2.4) and the simulated area percentage (HR = 2.96) of a calcified plaque, and, unlike AC24 (HR = 1.66), they allowed mortality prediction also after adjusting for traditional risk factors. In a combined Cox regression model, the strongest complementary predictors were the number of calcifications (HR = 2.76) and the area percentage (HR = -3.84). Conclusion. Morphometric markers of AAC quantified from radiographs may be a useful tool for screening and monitoring risk of CVD mortality.

No MeSH data available.


Related in: MedlinePlus

An X-ray of a participant in the EPI followup population. (a): an annotation by a radiologist. (b): a second annotation by the same radiologist. (c): an annotation done by another radiologist.
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fig5: An X-ray of a participant in the EPI followup population. (a): an annotation by a radiologist. (b): a second annotation by the same radiologist. (c): an annotation done by another radiologist.

Mentions: On the set of 8 images with four annotations each, the mean Jaccard Index between the radiologists' AAC outlines was 0.56 ± 0.14 (0.24–0.79) for the intraobserver variation and 0.51 ± 0.13 (0.29–0.73) for the interobserver variation, for an example, see Figure 5. The two radiologists had an intraobserver variability of 0.53 ± 0.14 (0.24–0.65) and 0.59 ± 0.14 (0.38–0.79), respectively. The CV values for the AAC marker precision on the same set of 8 images were between 12.5% and 24.9% (Table 2).


Distribution, size, and shape of abdominal aortic calcified deposits and their relationship to mortality in postmenopausal women.

Ganz M, de Bruijne M, Dam EB, Pettersen P, Karsdal MA, Christiansen C, Nielsen M - Int J Biomed Imaging (2012)

An X-ray of a participant in the EPI followup population. (a): an annotation by a radiologist. (b): a second annotation by the same radiologist. (c): an annotation done by another radiologist.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3375152&req=5

fig5: An X-ray of a participant in the EPI followup population. (a): an annotation by a radiologist. (b): a second annotation by the same radiologist. (c): an annotation done by another radiologist.
Mentions: On the set of 8 images with four annotations each, the mean Jaccard Index between the radiologists' AAC outlines was 0.56 ± 0.14 (0.24–0.79) for the intraobserver variation and 0.51 ± 0.13 (0.29–0.73) for the interobserver variation, for an example, see Figure 5. The two radiologists had an intraobserver variability of 0.53 ± 0.14 (0.24–0.65) and 0.59 ± 0.14 (0.38–0.79), respectively. The CV values for the AAC marker precision on the same set of 8 images were between 12.5% and 24.9% (Table 2).

Bottom Line: Methods.Results.Morphometric markers of AAC quantified from radiographs may be a useful tool for screening and monitoring risk of CVD mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Computer Science, University of Copenhagen, 2100 Copenhagen, Denmark.

ABSTRACT
Abdominal aortic calcifications (AACs) correlate strongly with coronary artery calcifications and can be predictors of cardiovascular mortality. We investigated whether size, shape, and distribution of AACs are related to mortality and how such prognostic markers perform compared to the state-of-the-art AC24 marker introduced by Kauppila. Methods. For 308 postmenopausal women, we quantified the number of AAC and the percentage of the abdominal aorta that the lesions occupied in terms of their area, simulated plaque area, thickness, wall coverage, and length. We analysed inter-/intraobserver reproducibility and predictive ability of mortality after 8-9 years via Cox regression leading to hazard ratios (HRs). Results. The coefficient of variation was below 25% for all markers. The strongest individual predictors were the number of calcifications (HR = 2.4) and the simulated area percentage (HR = 2.96) of a calcified plaque, and, unlike AC24 (HR = 1.66), they allowed mortality prediction also after adjusting for traditional risk factors. In a combined Cox regression model, the strongest complementary predictors were the number of calcifications (HR = 2.76) and the area percentage (HR = -3.84). Conclusion. Morphometric markers of AAC quantified from radiographs may be a useful tool for screening and monitoring risk of CVD mortality.

No MeSH data available.


Related in: MedlinePlus